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Gene Set: D4 : CTD - Topotecan

Collection D4 : CTD
Chemical Name Topotecan ( From PubChem : TOPOTECAN )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
ApprovedNotNotNotNotNotNotNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
421.446 g/mol 2 8 1.8468 True
Structure
InChI InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1
InChIKey UCFGDBYHRUNTLO-QHCPKHFHSA-N
Links

Gene (250 / 311)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
CTDdecreases(activity)ABCB1
D019772
CTDdecreases(export)ABCB1
D019772
CTDincreases(expression)ABCB1
D019772
CTDdecreases(activity)ABCC2
D019772
CTDdecreases(export)ABCC2
D019772
CTDincreases(expression)ABCC2
D019772
CTDaffects(response to substance)ABCD3
D019772
CTDaffects(export)ABCG2
D019772
CTDaffects(transport)ABCG2
D019772
CTDdecreases(response to substance)ABCG2
D019772
CTDincreases(export)ABCG2
D019772
CTDincreases(response to substance)ABCG2
D019772
CTDincreases(transport)ABCG2
D019772
CTDdecreases(activity)ABCG2
D019772
CTDdecreases(export)ABCG2
D019772
CTDincreases(reaction)ABCG2
D019772
CTDincreases(expression)ABCG2
D019772
CTDaffects(response to substance)ACAT2
D019772
CTDaffects(response to substance)ACSL3
D019772
CTDaffects(response to substance)ACTG2
D019772
CTDaffects(response to substance)ADAMTS1
D019772
CTDaffects(response to substance)ADD3
D019772
CTDaffects(response to substance)AIM1
D019772
CTDaffects(response to substance)AKT3
D019772
CTDaffects(response to substance)ALAD
D019772
CTDaffects(response to substance)ANKRD10
D019772
CTDaffects(response to substance)ANP32A
D019772
CTDaffects(response to substance)AOX1
D019772
CTDaffects(response to substance)AP5M1
D019772
CTDaffects(response to substance)APOBEC3C
D019772
CTDaffects(response to substance)ARGLU1
D019772
CTDaffects(response to substance)ASS1
D019772
CTDaffects(response to substance)AUTS2
D019772
CTDaffects(response to substance)BCKDHA
D019772
CTDdecreases(expression)BCL2
D019772
CTDdecreases(expression)BCL2L12
D019772
CTDaffects(response to substance)BID
D019772
CTDaffects(response to substance)BIRC2
D019772
CTDaffects(cotreatment)BIRC5
D019772
CTDdecreases(reaction)BIRC5
D019772
CTDincreases(degradation)BIRC5
D019772
CTDaffects(response to substance)BOP1
D019772
CTDaffects(response to substance)BORA
D019772
CTDaffects(response to substance)C11ORF49
D019772
CTDaffects(response to substance)CABYR
D019772
CTDaffects(response to substance)CAMK1
D019772
CTDaffects(response to substance)CAMSAP2
D019772
CTDdecreases(reaction)CASP2
D019772
CTDincreases(cleavage)CASP2
D019772
CTDincreases(reaction)CASP2
D019772
CTDaffects(cotreatment)CASP3
D019772
CTDincreases(activity)CASP3
D019772
CTDdecreases(reaction)CASP3
D019772
CTDincreases(activity)CASP3
D019772
CTDincreases(activity)CASP3
D019772
CTDdecreases(reaction)CASP3
D019772
CTDincreases(activity)CASP3
D019772
CTDaffects(response to substance)CASP6
D019772
CTDaffects(cotreatment)CASP7
D019772
CTDincreases(activity)CASP7
D019772
CTDaffects(cotreatment)CASP8
D019772
CTDincreases(activity)CASP8
D019772
CTDdecreases(reaction)CASP8
D019772
CTDincreases(activity)CASP8
D019772
CTDaffects(response to substance)CAT
D019772
CTDincreases(expression)CAT
D019772
CTDaffects(response to substance)CCNB2
D019772
CTDdecreases(expression)CCNE1
D019772
CTDaffects(response to substance)CCNF
D019772
CTDaffects(response to substance)CCNG2
D019772
CTDaffects(response to substance)CD24
D019772
CTDaffects(response to substance)CDH1
D019772
CTDaffects(response to substance)CDKN1C
D019772
CTDaffects(response to substance)CENPU
D019772
