Tan Lab | DSigDB

Gene Set: D4 : CTD - Nortriptyline

Collection

D4 : CTD

Chemical Name

Nortriptyline ( From PubChem : NORTRIPTYLINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
263.377 g/mol	1	1	4.2173	True

Structure

InChI

InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3

InChIKey

PHVGLTMQBUFIQQ-UHFFFAOYSA-N

Links

Gene (23 / 53)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(response to substance)			ABCB1		D009661
CTD	increases(activity)			CASP3		D009661
CTD	increases(reaction)			CASP3		D009661
CTD	increases(activity)			CASP7		D009661
CTD	increases(reaction)			CASP7		D009661
CTD	increases(metabolic processing)			CYP1A2		D009661
CTD	decreases(activity)			CYP2C8		D009661
CTD	decreases(reaction)			CYP2C8		D009661
CTD	decreases(response to substance)			CYP2D6		D009661
CTD	increases(hydroxylation)			CYP2D6		D009661
CTD	increases(metabolic processing)			CYP2D6		D009661
CTD	decreases(reaction)			CYP2D6		D009661
CTD	increases(metabolic processing)			CYP3A4		D009661
CTD	increases(metabolic processing)			CYP3A5		D009661
CTD	decreases(response to substance)			GNB3		D009661
CTD	increases(response to substance)			GNB3		D009661
CTD	decreases(expression)			HTR2C		D009661
CTD	affects(cotreatment)			IL1A		D009661
CTD	increases(response to substance)			IL1A		D009661
CTD	affects(cotreatment)			IL6		D009661
CTD	increases(response to substance)			IL6		D009661
CTD	decreases(reaction)			KCNH2		D009661
CTD	increases(transport)			KCNH2		D009661
CTD	affects(expression)			PF4		D009661
CTD	affects(expression)			PPBP		D009661
CTD	decreases(reaction)			SLC22A2		D009661
CTD	increases(uptake)			SLC22A2		D009661
CTD	affects(response to substance)			SLC6A2		D009661
CTD	decreases(response to substance)			SLC6A4		D009661
CTD	affects(response to substance)			SLC6A4		D009661
CTD	affects(response to substance)			SLC6A4		D009661
CTD	increases(response to substance)			SLC6A4		D009661
CTD	affects(cotreatment)			TNF		D009661
CTD	increases(response to substance)			TNF		D009661
PubChem	Potency	uM	15.849	ATXN2	-	GI(Protien) :
PubChem	Potency	uM	17.783	ATXN2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	19.953	DRD1	-	GI(Protien) :
PubChem	Potency	uM	20.596	TDP1	-	GI(Protien) :
PubChem	Potency	uM	19.953	TP53	-	GI(Protien) :
PubChem	Potency	uM	19.953	TP53	-	GI(Protien) :
ChEMBL	AC50	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	6309.570	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3162.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	6309.600	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	19952.600	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	19952.600	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	19952.600	TP53	-	Target : CHEMBL4096

Download gene sets

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