Tan Lab | DSigDB

Gene Set: D4 : CTD - Phenytoin

Collection

D4 : CTD

Chemical Name

Phenytoin ( From PubChem : PHENYTOIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Approved	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
252.268 g/mol	2	4	2.4272	True

Structure

InChI

InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)

InChIKey

CXOFVDLJLONNDW-UHFFFAOYSA-N

Links

Gene (109 / 218)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(abundance)			ABCB1		D010672
CTD	affects(response to substance)			ABCB1		D010672
CTD	increases(metabolic processing)			ABCB1		D010672
CTD	decreases(activity)			ABCB1		D010672
CTD	affects(response to substance)			ABCC2		D010672
CTD	decreases(expression)			ADAM8		D010672
CTD	decreases(expression)			AFP		D010672
CTD	increases(expression)			ANXA4		D010672
CTD	affects(localization)			BCL2		D010672
CTD	increases(expression)			BCL2		D010672
CTD	decreases(expression)			BMP1		D010672
CTD	decreases(expression)			CALM2		D010672
CTD	decreases(expression)			CAPN5		D010672
CTD	increases(expression)			CASP10		D010672
CTD	decreases(response to substance)			CAT		D010672
CTD	decreases(expression)			CCND1		D010672
CTD	decreases(expression)			CDKN1A		D010672
CTD	decreases(expression)			CELA2A		D010672
CTD	increases(expression)			CKM		D010672
CTD	increases(expression)			COL11A1		D010672
CTD	decreases(expression)			COL18A1		D010672
CTD	decreases(expression)			COL1A1		D010672
CTD	decreases(reaction)			COL1A1		D010672
CTD	increases(expression)			COL1A1		D010672
CTD	increases(expression)			COL1A2		D010672
CTD	decreases(expression)			COL6A1		D010672
CTD	increases(expression)			COL6A1		D010672
CTD	increases(expression)			COL6A2		D010672
CTD	increases(expression)			COL6A3		D010672
CTD	decreases(activity)			CTSB		D010672
CTD	increases(expression)			CTSB		D010672
CTD	decreases(activity)			CTSL		D010672
CTD	increases(expression)			CTSL		D010672
CTD	decreases(activity)			CYP19A1		D010672
CTD	increases(expression)			CYP1A1		D010672
CTD	affects(cotreatment)			CYP1A2		D010672
CTD	affects(response to substance)			CYP1A2		D010672
CTD	affects(reaction)			CYP2B6		D010672
CTD	increases(expression)			CYP2B6		D010672
CTD	increases(reaction)			CYP2B6		D010672
CTD	decreases(reaction)			CYP2B6		D010672
CTD	increases(expression)			CYP2B6		D010672
CTD	increases(activity)			CYP2B6		D010672
CTD	affects(reaction)			CYP2B6		D010672
CTD	increases(expression)			CYP2B6		D010672
CTD	increases(activity)			CYP2B6		D010672
CTD	increases(activity)			CYP2B6		D010672
CTD	increases(expression)			CYP2B6		D010672
CTD	increases(expression)			CYP2B6		D010672
CTD	increases(expression)			CYP2B6		D010672
CTD	increases(hydroxylation)			CYP2C19		D010672
CTD	affects(cotreatment)			CYP2C19		D010672
CTD	affects(response to substance)			CYP2C19		D010672
CTD	decreases(hydroxylation)			CYP2C19		D010672
CTD	decreases(metabolic processing)			CYP2C19		D010672
CTD	affects(metabolic processing)			CYP2C19		D010672
CTD	increases(hydroxylation)			CYP2C19		D010672
CTD	increases(metabolic processing)			CYP2C19		D010672
CTD	decreases(activity)			CYP2C9		D010672
CTD	increases(response to substance)			CYP2C9		D010672
CTD	affects(cotreatment)			CYP2C9		D010672
CTD	affects(response to substance)			CYP2C9		D010672
CTD	decreases(metabolic processing)			CYP2C9		D010672
