Tan Lab | DSigDB

Gene Set: D4 : TTD - PD-98059

Collection

D4 : TTD

Chemical Name

PD-98059 ( From PubChem : PD 98059 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
267.279 g/mol	1	4	3.632	True

Structure

InChI

InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3

InChIKey

QFWCYNPOPKQOKV-UHFFFAOYSA-N

Links

Gene (36 / 73)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			AKT1		Clinical trial target
TTD	Inhibitor			AKT2		Clinical trial target
TTD	Inhibitor			AKT3		Clinical trial target
TTD	Inhibitor			CHEK1		Clinical trial target
TTD	Inhibitor			GSK3B		Clinical trial target
TTD	Inhibitor			LCK		Successful target
TTD	Inhibitor			MAP2K1		Successful target
TTD	Inhibitor			MAP3K1		Research target
TTD	Inhibitor			MAP3K2		Research target
TTD	Inhibitor			MAPK1		Research target
TTD	Inhibitor			MAPK11		Research target
TTD	Inhibitor			MAPK12		Clinical trial target
TTD	Inhibitor			MAPK14		Clinical trial target
TTD	Inhibitor			MAPK8		Clinical trial target
TTD	Inhibitor			PRKCA		Clinical trial target
TTD	Inhibitor			RAF1		Clinical trial target
TTD	Inhibitor			ROCK1		Clinical trial target
TTD	Inhibitor			RPS6KB1		Discontinued target
TTD	Inhibitor			SGK1		Research target
PubChem	Potency	uM	2.908	ATAD5	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	31.623	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	6.310	HPGD	-	GI(Protien) :
PubChem	Potency	uM	12.589	HPGD	-	GI(Protien) :
PubChem	Potency	uM	3.162	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	3.981	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	5.012	MAPK1	-	GI(Protien) :
PubChem	Potency	uM	15.849	MAPT	-	GI(Protien) :
PubChem	Potency	uM	2.311	NPC1	-	GI(Protien) :
PubChem	Potency	uM	15.849	PKM	-	GI(Protien) :
PubChem	Potency	uM	2.060	RAB9A	-	GI(Protien) :
PubChem	Potency	uM	7.943	SMN2	-	GI(Protien) :
PubChem	Potency	uM	8.912	SMN2	-	GI(Protien) :
PubChem	Potency	uM	11.220	SMN2	-	GI(Protien) :
PubChem	Potency	uM	29.855	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.398	THPO	-	GI(Protien) :
PubChem	Potency	uM	5.012	TP53	-	GI(Protien) :
PubChem	Potency	uM	7.943	TP53	-	GI(Protien) :
ChEMBL	Potency	nM	2908.100	ATAD5	-	Target : CHEMBL1741209
ChEMBL	AC50	nM	199.530	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	6309.570	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	6309.600	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	31622.800	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	31622.800	CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	7943.280	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	7943.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	7943.280	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	7943.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	12589.300	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	6309.600	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	3981.100	MAPK1	-	Target : CHEMBL4040
ChEMBL	Inhibition	-		MAPK1	-	Target : CHEMBL1907606
ChEMBL	Potency	nM	3162.300	MAPK1	-	Target : CHEMBL4040
ChEMBL	Potency	nM	5011.900	MAPK1	-	Target : CHEMBL4040
ChEMBL	Inhibition	-		MAPK3	-	Target : CHEMBL1907606
ChEMBL	Potency	nM	15848.900	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	2310.900	NPC1	-	Target : CHEMBL1293277
ChEMBL	Potency	nM	15848.900	PKM	-	Target : CHEMBL1075189
ChEMBL	Potency	nM	2059.600	RAB9A	-	Target : CHEMBL1293294
ChEMBL	Potency	nM	7943.300	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	8912.500	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	11220.200	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Potency	nM	398.100	THPO	-	Target : CHEMBL1293256
ChEMBL	Potency	nM	5011.900	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	7943.300	TP53	-	Target : CHEMBL4096

Download gene sets

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