Tan Lab | DSigDB

Gene Set: D4 : TTD - Pimozide

Collection

D4 : TTD

Chemical Name

Pimozide ( From PubChem : PIMOZIDE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
461.546 g/mol	1	3	5.7949	False(3/4)

Structure

InChI

InChI=1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)

InChIKey

YVUQSNJEYSNKRX-UHFFFAOYSA-N

Links

Gene (40 / 74)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Antagonist			DRD2		Successful target
TTD	Drug(s)			DRD2		Successful target
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	None	uM		ADRB2	-	GI(Protien) :
PubChem	None	uM		APAF1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	13.801	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	23.420	AR	-	GI(Protien) :
PubChem	Potency	uM	11.577	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	31.623	ATXN2	-	GI(Protien) :
PubChem	None	uM		CACNA1H	-	GI(Protien) :
PubChem	Potency	uM	35.481	CBX1	-	GI(Protien) :
PubChem	None	uM		CHRM1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	30.638	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	5.012	CYP3A4	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	2.512	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	5.012	HIF1A	-	GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	Potency	uM	16.360	IDH1	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	0.056	KCNH2		GI(Protien) :
PubChem	Potency	uM	0.056	KCNH2		GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	Potency	uM	25.119	MAPK1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	EC50	uM		MMP14	-	GI(Protien) :
PubChem	Potency	uM	22.387	MPHOSPH8	-	GI(Protien) :
PubChem	Potency	uM	16.482	MTOR	-	GI(Protien) :
PubChem	Potency	uM	6.310	NPSR1	-	GI(Protien) :
PubChem	Potency	uM	12.589	NPSR1	-	GI(Protien) :
PubChem	None	uM		NTSR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	33.489	PPARD	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	34.665	PPARG	-	GI(Protien) :
PubChem	Potency	uM	17.783	RXRA	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	6.684	TDP1	-	GI(Protien) :
PubChem	Potency	uM	14.581	TDP1	-	GI(Protien) :
PubChem	Potency	uM	25.479	TDP1	-	GI(Protien) :
PubChem	Potency	uM	32.076	TDP1	-	GI(Protien) :
PubChem	Potency	uM	10.000	THPO	-	GI(Protien) :
PubChem	Potency	uM	15.849	TP53	-	GI(Protien) :
PubChem	Potency	uM	25.119	TP53	-	GI(Protien) :
PubChem	Absolute IC50 (XBP1)	uM	10.000	XBP1	-	GI(Protien) :
ChEMBL	Potency	nM	11577.400	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	35481.300	CBX1	-	Target : CHEMBL1741193
ChEMBL	Potency	nM	10000.000	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	3162.280	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3162.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	10000.000	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3162.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	5011.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	5011.900	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	2511.900	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	39810.700	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	25118.900	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	22387.200	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	16481.600	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	12589.300	NPSR1	-	Target : CHEMBL5162
ChEMBL	Potency	nM	6309.600	NPSR1	-	Target : CHEMBL5162
ChEMBL	Potency	nM	10000.000	THPO	-	Target : CHEMBL1293256
ChEMBL	Potency	nM	15848.900	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	25118.900	TP53	-	Target : CHEMBL4096
ChEMBL	IC50	nM	10000.000	XBP1	-	Target : CHEMBL1741176

Download gene sets

gmt, text, Detailed text