CTDaffects(response to substance)CITED2
D019772
CTDaffects(response to substance)CKAP2
D019772
CTDaffects(response to substance)CLCN3
D019772
CTDaffects(response to substance)COL6A1
D019772
CTDaffects(response to substance)COL6A2
D019772
CTDaffects(response to substance)COX17
D019772
CTDaffects(response to substance)CSF2RA
D019772
CTDaffects(response to substance)CSTF2T
D019772
CTDdecreases(reaction)CTNNB1
D019772
CTDincreases(cleavage)CTNNB1
D019772
CTDaffects(response to substance)CTSL
D019772
CTDaffects(response to substance)CUL4A
D019772
CTDaffects(response to substance)CYB5A
D019772
CTDaffects(response to substance)DDIT4
D019772
CTDaffects(response to substance)DKK3
D019772
CTDaffects(response to substance)DLC1
D019772
CTDaffects(response to substance)DRAP1
D019772
CTDaffects(response to substance)DSE
D019772
CTDaffects(response to substance)DSP
D019772
CTDaffects(response to substance)DUSP3
D019772
CTDaffects(response to substance)DZIP1
D019772
CTDdecreases(expression)EGFR
D019772
CTDdecreases(phosphorylation)EGFR
D019772
CTDdecreases(activity)EGFR
D019772
CTDdecreases(response to substance)EGFR
D019772
CTDaffects(response to substance)EIF5A
D019772
CTDaffects(response to substance)ELL3
D019772
CTDaffects(response to substance)ENOPH1
D019772
CTDaffects(response to substance)EPCAM
D019772
CTDaffects(response to substance)ERBB3
D019772
CTDaffects(response to substance)ESRP1
D019772
CTDaffects(response to substance)EVA1B
D019772
CTDaffects(response to substance)EZH2
D019772
CTDaffects(response to substance)FAM111A
D019772
CTDaffects(response to substance)FAM129A
D019772
CTDaffects(response to substance)FAM171A1
D019772
CTDaffects(response to substance)FANCI
D019772
CTDaffects(response to substance)FANCL
D019772
CTDdecreases(expression)FAS
D019772
CTDaffects(response to substance)FDFT1
D019772
CTDaffects(response to substance)FERMT2
D019772
CTDaffects(response to substance)FGD1
D019772
CTDaffects(response to substance)FGF2
D019772
CTDaffects(response to substance)FHL1
D019772
CTDaffects(response to substance)FIG4
D019772
CTDaffects(response to substance)FJX1
D019772
CTDaffects(response to substance)FLNC
D019772
CTDdecreases(reaction)FOS
D019772
CTDincreases(expression)FOS
D019772
CTDaffects(response to substance)FOXD1
D019772
CTDaffects(response to substance)FRMD4A
D019772
CTDaffects(response to substance)FTH1
D019772
CTDaffects(response to substance)FUCA1
D019772
CTDaffects(response to substance)GALNT1
D019772
CTDaffects(response to substance)GALNT3
D019772
CTDaffects(response to substance)GCA
D019772
CTDaffects(response to substance)GCH1
D019772
CTDaffects(response to substance)GJA1
D019772
CTDaffects(response to substance)GMDS
D019772
CTDaffects(response to substance)GPSM2
D019772
CTDaffects(response to substance)GSPT2
D019772
CTDaffects(response to substance)GTF2I
D019772
CTDaffects(response to substance)H2AFV
D019772
CTDaffects(cotreatment)H2AFX
D019772
CTDincreases(expression)H2AFX
D019772
CTDincreases(phosphorylation)H2AFX
D019772
CTDaffects(response to substance)HADH
D019772
CTDaffects(response to substance)HDAC9
D019772
CTDaffects(localization)HIF1A
D019772
CTDdecreases(reaction)HIF1A
D019772
CTDaffects(binding)HIF1A
D019772
CTDincreases(reaction)HIF1A
D019772
CTDdecreases(expression)HIF1A
D019772
CTDaffects(response to substance)HMGA1
D019772
CTDaffects(response to substance)HMGA2
D019772
CTDaffects(response to substance)HMGB1
D019772
CTDaffects(response to substance)HMGB2
D019772
CTDaffects(response to substance)HMGCS1
D019772
CTDaffects(response to substance)HMGN3
D019772
CTDaffects(response to substance)HN1L
D019772
