Tan Lab | DSigDB

Gene Set: D4 : CTD - Thiostrepton

Collection

D4 : CTD

Chemical Name

Thiostrepton ( From PubChem : THIOSTREPTON )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
1664.89 g/mol	17	42	4.0864	False(1/4)

Structure

InChI

InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15+

InChIKey

NSFFHOGKXHRQEW-DVRIZHICSA-N

Links

Gene (44 / 49)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			BAX		D013883
CTD	decreases(expression)			BCL2		D013883
CTD	decreases(expression)			BCL2L1		D013883
CTD	decreases(expression)			CCL3		D013883
CTD	decreases(expression)			CCL4		D013883
CTD	decreases(expression)			CCND1		D013883
CTD	increases(expression)			CDKN1A		D013883
CTD	increases(expression)			CRYAB		D013883
CTD	decreases(expression)			CYP1A1		D013883
CTD	decreases(expression)			CYP2E1		D013883
CTD	increases(expression)			DDIT3		D013883
CTD	increases(expression)			DNAJA1		D013883
CTD	increases(expression)			DNAJB4		D013883
CTD	increases(expression)			EIF2S1		D013883
CTD	increases(expression)			GADD45A		D013883
CTD	increases(expression)			GDF15		D013883
CTD	increases(expression)			GSR		D013883
CTD	decreases(reaction)			GSTP1		D013883
CTD	increases(metabolic processing)			GSTP1		D013883
CTD	increases(expression)			HMOX1		D013883
CTD	increases(expression)			HSP90AA2P		D013883
CTD	increases(expression)			HSP90AB1		D013883
CTD	increases(expression)			HSPA1A		D013883
CTD	increases(expression)			HSPA1L		D013883
CTD	increases(expression)			HSPA2		D013883
CTD	increases(expression)			HSPA4		D013883
CTD	increases(expression)			HSPA5		D013883
CTD	increases(expression)			HSPA6		D013883
CTD	increases(expression)			HSPA8		D013883
CTD	increases(expression)			HSPB1		D013883
CTD	increases(expression)			HSPD1		D013883
CTD	increases(expression)			HSPH1		D013883
CTD	decreases(expression)			IL1A		D013883
CTD	decreases(expression)			IL1B		D013883
CTD	decreases(expression)			MCL1		D013883
CTD	increases(expression)			MCL1		D013883
CTD	decreases(expression)			NFKB1		D013883
CTD	increases(expression)			PMAIP1		D013883
CTD	increases(expression)			PTGS1		D013883
CTD	increases(expression)			SOD1		D013883
CTD	decreases(expression)			TP53		D013883
CTD	decreases(expression)			XRCC2		D013883
PubChem	AR Potency (uM)	uM	10.520	AR	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	4.065	PPARG	-	GI(Protien) :
PubChem	Potency	uM	4.109	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.081	TDP1	-	GI(Protien) :
PubChem	Potency	uM	5.173	TDP1	-	GI(Protien) :
PubChem	Potency	uM	7.177	TDP1	-	GI(Protien) :

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