Drug Gene Type Source phenytoin ABCB1 Text_Mining(affects(abundance)) CTD phenytoin ABCB1 Text_Mining(affects(response to substance)) CTD phenytoin ABCB1 Text_Mining(increases(metabolic processing)) CTD phenytoin ABCB1 Text_Mining(decreases(activity)) CTD phenytoin ABCC2 Text_Mining(affects(response to substance)) CTD phenytoin ADAM8 Text_Mining(decreases(expression)) CTD phenytoin AFP Text_Mining(decreases(expression)) CTD phenytoin ANXA4 Text_Mining(increases(expression)) CTD phenytoin BCL2 Text_Mining(affects(localization)) CTD phenytoin BCL2 Text_Mining(increases(expression)) CTD phenytoin BMP1 Text_Mining(decreases(expression)) CTD phenytoin CALM2 Text_Mining(decreases(expression)) CTD phenytoin CAPN5 Text_Mining(decreases(expression)) CTD phenytoin CASP10 Text_Mining(increases(expression)) CTD phenytoin CAT Text_Mining(decreases(response to substance)) CTD phenytoin CCND1 Text_Mining(decreases(expression)) CTD phenytoin CDKN1A Text_Mining(decreases(expression)) CTD phenytoin CELA2A Text_Mining(decreases(expression)) CTD phenytoin CKM Text_Mining(increases(expression)) CTD phenytoin COL11A1 Text_Mining(increases(expression)) CTD phenytoin COL18A1 Text_Mining(decreases(expression)) CTD phenytoin COL1A1 Text_Mining(decreases(expression)) CTD phenytoin COL1A1 Text_Mining(decreases(reaction)) CTD phenytoin COL1A1 Text_Mining(increases(expression)) CTD phenytoin COL1A2 Text_Mining(increases(expression)) CTD phenytoin COL6A1 Text_Mining(decreases(expression)) CTD phenytoin COL6A1 Text_Mining(increases(expression)) CTD phenytoin COL6A2 Text_Mining(increases(expression)) CTD phenytoin COL6A3 Text_Mining(increases(expression)) CTD phenytoin CTSB Text_Mining(decreases(activity)) CTD phenytoin CTSB Text_Mining(increases(expression)) CTD phenytoin CTSL Text_Mining(decreases(activity)) CTD phenytoin CTSL Text_Mining(increases(expression)) CTD phenytoin CYP19A1 Text_Mining(decreases(activity)) CTD phenytoin CYP1A1 Text_Mining(increases(expression)) CTD phenytoin CYP1A2 Text_Mining(affects(cotreatment)) CTD phenytoin CYP1A2 Text_Mining(affects(response to substance)) CTD phenytoin CYP2B6 Text_Mining(affects(reaction)) CTD phenytoin CYP2B6 Text_Mining(increases(expression)) CTD phenytoin CYP2B6 Text_Mining(increases(reaction)) CTD phenytoin CYP2B6 Text_Mining(decreases(reaction)) CTD phenytoin CYP2B6 Text_Mining(increases(activity)) CTD phenytoin CYP2C19 Text_Mining(increases(hydroxylation)) CTD phenytoin CYP2C19 Text_Mining(affects(cotreatment)) CTD phenytoin CYP2C19 Text_Mining(affects(response to substance)) CTD phenytoin CYP2C19 Text_Mining(decreases(hydroxylation)) CTD phenytoin CYP2C19 Text_Mining(decreases(metabolic processing)) CTD phenytoin CYP2C19 Text_Mining(affects(metabolic processing)) CTD phenytoin CYP2C19 Text_Mining(increases(metabolic processing)) CTD phenytoin CYP2C9 Text_Mining(decreases(activity)) CTD phenytoin CYP2C9 Text_Mining(increases(response to substance)) CTD phenytoin CYP2C9 Text_Mining(affects(cotreatment)) CTD phenytoin CYP2C9 Text_Mining(affects(response to substance)) CTD phenytoin CYP2C9 Text_Mining(decreases(metabolic processing)) CTD phenytoin CYP2C9 Text_Mining(decreases(hydroxylation)) CTD phenytoin CYP2C9 Text_Mining(affects(metabolic processing)) CTD phenytoin CYP2C9 Text_Mining(increases(hydroxylation)) CTD phenytoin CYP2C9 Text_Mining(increases(metabolic processing)) CTD phenytoin CYP2C9 Text_Mining(affects(reaction)) CTD phenytoin CYP2C9 