Tan Lab | DSigDB

Gene Set: D4 : TTD - Tozasertib

Collection

D4 : TTD

Chemical Name

Tozasertib ( From PubChem : TOZASERTIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
464.586 g/mol	3	8	3.6521	True

Structure

InChI

InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)

InChIKey

GCIKSSRWRFVXBI-UHFFFAOYSA-N

Links

Gene (22 / 43)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Multitarget			AURKA		Clinical trial target
TTD	Inhibitor			AURKA		Clinical trial target
TTD	Drug(s)			AURKA		Clinical trial target
TTD	Multitarget			AURKB		Clinical trial target
TTD	Inhibitor			AURKB		Clinical trial target
TTD	Drug(s)			AURKB		Clinical trial target
TTD	Multitarget			LCK		Successful target
TTD	Inhibitor			LCK		Successful target
TTD	Drug(s)			LCK		Successful target
PubChem	None	uM	6.300	ABL1	-	GI(Protien) :
PubChem	None	uM	9.100	ABL1	-	GI(Protien) :
PubChem	None	uM	9.400	ABL1	-	GI(Protien) :
PubChem	None	uM	4.000	ABL2	-	GI(Protien) :
PubChem	None	uM	4.100	AURKA	-	GI(Protien) :
PubChem	None	uM	7.400	AURKB	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	None	uM	4.300	FLT3	-	GI(Protien) :
PubChem	None	uM	6.500	FLT3	-	GI(Protien) :
PubChem	Potency	uM	0.259	GMNN	-	GI(Protien) :
PubChem	None	uM		KCNH2	-	GI(Protien) :
PubChem	None	uM		KCNQ1	-	GI(Protien) :
PubChem	None	uM		KCNQ1	-	GI(Protien) :
PubChem	None	uM		KCNQ1	-	GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MRGPRX1	-	GI(Protien) :
PubChem	None	uM		MRGPRX1	-	GI(Protien) :
PubChem	Potency	uM	0.097	YES1		GI(Protien) :
PubChem	Potency	uM	0.487	YES1		GI(Protien) :
ChEMBL	Activity	-		ABL2	-	Target : CHEMBL4014
ChEMBL	Activity	-		AURKA	-	Target : CHEMBL4722
ChEMBL	Activity	-		AURKB	-	Target : CHEMBL2185
ChEMBL	Activity	-		AURKB	-	Target : CHEMBL2185
ChEMBL	Activity	-		CSNK2A1	-	Target : CHEMBL3629
ChEMBL	Activity	-		MAP4K5	-	Target : CHEMBL4852
ChEMBL	Activity	-		MYLK	-	Target : CHEMBL2428
ChEMBL	Activity	-		PLK4	-	Target : CHEMBL3788
ChEMBL	Activity	-		RET	-	Target : CHEMBL2041
ChEMBL	Activity	-		STK11	-	Target : CHEMBL5606
ChEMBL	Activity	-		TNK1	-	Target : CHEMBL5334

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