Tan Lab | DSigDB

Gene Set: D4 : CTD - Sertraline

Collection

D4 : CTD

Chemical Name

Sertraline ( From PubChem : SERTRALINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
306.23 g/mol	1	1	5.5705	False(3/4)

Structure

InChI

InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1

InChIKey

VGKDLMBJGBXTGI-SJCJKPOMSA-N

Links

Gene (109 / 156)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(activity)			ABCB1		D020280
CTD	increases(expression)			ASAH1		D020280
CTD	increases(expression)			ASNS		D020280
CTD	increases(expression)			ATF2		D020280
CTD	increases(expression)			ATF4		D020280
CTD	decreases(expression)			BCL2		D020280
CTD	increases(expression)			C10ORF10		D020280
CTD	decreases(reaction)			CASP3		D020280
CTD	increases(activity)			CASP3		D020280
CTD	increases(activity)			CASP3		D020280
CTD	increases(cleavage)			CASP3		D020280
CTD	decreases(reaction)			CASP4		D020280
CTD	increases(cleavage)			CASP4		D020280
CTD	decreases(reaction)			CASP7		D020280
CTD	increases(activity)			CASP7		D020280
CTD	increases(activity)			CASP9		D020280
CTD	increases(cleavage)			CASP9		D020280
CTD	decreases(expression)			CD14		D020280
CTD	increases(expression)			CRYAA		D020280
CTD	decreases(expression)			CUL1		D020280
CTD	decreases(methylation)			CYP2B6		D020280
CTD	increases(metabolic processing)			CYP2B6		D020280
CTD	affects(metabolic processing)			CYP2C19		D020280
CTD	decreases(amination)			CYP2C19		D020280
CTD	increases(metabolic processing)			CYP2C19		D020280
CTD	decreases(methylation)			CYP2C19		D020280
CTD	decreases(methylation)			CYP2C19		D020280
CTD	increases(metabolic processing)			CYP2C19		D020280
CTD	decreases(methylation)			CYP2C9		D020280
CTD	increases(metabolic processing)			CYP2C9		D020280
CTD	affects(metabolic processing)			CYP2C9		D020280
CTD	decreases(reaction)			CYP2C9		D020280
CTD	decreases(methylation)			CYP2D6		D020280
CTD	increases(metabolic processing)			CYP2D6		D020280
CTD	decreases(amination)			CYP3A4		D020280
CTD	increases(metabolic processing)			CYP3A4		D020280
CTD	decreases(methylation)			CYP3A4		D020280
CTD	increases(oxidation)			CYP3A4		D020280
CTD	increases(reaction)			CYP3A4		D020280
CTD	decreases(reaction)			DDIT3		D020280
CTD	increases(expression)			DDIT3		D020280
CTD	increases(expression)			DNAJC5		D020280
CTD	increases(expression)			DUSP1		D020280
CTD	increases(expression)			DUSP10		D020280
CTD	increases(expression)			DUSP14		D020280
CTD	increases(expression)			DUSP16		D020280
CTD	increases(expression)			DUSP8		D020280
CTD	increases(expression)			EGFR		D020280
CTD	decreases(reaction)			EIF2AK3		D020280
CTD	increases(phosphorylation)			EIF2AK3		D020280
CTD	increases(expression)			EIF2AK3		D020280
CTD	increases(phosphorylation)			EIF2S1		D020280
CTD	increases(expression)			ERN1		D020280
CTD	increases(expression)			FABP1		D020280
CTD	increases(expression)			FNDC4		D020280
CTD	increases(expression)			FOS		D020280
CTD	increases(expression)			GADD45A		D020280
CTD	increases(expression)			GADD45B		D020280
CTD	increases(expression)			GDPD3		D020280
CTD	increases(expression)			HERPUD1		D020280
CTD	increases(expression)			HPN		D020280
CTD	increases(expression)			HSPA1A		D020280
CTD	increases(expression)			HSPA1B		D020280
CTD	increases(expression)			HSPA6		D020280
CTD	decreases(expression)			HSPA8		D020280
CTD	increases(expression)			INHBE		D020280
CTD	increases(expression)			JUN		D020280
CTD	increases(phosphorylation)			JUN		D020280
CTD	increases(expression)			JUN		D020280
CTD	increases(expression)			JUND		D020280
CTD	increases(expression)			LSS		D020280
CTD	decreases(amination)			MAOA		D020280
CTD	increases(metabolic processing)			MAOA		D020280
