Tan Lab | DSigDB

Gene Set: D4 : CTD - Metyrapone

Collection

D4 : CTD

Chemical Name

Metyrapone ( From PubChem : METYRAPONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
226.274 g/mol	0	3	2.6371	True

Structure

InChI

InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3

InChIKey

Links

Gene (14 / 31)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(activity)			ABCC3		D008797
CTD	increases(expression)			ABCC3		D008797
CTD	increases(expression)			ATF6		D008797
CTD	increases(reaction)			ATF6		D008797
CTD	affects(cotreatment)			CASP4		D008797
CTD	affects(localization)			CASP4		D008797
CTD	increases(activity)			CYP3A4		D008797
CTD	increases(expression)			CYP3A4		D008797
CTD	increases(expression)			CYP3A4		D008797
CTD	affects(cotreatment)			DDIT3		D008797
CTD	increases(expression)			DDIT3		D008797
CTD	increases(reaction)			DDIT3		D008797
CTD	increases(reduction)			DHRS7		D008797
CTD	decreases(activity)			HSD11B1		D008797
CTD	decreases(activity)			HSD11B2		D008797
CTD	increases(expression)			HSPA5		D008797
CTD	increases(reaction)			HSPA5		D008797
CTD	affects(cotreatment)			MAP1LC3B		D008797
CTD	increases(expression)			MAP1LC3B		D008797
CTD	increases(activity)			NR1I2		D008797
CTD	increases(activity)			NR1I2		D008797
CTD	increases(expression)			NR1I2		D008797
CTD	increases(activity)			NR1I2		D008797
CTD	increases(expression)			NR1I2		D008797
CTD	increases(activity)			NR1I3		D008797
CTD	increases(expression)			POMC		D008797
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	1.259	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
ChEMBL	Potency	nM	1258.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	1258.930	CYP3A4	-	Target : CHEMBL340

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