Tan Lab | DSigDB

Gene Set: D4 : CTD - Guanfacine

Collection

D4 : CTD

Chemical Name

Guanfacine ( From PubChem : GUANFACINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Approved	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
246.093 g/mol	2	4	2.7365	True

Structure

InChI

InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)

InChIKey

Links

Gene (7 / 18)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			GH1		D016316
CTD	decreases(activity)			REN		D016316
CTD	decreases(reaction)			SLC22A2		D016316
CTD	increases(uptake)			SLC22A2		D016316
PubChem	Potency	uM	0.251	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	0.126	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	12.589	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	12.589	EHMT2	-	GI(Protien) :
ChEMBL	AC50	nM	251.190	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	251.200	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	125.890	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	125.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	12589.200	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	12589.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	12589.300	EHMT2	-	Target : CHEMBL6032

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