Tan Lab | DSigDB

Gene Set: D4 : CTD - Ouabain

Collection

D4 : CTD

Chemical Name

Ouabain ( From PubChem : NSC25485 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
584.652 g/mol	8	12	-1.515	False(1/4)

Structure

InChI

InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3

InChIKey

LPMXVESGRSUGHW-UHFFFAOYSA-N

Links

Gene (130 / 222)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(expression)			A2M		D010042
CTD	decreases(reaction)			ABCB1		D010042
CTD	increases(expression)			ABCB1		D010042
CTD	decreases(response to substance)			ABCB1		D010042
CTD	affects(expression)			ACAA2		D010042
CTD	affects(expression)			ACTA2		D010042
CTD	affects(expression)			ADH1C		D010042
CTD	affects(expression)			ANXA1		D010042
CTD	affects(expression)			ANXA2		D010042
CTD	decreases(expression)			ARAF		D010042
CTD	decreases(expression)			ARIH1		D010042
CTD	affects(expression)			ARPC5		D010042
CTD	increases(expression)			ARRB1		D010042
CTD	affects(expression)			ASAH1		D010042
CTD	affects(cotreatment)			ATP12A		D010042
CTD	decreases(reaction)			ATP12A		D010042
CTD	increases(uptake)			ATP12A		D010042
CTD	decreases(reaction)			ATP1A1		D010042
CTD	increases(expression)			ATP1A1		D010042
CTD	affects(binding)			ATP1A1		D010042
CTD	decreases(reaction)			ATP1A2		D010042
CTD	increases(expression)			ATP1A2		D010042
CTD	affects(binding)			ATP1A2		D010042
CTD	affects(binding)			ATP1A3		D010042
CTD	increases(expression)			ATP1A3		D010042
CTD	affects(cotreatment)			ATP4B		D010042
CTD	decreases(reaction)			ATP4B		D010042
CTD	increases(uptake)			ATP4B		D010042
CTD	affects(expression)			ATP5A1		D010042
CTD	decreases(expression)			BAHD1		D010042
CTD	affects(localization)			BAX		D010042
CTD	affects(binding)			BAX		D010042
CTD	decreases(reaction)			BAX		D010042
CTD	increases(expression)			BAX		D010042
CTD	affects(expression)			CALML5		D010042
CTD	increases(expression)			CANX		D010042
CTD	increases(activity)			CASP3		D010042
CTD	increases(expression)			CASP3		D010042
CTD	decreases(expression)			CCDC14		D010042
CTD	decreases(expression)			CCNA1		D010042
CTD	decreases(expression)			CCNA2		D010042
CTD	decreases(expression)			CDK2		D010042
CTD	decreases(expression)			CDK2		D010042
CTD	decreases(expression)			CDKN1A		D010042
CTD	increases(expression)			CDKN1A		D010042
CTD	decreases(expression)			CLDN1		D010042
CTD	affects(expression)			CNPY2		D010042
CTD	affects(localization)			CYC1		D010042
CTD	decreases(expression)			CYC1		D010042
CTD	decreases(expression)			DDOST		D010042
CTD	decreases(expression)			DRD1		D010042
CTD	increases(phosphorylation)			DRD1		D010042
CTD	affects(expression)			DSG1		D010042
CTD	affects(expression)			DUT		D010042
CTD	increases(expression)			ECE1		D010042
CTD	affects(expression)			ECHS1		D010042
CTD	affects(expression)			EIF3K		D010042
CTD	decreases(expression)			ERCC4		D010042
CTD	affects(ubiquitination)			FANCD2		D010042
CTD	decreases(reaction)			FANCD2		D010042
CTD	increases(expression)			FANCD2		D010042
CTD	decreases(expression)			FANCD2		D010042
CTD	decreases(expression)			FANCF		D010042
CTD	affects(ubiquitination)			FANCI		D010042
CTD	decreases(reaction)			FANCI		D010042
CTD	increases(expression)			FANCI		D010042
CTD	decreases(expression)			FANCI		D010042
CTD	increases(expression)			FARS2		D010042
CTD	affects(expression)			FH		D010042
CTD	increases(expression)			FKBP7		D010042
CTD	affects(expression)			GC		D010042
CTD	increases(expression)			GLRB		D010042
CTD	increases(expression)			GTPBP6		D010042
CTD	affects(localization)			HIF1A		D010042
CTD	decreases(reaction)			HIF1A		D010042
CTD	increases(phosphorylation)			HIF1A		D010042
CTD	increases(activity)			HIF1A		D010042
CTD	increases(expression)			HIF1A		D010042
CTD	affects(expression)			HNRNPA2B1		D010042
CTD	decreases(expression)			HNRNPDL		D010042
CTD	affects(expression)			HPCAL1		D010042
CTD	affects(expression)			HRG		D010042
CTD	affects(expression)			HSPD1		D010042
CTD	affects(binding)			HSPD1		D010042
CTD	decreases(reaction)			HSPD1		D010042
CTD	affects(localization)			HSPD1		D010042
CTD	decreases(expression)			HSPD1		D010042
CTD	decreases(expression)			IL2RA		D010042
CTD	decreases(expression)			IL2RB		D010042
CTD	increases(expression)			KCND2		D010042
CTD	decreases(reaction)			KCNH2		D010042
CTD	increases(transport)			KCNH2		D010042
CTD	decreases(activity)			KCNH2		D010042
CTD	decreases(expression)			KCNH2		D010042
CTD	affects(expression)			LGALS1		D010042
CTD	increases(expression)			LGALS1		D010042
CTD	increases(abundance)			LSS		D010042
CTD	decreases(reaction)			MAPK7		D010042
CTD	increases(activity)			MAPK7		D010042
CTD	increases(phosphorylation)			MAPK7		D010042
CTD	affects(expression)			MDH2		D010042
CTD	decreases(expression)			MYC		D010042
CTD	increases(expression)			MYC		D010042
CTD	increases(expression)			MYL12A		D010042
CTD	decreases(expression)			NPC2		D010042