CTD	decreases(hydroxylation)			CYP2C9		D010672
CTD	decreases(metabolic processing)			CYP2C9		D010672
CTD	increases(response to substance)			CYP2C9		D010672
CTD	affects(metabolic processing)			CYP2C9		D010672
CTD	increases(hydroxylation)			CYP2C9		D010672
CTD	increases(metabolic processing)			CYP2C9		D010672
CTD	affects(reaction)			CYP2C9		D010672
CTD	increases(expression)			CYP2C9		D010672
CTD	increases(activity)			CYP2C9		D010672
CTD	affects(cotreatment)			CYP2D6		D010672
CTD	affects(response to substance)			CYP2D6		D010672
CTD	decreases(reaction)			CYP2E1		D010672
CTD	increases(expression)			CYP2E1		D010672
CTD	affects(cotreatment)			CYP3A4		D010672
CTD	affects(response to substance)			CYP3A4		D010672
CTD	decreases(reaction)			CYP3A4		D010672
CTD	increases(expression)			CYP3A4		D010672
CTD	increases(reaction)			CYP3A4		D010672
CTD	decreases(reaction)			CYP3A4		D010672
CTD	increases(expression)			CYP3A4		D010672
CTD	affects(reaction)			CYP3A4		D010672
CTD	increases(expression)			CYP3A4		D010672
CTD	increases(expression)			CYP3A4		D010672
CTD	increases(reaction)			CYP3A4		D010672
CTD	increases(hydroxylation)			CYP3A4		D010672
CTD	increases(reaction)			CYP3A4		D010672
CTD	increases(activity)			CYP3A4		D010672
CTD	increases(expression)			CYP3A4		D010672
CTD	increases(expression)			CYP3A5		D010672
CTD	increases(expression)			CYP3A7		D010672
CTD	increases(expression)			DAP3		D010672
CTD	decreases(expression)			DAPK2		D010672
CTD	increases(expression)			EOMES		D010672
CTD	affects(response to substance)			EPHX1		D010672
CTD	affects(binding)			F2		D010672
CTD	affects(cotreatment)			F2		D010672
CTD	increases(expression)			F2		D010672
CTD	increases(expression)			FGF5		D010672
CTD	increases(expression)			FGF9		D010672
CTD	increases(expression)			FGFR2		D010672
CTD	increases(expression)			FLRT2		D010672
CTD	decreases(expression)			FMOD		D010672
CTD	increases(expression)			FN1		D010672
CTD	decreases(expression)			FRS3		D010672
CTD	increases(expression)			GSTA1		D010672
CTD	decreases(expression)			GSTK1		D010672
CTD	decreases(expression)			GSTO1		D010672
CTD	affects(response to substance)			HLA-B		D010672
CTD	increases(expression)			IFNGR1		D010672
CTD	increases(expression)			IFNGR2		D010672
CTD	decreases(expression)			IL1B		D010672
CTD	decreases(reaction)			IL1B		D010672
CTD	increases(expression)			INSR		D010672
CTD	decreases(expression)			ITGA2		D010672
CTD	increases(expression)			ITGA8		D010672
CTD	decreases(expression)			ITGB1		D010672
CTD	decreases(activity)			KCNH2		D010672
CTD	increases(expression)			KRT2		D010672
CTD	increases(expression)			LPIN1		D010672
CTD	increases(expression)			MAP1B		D010672
CTD	decreases(phosphorylation)			MAPK1		D010672
CTD	decreases(phosphorylation)			MAPK3		D010672
CTD	increases(expression)			MDK		D010672
CTD	increases(methylation)			MGMT		D010672
CTD	decreases(expression)			MMP1		D010672
CTD	increases(expression)			MMP1		D010672
CTD	decreases(expression)			MMP2		D010672
CTD	decreases(expression)			MMP3		D010672
CTD	increases(expression)			MYC		D010672
CTD	increases(expression)			NCAN		D010672
CTD	affects(binding)			NCOA1		D010672
CTD	increases(reaction)			NCOA1		D010672
CTD	decreases(reaction)			NFKB1		D010672
CTD	increases(activity)			NFKB1		D010672
CTD	increases(localization)			NFKB1		D010672