CTDaffects(response to substance)HNRNPDL
D019772
CTDaffects(response to substance)HOXB2
D019772
CTDaffects(response to substance)HSPA2
D019772
CTDaffects(response to substance)HTATIP2
D019772
CTDaffects(response to substance)IGFBP3
D019772
CTDaffects(response to substance)IGFBP7
D019772
CTDaffects(response to substance)IL1RAPL1
D019772
CTDaffects(response to substance)INHBA
D019772
CTDaffects(response to substance)INSIG1
D019772
CTDaffects(response to substance)ISG15
D019772
CTDaffects(response to substance)ITGA5
D019772
CTDdecreases(reaction)JUN
D019772
CTDincreases(expression)JUN
D019772
CTDaffects(binding)JUN
D019772
CTDincreases(reaction)JUN
D019772
CTDincreases(phosphorylation)JUN
D019772
CTDaffects(response to substance)KCNMA1
D019772
CTDaffects(response to substance)KCTD3
D019772
CTDaffects(response to substance)KRT19
D019772
CTDaffects(response to substance)LAMC1
D019772
CTDaffects(response to substance)LARP6
D019772
CTDaffects(response to substance)LEPR
D019772
CTDaffects(response to substance)LIMK2
D019772
CTDaffects(response to substance)LIN7C
D019772
CTDaffects(response to substance)LOXL2
D019772
CTDaffects(response to substance)LTBP2
D019772
CTDaffects(response to substance)MACF1
D019772
CTDaffects(response to substance)MAGED1
D019772
CTDaffects(response to substance)MBD4
D019772
CTDaffects(response to substance)MBP
D019772
CTDaffects(response to substance)MCTP2
D019772
CTDaffects(response to substance)MEST
D019772
CTDdecreases(expression)MGMT
D019772
CTDaffects(response to substance)MKNK2
D019772
CTDaffects(response to substance)MMP1
D019772
CTDaffects(response to substance)MOK
D019772
CTDaffects(response to substance)MPZL2
D019772
CTDaffects(response to substance)MRPL57
D019772
CTDaffects(response to substance)MSMO1
D019772
CTDdecreases(reaction)MTOR
D019772
CTDincreases(phosphorylation)MTOR
D019772
CTDaffects(response to substance)MTUS1
D019772
CTDaffects(response to substance)MYO1D
D019772
CTDaffects(response to substance)NAB1
D019772
CTDaffects(response to substance)NCAPH
D019772
CTDaffects(response to substance)NMT2
D019772
CTDaffects(response to substance)NOC3L
D019772
CTDaffects(response to substance)NRIP3
D019772
CTDaffects(response to substance)NSMAF
D019772
CTDaffects(response to substance)NUDT4
D019772
CTDaffects(response to substance)OPTN
D019772
CTDdecreases(expression)PCNA
D019772
CTDaffects(response to substance)PDE8A
D019772
CTDaffects(response to substance)PDGFC
D019772
CTDaffects(response to substance)PIN4
D019772
CTDaffects(response to substance)PLOD2
D019772
CTDaffects(response to substance)PNMAL1
D019772
CTDaffects(response to substance)PTPRK
D019772
CTDaffects(response to substance)PTRF
D019772
CTDaffects(response to substance)PTX3
D019772
CTDaffects(response to substance)QKI
D019772
CTDaffects(response to substance)RAB13
D019772
CTDaffects(response to substance)RAB20
D019772
CTDaffects(response to substance)RAB29
D019772
CTDaffects(response to substance)RAI14
D019772
CTDaffects(response to substance)RANBP1
D019772
CTDaffects(response to substance)RDX
D019772
CTDaffects(response to substance)RFTN1
D019772
CTDaffects(response to substance)RGS20
D019772
CTDaffects(response to substance)RIPK2
D019772
CTDaffects(response to substance)RNF219
D019772
CTDaffects(response to substance)RPA1
D019772
CTDaffects(response to substance)SAP18
D019772
CTDaffects(response to substance)SAR1A
D019772
CTDaffects(response to substance)SATB1
D019772
CTDaffects(response to substance)SCD
D019772
CTDaffects(response to substance)SCRN1
D019772
CTDaffects(response to substance)SEC14L1
D019772
CTDaffects(response to substance)SERPINB1