CTD	decreases(amination)			MAOB		D020280
CTD	increases(metabolic processing)			MAOB		D020280
CTD	increases(expression)			MAP3K13		D020280
CTD	increases(expression)			MAP3K8		D020280
CTD	decreases(reaction)			MAP4K4		D020280
CTD	increases(cleavage)			MAP4K4		D020280
CTD	increases(expression)			MAP4K4		D020280
CTD	increases(phosphorylation)			MAP4K4		D020280
CTD	decreases(expression)			MAP4K4		D020280
CTD	decreases(reaction)			MAPK1		D020280
CTD	increases(phosphorylation)			MAPK1		D020280
CTD	increases(phosphorylation)			MAPK3		D020280
CTD	increases(expression)			MAPK8IP3		D020280
CTD	decreases(expression)			MCL1		D020280
CTD	increases(expression)			MYC		D020280
CTD	increases(expression)			NFE2L2		D020280
CTD	increases(expression)			NFKB1		D020280
CTD	increases(expression)			NFKB2		D020280
CTD	increases(expression)			NR0B2		D020280
CTD	increases(expression)			NUPR1		D020280
CTD	decreases(expression)			PECAM1		D020280
CTD	decreases(expression)			PF4		D020280
CTD	increases(expression)			PHYH		D020280
CTD	decreases(expression)			PPBP		D020280
CTD	increases(expression)			PPP1R15A		D020280
CTD	decreases(expression)			PTGS2		D020280
CTD	decreases(expression)			RBX1		D020280
CTD	increases(expression)			RELB		D020280
CTD	decreases(expression)			RPS6KA3		D020280
CTD	decreases(expression)			SEC61G		D020280
CTD	decreases(expression)			SELE		D020280
CTD	decreases(expression)			SELP		D020280
CTD	increases(expression)			SERPINA3		D020280
CTD	decreases(expression)			SKP1		D020280
CTD	decreases(expression)			SLC2A3		D020280
CTD	decreases(reaction)			SLC6A4		D020280
CTD	increases(expression)			SLC6A4		D020280
CTD	increases(response to substance)			SLC6A4		D020280
CTD	affects(response to substance)			SLC6A4		D020280
CTD	increases(expression)			SSR2		D020280
CTD	decreases(expression)			STAT3		D020280
CTD	decreases(expression)			STMN1		D020280
CTD	increases(expression)			SYVN1		D020280
CTD	decreases(expression)			TAGLN		D020280
CTD	increases(expression)			TAOK2		D020280
CTD	decreases(secretion)			TNF		D020280
CTD	increases(expression)			TNF		D020280
CTD	decreases(expression)			TXNDC5		D020280
CTD	decreases(expression)			UBE2D4		D020280
CTD	decreases(expression)			UBE2G1		D020280
CTD	decreases(expression)			UBE4B		D020280
CTD	increases(expression)			UBQLN1		D020280
CTD	increases(glucuronidation)			UGT2B7		D020280
CTD	increases(metabolic processing)			UGT2B7		D020280
CTD	increases(expression)			VCAM1		D020280
CTD	increases(expression)			VIMP		D020280
CTD	increases(expression)			WIPI1		D020280
CTD	increases(splicing)			XBP1		D020280
PubChem	None	uM		APAF1	-	GI(Protien) :
PubChem	Potency	uM	14.125	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	25.119	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	10.000	DRD1	-	GI(Protien) :
PubChem	Potency	uM	11.220	DRD1	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	Potency	uM	10.322	IDH1	-	GI(Protien) :
PubChem	None	uM		MCHR1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		NPBWR1	-	GI(Protien) :
PubChem	None	uM		NPBWR1	-	GI(Protien) :
PubChem	None	uM		SLC5A7	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		TAAR1	-	GI(Protien) :
PubChem	None	uM		UBE2N	-	GI(Protien) :
ChEMBL	Activity	-		CDK1	-	Target : CHEMBL308
ChEMBL	Activity	-		CDK1	-	Target : CHEMBL308
ChEMBL	Inhibition	-		CFL1	-	Target : CHEMBL1075129
ChEMBL	Activity	-		CFL1	-	Target : CHEMBL1075129
ChEMBL	Potency	nM	11220.200	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	10000.000	DRD1	-	Target : CHEMBL2056
ChEMBL	Activity	-		JUN	-	Target : CHEMBL4977
ChEMBL	Activity	-		TP53	-	Target : CHEMBL4096

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