CTD	increases(expression)			NFKB1		D010672
CTD	decreases(degradation)			NFKBIA		D010672
CTD	affects(reaction)			NR1I2		D010672
CTD	increases(expression)			NR1I2		D010672
CTD	increases(reaction)			NR1I2		D010672
CTD	decreases(reaction)			NR1I2		D010672
CTD	increases(expression)			NR1I2		D010672
CTD	increases(reaction)			NR1I2		D010672
CTD	increases(activity)			NR1I2		D010672
CTD	affects(reaction)			NR1I2		D010672
CTD	increases(expression)			NR1I2		D010672
CTD	affects(reaction)			NR1I2		D010672
CTD	increases(expression)			NR1I2		D010672
CTD	affects(activity)			NR1I2		D010672
CTD	affects(binding)			NR1I2		D010672
CTD	increases(activity)			NR1I2		D010672
CTD	increases(activity)			NR1I2		D010672
CTD	affects(reaction)			NR1I3		D010672
CTD	increases(expression)			NR1I3		D010672
CTD	affects(binding)			NR1I3		D010672
CTD	increases(reaction)			NR1I3		D010672
CTD	increases(activity)			NR1I3		D010672
CTD	increases(activity)			NR1I3		D010672
CTD	increases(expression)			NR1I3		D010672
CTD	increases(localization)			NR1I3		D010672
CTD	affects(reaction)			NR3C1		D010672
CTD	increases(expression)			NR3C1		D010672
CTD	increases(reaction)			NR3C1		D010672
CTD	increases(expression)			NR3C1		D010672
CTD	increases(reaction)			NR3C1		D010672
CTD	increases(expression)			PDGFA		D010672
CTD	increases(expression)			PDGFB		D010672
CTD	increases(expression)			PIP4K2A		D010672
CTD	decreases(expression)			PLAUR		D010672
CTD	decreases(expression)			PLXNB2		D010672
CTD	increases(expression)			PRSS12		D010672
CTD	increases(expression)			PTH		D010672
CTD	decreases(reaction)			RELA		D010672
CTD	increases(activity)			RELA		D010672
CTD	increases(localization)			RELA		D010672
CTD	increases(expression)			RPL28		D010672
CTD	increases(expression)			RPSA		D010672
CTD	increases(expression)			S100A10		D010672
CTD	increases(expression)			S100A4		D010672
CTD	increases(expression)			SC5D		D010672
CTD	affects(response to substance)			SCN1A		D010672
CTD	affects(response to substance)			SCN1A		D010672
CTD	affects(binding)			SCN1B		D010672
CTD	decreases(activity)			SCN1B		D010672
CTD	decreases(response to substance)			SCN1B		D010672
CTD	decreases(activity)			SCN2A		D010672
CTD	affects(binding)			SCN3A		D010672
CTD	decreases(activity)			SCN3A		D010672
CTD	affects(cotreatment)			SELE		D010672
CTD	increases(expression)			SELE		D010672
CTD	affects(binding)			SERPINC1		D010672
CTD	affects(cotreatment)			SERPINC1		D010672
CTD	increases(expression)			SERPINC1		D010672
CTD	increases(expression)			SMC3		D010672
CTD	increases(expression)			SP3		D010672
CTD	decreases(expression)			STAT4		D010672
CTD	increases(expression)			TGFB3		D010672
CTD	increases(expression)			TIMP1		D010672
CTD	increases(expression)			TIMP1		D010672
CTD	increases(expression)			TNF		D010672
CTD	increases(expression)			TP53		D010672
CTD	affects(expression)			UGT1A1		D010672
CTD	increases(expression)			UGT1A1		D010672
CTD	increases(expression)			VCAN		D010672
CTD	decreases(expression)			VEGFB		D010672
CTD	increases(expression)			VIM		D010672
PubChem	Potency	uM	34.376	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	35.481	NR1I2	-	GI(Protien) :
ChEMBL	Activity	-		AQP4	-	Target : CHEMBL5964
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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