Tan Lab | DSigDB

Gene Set: D4 : TTD - ZAPRINAST

Collection

D4 : TTD

Chemical Name

ZAPRINAST ( From PubChem : ZAPRINAST )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
271.275 g/mol	2	5	1.497	True

Structure

InChI

InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)

InChIKey

Links

Gene (13 / 30)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			PDE1A		Successful target
TTD	Inhibitor			PDE1B		Successful target
TTD	Inhibitor			PDE1C		Successful target
TTD	Inhibitor			PDE4D		Successful target
TTD	Inhibitor			PDE5A		Successful target
PubChem	Potency	uM	19.953	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	22.387	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	15.849	ALOX15	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	14.125	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	5.012	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	6.310	HPGD	-	GI(Protien) :
PubChem	Potency	uM	8.912	HPGD	-	GI(Protien) :
PubChem	Potency	uM	15.849	HPGD	-	GI(Protien) :
PubChem	Potency	uM	1.585	USP2	-	GI(Protien) :
PubChem	Potency	uM	10.000	USP2	-	GI(Protien) :
ChEMBL	Potency	nM	19952.600	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	22387.200	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	15848.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	AC50	nM	3981.070	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	5011.870	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	14125.400	EHMT2	-	Target : CHEMBL6032
ChEMBL	Activity	-		GPR35	-	Target : CHEMBL1293267
ChEMBL	Potency	nM	5011.900	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	15848.900	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	8912.500	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	6309.600	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	10000.000	USP2	-	Target : CHEMBL1293227
ChEMBL	Potency	nM	1584.900	USP2	-	Target : CHEMBL1293227

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