D019772
CTDaffects(response to substance)SERPINB2
D019772
CTDaffects(response to substance)SERPINE1
D019772
CTDaffects(response to substance)SFRP1
D019772
CTDaffects(response to substance)SKP2
D019772
CTDaffects(response to substance)SLC35G2
D019772
CTDaffects(response to substance)SLC38A6
D019772
CTDaffects(response to substance)SLC39A8
D019772
CTDaffects(response to substance)SMARCA4
D019772
CTDaffects(response to substance)SNAPC1
D019772
CTDaffects(response to substance)SNRPA1
D019772
CTDaffects(response to substance)SORL1
D019772
CTDaffects(response to substance)SPAG9
D019772
CTDaffects(response to substance)SPP1
D019772
CTDaffects(response to substance)SRD5A1
D019772
CTDaffects(response to substance)SRGN
D019772
CTDaffects(response to substance)SRI
D019772
CTDaffects(response to substance)ST7
D019772
CTDaffects(response to substance)STC1
D019772
CTDaffects(response to substance)SUV420H1
D019772
CTDaffects(response to substance)TBC1D4
D019772
CTDaffects(response to substance)TCF3
D019772
CTDaffects(response to substance)TCF7L2
D019772
CTDaffects(response to substance)TFPI
D019772
CTDaffects(response to substance)TFPI2
D019772
CTDaffects(response to substance)TGM2
D019772
CTDaffects(response to substance)TIA1
D019772
CTDaffects(response to substance)TMC6
D019772
CTDaffects(response to substance)TMEM80
D019772
CTDaffects(response to substance)TMEM97
D019772
CTDaffects(response to substance)TNFAIP8
D019772
CTDaffects(response to substance)TNFRSF6B
D019772
CTDdecreases(expression)TOP2A
D019772
CTDincreases(activity)TP53
D019772
CTDincreases(expression)TP53
D019772
CTDdecreases(reaction)TP53
D019772
CTDincreases(activity)TP53
D019772
CTDincreases(cleavage)TP53
D019772
CTDaffects(response to substance)TPK1
D019772
CTDaffects(response to substance)TPM1
D019772
CTDdecreases(reaction)TREX1
D019772
CTDincreases(expression)TREX1
D019772
CTDaffects(binding)TREX1
D019772
CTDincreases(reaction)TREX1
D019772
CTDaffects(response to substance)TREX1
D019772
CTDaffects(response to substance)TRIM2
D019772
CTDaffects(response to substance)TRPC1
D019772
CTDaffects(response to substance)TSPAN13
D019772
CTDaffects(response to substance)TSPAN8
D019772
CTDaffects(response to substance)TST
D019772
CTDaffects(response to substance)TUBB6
D019772
CTDaffects(response to substance)TUBGCP3
D019772
CTDaffects(response to substance)TXNIP
D019772
CTDaffects(response to substance)UBA1
D019772
CTDaffects(response to substance)UBE2I
D019772
CTDaffects(response to substance)UCHL1
D019772
CTDaffects(response to substance)ULK2
D019772
CTDaffects(response to substance)UNG
D019772
CTDaffects(response to substance)URI1
D019772
CTDaffects(response to substance)VCAN
D019772
CTDaffects(binding)VEGFA
D019772
CTDdecreases(reaction)VEGFA
D019772
CTDincreases(reaction)VEGFA
D019772
CTDincreases(expression)VEGFA
D019772
CTDdecreases(expression)VEGFA
D019772
CTDaffects(response to substance)VIM
D019772
CTDaffects(response to substance)WEE1
D019772
CTDaffects(cotreatment)XIAP
D019772
CTDdecreases(reaction)XIAP
D019772
CTDincreases(degradation)XIAP
D019772
CTDaffects(response to substance)XIST
D019772
CTDaffects(response to substance)ZBED5
D019772
CTDaffects(response to substance)ZEB1
D019772
CTDaffects(response to substance)ZNF710
D019772
ChEMBLInhibition-AKT1
-Target : CHEMBL4282
ChEMBLInhibition-TOP1
-Target : CHEMBL1781
ChEMBLInhibition-TOP1
-Target : CHEMBL1781
ChEMBLInhibition-TOP1
-Target : CHEMBL1781
ChEMBLActivity-TOP1
-Target : CHEMBL1781
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Aurora, CO 80045, USA

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