CTD	increases(cleavage)			PARP1		D010042
CTD	increases(reaction)			PARP1		D010042
CTD	decreases(expression)			PCNA		D010042
CTD	decreases(expression)			PCNA		D010042
CTD	increases(expression)			PDCD6		D010042
CTD	affects(expression)			PFDN5		D010042
CTD	affects(expression)			PFN1		D010042
CTD	decreases(expression)			PFN1		D010042
CTD	decreases(expression)			PPT2		D010042
CTD	affects(expression)			PSMB6		D010042
CTD	decreases(expression)			PTPN2		D010042
CTD	increases(expression)			RAB11B		D010042
CTD	decreases(reaction)			ROCK1		D010042
CTD	increases(cleavage)			ROCK1		D010042
CTD	decreases(reaction)			ROCK2		D010042
CTD	increases(cleavage)			ROCK2		D010042
CTD	affects(expression)			RPA3		D010042
CTD	decreases(expression)			RPGRIP1L		D010042
CTD	affects(expression)			S100A13		D010042
CTD	decreases(reaction)			SGK1		D010042
CTD	increases(transport)			SGK1		D010042
CTD	decreases(reaction)			SGK2		D010042
CTD	increases(transport)			SGK2		D010042
CTD	decreases(reaction)			SGK3		D010042
CTD	increases(transport)			SGK3		D010042
CTD	decreases(reaction)			SLC5A5		D010042
CTD	increases(uptake)			SLC5A5		D010042
CTD	decreases(reaction)			SLC5A6		D010042
CTD	increases(transport)			SLC5A6		D010042
CTD	affects(expression)			TPI1		D010042
CTD	affects(expression)			TPT1		D010042
CTD	affects(expression)			TXN		D010042
CTD	decreases(expression)			ZFHX3		D010042
PubChem	AC50_uM	uM	3.380	CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	None	uM		GALR3	-	GI(Protien) :
PubChem	Potency	uM	6.513	GMNN	-	GI(Protien) :
PubChem	None	uM		HTR5A	-	GI(Protien) :
PubChem	Potency	uM	0.130	IDH1	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	None	uM		MC4R	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	None	uM		NCOA1	-	GI(Protien) :
PubChem	None	uM		NCOA1	-	GI(Protien) :
PubChem	None	uM		NCOA2	-	GI(Protien) :
PubChem	None	uM		NCOA2	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	None	uM		NCOA3	-	GI(Protien) :
PubChem	Potency	uM	0.033	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.058	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NR2F2	-	GI(Protien) :
PubChem	None	uM		NR2F2	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	None	uM		OPRD1	-	GI(Protien) :
PubChem	None	uM		OPRM1	-	GI(Protien) :
PubChem	None	uM		PLA2G3	-	GI(Protien) :
PubChem	Potency	uM	0.206	SMAD3	-	GI(Protien) :
PubChem	Potency	uM	1.122	SMAD3	-	GI(Protien) :
PubChem	Potency	uM	3.663	SMAD3	-	GI(Protien) :
PubChem	Potency	uM	2.060	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.311	TDP1	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	None	uM		APP	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.022	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.039	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.046	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.190	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.213	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	0.779	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.841	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	1.019	AR	-	GI(Protien) :
PubChem	Potency	uM	0.092	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	0.164	ATAD5	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.163	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.249	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.455	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.531	ESR1	-	GI(Protien) :
PubChem	Potency	uM	0.259	GMNN	-	GI(Protien) :
PubChem	IC50	uM	0.030	KLF5	-	GI(Protien) :
PubChem	IC50	uM	0.055	KLF5	-	GI(Protien) :
PubChem	IC50	uM	0.165	KLF5	-	GI(Protien) :
PubChem	None	uM		KLF5	-	GI(Protien) :
PubChem	None	uM		KLF5	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	EC50	uM		NOD1	-	GI(Protien) :
PubChem	EC50	uM		NOD2	-	GI(Protien) :
PubChem	None	uM		NPY1R	-	GI(Protien) :
PubChem	None	uM		NPY2R	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.268	NR3C1	-	GI(Protien) :
PubChem	None	uM		PTBP1	-	GI(Protien) :
PubChem	None	uM		S1PR4	-	GI(Protien) :
PubChem	None	uM		S1PR4	-	GI(Protien) :
PubChem	None	uM		SLC6A3	-	GI(Protien) :
PubChem	None	uM		SLC6A3	-	GI(Protien) :
PubChem	None	uM		SLC6A3	-	GI(Protien) :
PubChem	IC50	uM	1.154	STAT3	-	GI(Protien) :
PubChem	None	uM		STAT3	-	GI(Protien) :
PubChem	None	uM		STAT3	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	0.237	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.266	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.944	TDP1	-	GI(Protien) :
PubChem	Potency	uM	1.679	TDP1	-	GI(Protien) :
PubChem	None	uM		TNF	-	GI(Protien) :
PubChem	None	uM		TNFSF10	-	GI(Protien) :
ChEMBL	Potency	nM	92.000	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	163.600	ATAD5	-	Target : CHEMBL1741209
ChEMBL	IC50	nM	164.550	KLF5	-	Target : CHEMBL1293249
ChEMBL	IC50	nM	1154.000	STAT3	-	Target : CHEMBL4026

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