Text_Mining(increases(expression)) CTD phenytoin CYP2C9 Text_Mining(increases(activity)) CTD phenytoin CYP2D6 Text_Mining(affects(cotreatment)) CTD phenytoin CYP2D6 Text_Mining(affects(response to substance)) CTD phenytoin CYP2E1 Text_Mining(decreases(reaction)) CTD phenytoin CYP2E1 Text_Mining(increases(expression)) CTD phenytoin CYP3A4 Text_Mining(affects(cotreatment)) CTD phenytoin CYP3A4 Text_Mining(affects(response to substance)) CTD phenytoin CYP3A4 Text_Mining(decreases(reaction)) CTD phenytoin CYP3A4 Text_Mining(increases(expression)) CTD phenytoin CYP3A4 Text_Mining(increases(reaction)) CTD phenytoin CYP3A4 Text_Mining(affects(reaction)) CTD phenytoin CYP3A4 Text_Mining(increases(hydroxylation)) CTD phenytoin CYP3A4 Text_Mining(increases(activity)) CTD phenytoin CYP3A5 Text_Mining(increases(expression)) CTD phenytoin CYP3A7 Text_Mining(increases(expression)) CTD phenytoin DAP3 Text_Mining(increases(expression)) CTD phenytoin DAPK2 Text_Mining(decreases(expression)) CTD phenytoin EOMES Text_Mining(increases(expression)) CTD phenytoin EPHX1 Text_Mining(affects(response to substance)) CTD phenytoin F2 Text_Mining(affects(binding)) CTD phenytoin F2 Text_Mining(affects(cotreatment)) CTD phenytoin F2 Text_Mining(increases(expression)) CTD phenytoin FGF5 Text_Mining(increases(expression)) CTD phenytoin FGF9 Text_Mining(increases(expression)) CTD phenytoin FGFR2 Text_Mining(increases(expression)) CTD phenytoin FLRT2 Text_Mining(increases(expression)) CTD phenytoin FMOD Text_Mining(decreases(expression)) CTD phenytoin FN1 Text_Mining(increases(expression)) CTD phenytoin FRS3 Text_Mining(decreases(expression)) CTD phenytoin GSTA1 Text_Mining(increases(expression)) CTD phenytoin GSTK1 Text_Mining(decreases(expression)) CTD phenytoin GSTO1 Text_Mining(decreases(expression)) CTD phenytoin HLA-B Text_Mining(affects(response to substance)) CTD phenytoin IFNGR1 Text_Mining(increases(expression)) CTD phenytoin IFNGR2 Text_Mining(increases(expression)) CTD phenytoin IL1B Text_Mining(decreases(expression)) CTD phenytoin IL1B Text_Mining(decreases(reaction)) CTD phenytoin INSR Text_Mining(increases(expression)) CTD phenytoin ITGA2 Text_Mining(decreases(expression)) CTD phenytoin ITGA8 Text_Mining(increases(expression)) CTD phenytoin ITGB1 Text_Mining(decreases(expression)) CTD phenytoin KCNH2 Text_Mining(decreases(activity)) CTD phenytoin KRT2 Text_Mining(increases(expression)) CTD phenytoin RPSA Text_Mining(increases(expression)) CTD phenytoin LPIN1 Text_Mining(increases(expression)) CTD phenytoin MAP1B Text_Mining(increases(expression)) CTD phenytoin MAPK1 Text_Mining(decreases(phosphorylation)) CTD phenytoin MAPK3 Text_Mining(decreases(phosphorylation)) CTD phenytoin MDK Text_Mining(increases(expression)) CTD phenytoin MGMT Text_Mining(increases(methylation)) CTD phenytoin MMP1 Text_Mining(decreases(expression)) CTD phenytoin MMP1 Text_Mining(increases(expression)) CTD phenytoin MMP2 Text_Mining(decreases(expression)) CTD phenytoin MMP3 Text_Mining(decreases(expression)) CTD phenytoin MYC Text_Mining(increases(expression)) CTD phenytoin NCAN Text_Mining(increases(expression)) CTD phenytoin NCOA1 Text_Mining(affects(binding)) CTD phenytoin NCOA1 Text_Mining(increases(reaction)) CTD phenytoin NFKB1 Text_Mining(decreases(reaction)) CTD phenytoin NFKB1 Text_Mining(increases(activity)) CTD phenytoin NFKB1 Text_Mining(increases(localization)) CTD phenytoin NFKB1 Text_Mining(increases(expression)) CTD