DSigDB Collections
DSigDB organized drugs and small molecules related gene sets into four collections based on quantitative inhibition and/or drug-induced gene expression changes data. |
Collection | Description |
Unique Number of Genes |
Number of Gene Sets |
Download |
DSigDB | All Gene Sets. | 19,531 | 22,527 | GMT File |
D1 : FDA Approved ( browse 1,202 gene sets ) |
FDA Approved Drug Gene Sets. | 1,288 | 1,202 | GMT File |
D2 : Kinase Inhibitors |
Kinase Inhibitors Gene Sets based on in vitro kinase profiling assays. | 407 | 1,220 | GMT File |
FDA |
FDA Approved Kinase Inhibitors. | 341 | 28 | GMT File |
HMS LINCS |
Kinase inhibition assays extracted from HMS LINCS database. | 381 | 90 | GMT File |
MRC |
Kinase inhibition assays extracted from MRC Kinome Inhibition database. | 137 | 157 | GMT File |
GSK |
GSK Published Kinase Inhibitor Set (PKIS), kinase inhibitors used as chemical probes. | 116 | 204 | GMT File |
Roche |
Kinase Inhibitors profiled by Roche. | 153 | 570 | GMT File |
RBC |
Kinase Inhibitors profiled by Reaction Biology Corporation. | 246 | 99 | GMT File |
KinomeScan |
Kinase Inhibitors profiled by DiscoveryRx using KinomeScan technology. | 374 | 72 | GMT File |
D3 : Perturbagen Signatures ( browse 1,998 gene sets ) |
7,064 gene expression profiles from three cancer cell lines perturbed by 1,309 compounds from CMap (build 02). | 11,137 | 1,998 | GMT File |
CMAP |
7,064 gene expression profiles from three cancer cell lines perturbed by 1,309 compounds from CMap (build 02). | 11,137 | 1,998 | GMT File |
D4 : Computational Drug Signatures | Drug signatures extracted from literatures using a mixture of manual curation and by automatic computational approaches. | 18,854 | 18,107 | GMT File |
BOSS |
Text mining approach of drug-gene targets using Biomedical Object Search System (BOSS). | 3,354 | 2,114 | GMT File |
CTD |
Curation of targets from Comparative Toxicogenomics Database (CTD). | 18,700 | 5,163 | GMT File |
TTD |
Manual curation of targets from the Therapeutics Targets Database (TTD). | 1,389 | 10,830 | GMT File |