phenytoin NFKBIA Text_Mining(decreases(degradation)) CTD phenytoin NR1I2 Text_Mining(affects(reaction)) CTD phenytoin NR1I2 Text_Mining(increases(expression)) CTD phenytoin NR1I2 Text_Mining(increases(reaction)) CTD phenytoin NR1I2 Text_Mining(decreases(reaction)) CTD phenytoin NR1I2 Text_Mining(increases(activity)) CTD phenytoin NR1I2 Text_Mining(affects(activity)) CTD phenytoin NR1I2 Text_Mining(affects(binding)) CTD phenytoin NR1I3 Text_Mining(affects(reaction)) CTD phenytoin NR1I3 Text_Mining(increases(expression)) CTD phenytoin NR1I3 Text_Mining(affects(binding)) CTD phenytoin NR1I3 Text_Mining(increases(reaction)) CTD phenytoin NR1I3 Text_Mining(increases(activity)) CTD phenytoin NR1I3 Text_Mining(increases(localization)) CTD phenytoin NR3C1 Text_Mining(affects(reaction)) CTD phenytoin NR3C1 Text_Mining(increases(expression)) CTD phenytoin NR3C1 Text_Mining(increases(reaction)) CTD phenytoin PDGFA Text_Mining(increases(expression)) CTD phenytoin PDGFB Text_Mining(increases(expression)) CTD phenytoin PIP4K2A Text_Mining(increases(expression)) CTD phenytoin PLAUR Text_Mining(decreases(expression)) CTD phenytoin PLXNB2 Text_Mining(decreases(expression)) CTD phenytoin PRSS12 Text_Mining(increases(expression)) CTD phenytoin PTH Text_Mining(increases(expression)) CTD phenytoin RELA Text_Mining(decreases(reaction)) CTD phenytoin RELA Text_Mining(increases(activity)) CTD phenytoin RELA Text_Mining(increases(localization)) CTD phenytoin RPL28 Text_Mining(increases(expression)) CTD phenytoin S100A10 Text_Mining(increases(expression)) CTD phenytoin S100A4 Text_Mining(increases(expression)) CTD phenytoin SC5D Text_Mining(increases(expression)) CTD phenytoin SCN1A Text_Mining(affects(response to substance)) CTD phenytoin SCN1B Text_Mining(affects(binding)) CTD phenytoin SCN1B Text_Mining(decreases(activity)) CTD phenytoin SCN1B Text_Mining(decreases(response to substance)) CTD phenytoin SCN2A Text_Mining(decreases(activity)) CTD phenytoin SCN3A Text_Mining(affects(binding)) CTD phenytoin SCN3A Text_Mining(decreases(activity)) CTD phenytoin SELE Text_Mining(affects(cotreatment)) CTD phenytoin SELE Text_Mining(increases(expression)) CTD phenytoin SERPINC1 Text_Mining(affects(binding)) CTD phenytoin SERPINC1 Text_Mining(affects(cotreatment)) CTD phenytoin SERPINC1 Text_Mining(increases(expression)) CTD phenytoin SMC3 Text_Mining(increases(expression)) CTD phenytoin SP3 Text_Mining(increases(expression)) CTD phenytoin STAT4 Text_Mining(decreases(expression)) CTD phenytoin TGFB3 Text_Mining(increases(expression)) CTD phenytoin TIMP1 Text_Mining(increases(expression)) CTD phenytoin TNF Text_Mining(increases(expression)) CTD phenytoin TP53 Text_Mining(increases(expression)) CTD phenytoin UGT1A1 Text_Mining(affects(expression)) CTD phenytoin UGT1A1 Text_Mining(increases(expression)) CTD phenytoin VCAN Text_Mining(increases(expression)) CTD phenytoin VEGFB Text_Mining(decreases(expression)) CTD phenytoin VIM Text_Mining(increases(expression)) CTD phenytoin AQP4 Activity=None(Unspecified) D4 ChEMBL phenytoin CYP1A2 Inhibition=None(Unspecified) D4 ChEMBL phenytoin CYP2C19 Inhibition=None(Unspecified) D4 ChEMBL phenytoin CYP2C9 Inhibition=None(Unspecified) D4 ChEMBL phenytoin CYP2D6 Inhibition=None(Unspecified) D4 ChEMBL phenytoin CYP3A4 Inhibition=None(Unspecified) D4 ChEMBL phenytoin NFE2L2 Potency=34.3762(uM) D4 PubChem phenytoin NR1I2 Potency-Replicate_1=35.4813(uM) D4 PubChem