Tan Lab | DSigDB

Gene Set: D4 : CTD - Melphalan

Collection

D4 : CTD

Chemical Name

Melphalan ( From PubChem : MELPHALAN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
305.2 g/mol	2	4	2.6253	True

Structure

InChI

InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1

InChIKey

SGDBTWWWUNNDEQ-LBPRGKRZSA-N

Links

Gene (279 / 304)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(export)			ABCC1		D008558
CTD	decreases(expression)			ABHD17C		D008558
CTD	increases(expression)			ABT1		D008558
CTD	increases(expression)			ACKR3		D008558
CTD	decreases(expression)			ACVR1C		D008558
CTD	decreases(expression)			AHRR		D008558
CTD	decreases(activity)			ALAD		D008558
CTD	increases(expression)			AMMECR1L		D008558
CTD	decreases(expression)			ANKAR		D008558
CTD	increases(expression)			ANKRD10		D008558
CTD	decreases(expression)			ANKRD28		D008558
CTD	decreases(expression)			ANKRD34A		D008558
CTD	decreases(expression)			AR		D008558
CTD	decreases(expression)			ARHGAP12		D008558
CTD	decreases(expression)			ARHGAP18		D008558
CTD	decreases(expression)			ARHGAP20		D008558
CTD	decreases(expression)			ARHGAP24		D008558
CTD	increases(expression)			ARID5A		D008558
CTD	increases(expression)			ATG16L1		D008558
CTD	decreases(expression)			ATP1A1-AS1		D008558
CTD	decreases(expression)			ATP2B1		D008558
CTD	increases(expression)			B3GNT2		D008558
CTD	increases(expression)			B3GNT5		D008558
CTD	increases(expression)			BAK1		D008558
CTD	decreases(localization)			BAX		D008558
CTD	increases(expression)			BAX		D008558
CTD	affects(cotreatment)			BCHE		D008558
CTD	decreases(expression)			BCHE		D008558
CTD	decreases(expression)			BCL2		D008558
CTD	increases(expression)			BCL2A1		D008558
CTD	decreases(expression)			BICC1		D008558
CTD	affects(response to substance)			BIRC5		D008558
CTD	affects(reaction)			BIRC5		D008558
CTD	decreases(expression)			BNC2		D008558
CTD	increases(expression)			BTG2		D008558
CTD	increases(expression)			C10ORF2		D008558
CTD	decreases(expression)			C6ORF165		D008558
CTD	decreases(expression)			CABLES1		D008558
CTD	increases(activity)			CASP3		D008558
CTD	increases(activity)			CASP9		D008558
CTD	increases(cleavage)			CASP9		D008558
CTD	decreases(activity)			CAT		D008558
CTD	decreases(expression)			CC2D2A		D008558
CTD	decreases(expression)			CCDC110		D008558
CTD	decreases(expression)			CCDC171		D008558
CTD	increases(expression)			CCDC64B		D008558
CTD	increases(expression)			CCL20		D008558
CTD	increases(expression)			CCNJ		D008558
CTD	affects(cotreatment)			CD34		D008558
CTD	decreases(expression)			CD34		D008558
CTD	decreases(response to substance)			CDA		D008558
CTD	decreases(expression)			CDC14B		D008558
CTD	decreases(expression)			CDC42EP3		D008558
CTD	affects(phosphorylation)			CHUK		D008558
CTD	decreases(expression)			CIITA		D008558
CTD	increases(expression)			CITED4		D008558
CTD	decreases(expression)			CNKSR3		D008558
CTD	decreases(expression)			CPNE8		D008558
CTD	decreases(expression)			CREB5		D008558
CTD	increases(expression)			CUL3		D008558
CTD	decreases(expression)			CXCL12		D008558
CTD	decreases(expression)			CXORF57		D008558
CTD	increases(expression)			CYCSP39		D008558
CTD	decreases(reaction)			CYP1A1		D008558
CTD	increases(activity)			CYP1A1		D008558
CTD	decreases(reaction)			CYP1A2		D008558
CTD	increases(activity)			CYP1A2		D008558
CTD	increases(expression)			CYP27B1		D008558
CTD	increases(expression)			DBF4		D008558
CTD	decreases(expression)			DENND4C		D008558
CTD	increases(expression)			DIEXF		D008558
CTD	decreases(expression)			DLG3		D008558
CTD	increases(expression)			DOCK9-AS2		D008558
CTD	decreases(expression)			DST		D008558
CTD	increases(expression)			DUSP2		D008558
CTD	increases(expression)			EAF1		D008558
CTD	decreases(expression)			EBF1		D008558
CTD	increases(expression)			EDN1		D008558
CTD	decreases(expression)			EEPD1		D008558
CTD	increases(expression)			EFNA2		D008558
CTD	decreases(expression)			EFNA5		D008558
CTD	decreases(expression)			EMX2		D008558
CTD	decreases(expression)			ENOX1		D008558
CTD	decreases(expression)			EPHA5		D008558
CTD	decreases(expression)			EXOC6		D008558
CTD	increases(expression)			FABP5		D008558
CTD	decreases(expression)			FAM110B		D008558
CTD	decreases(expression)			FAM175A		D008558
CTD	decreases(expression)			FAM49A		D008558
CTD	decreases(expression)			FAM65B		D008558
CTD	decreases(expression)			FAM90A1		D008558
CTD	increases(response to substance)			FANCC		D008558
CTD	increases(response to substance)			FANCG		D008558
CTD	decreases(expression)			FAT4		D008558
CTD	decreases(expression)			FGD4		D008558
CTD	decreases(expression)			FGD6		D008558
CTD	decreases(expression)			FGF5		D008558
CTD	decreases(expression)			FIGN		D008558
CTD	decreases(expression)			FMN2		D008558
CTD	increases(expression)			FOSB		D008558
CTD	decreases(expression)			FOXP2		D008558
CTD	decreases(expression)			FRMD4A		D008558
CTD	decreases(expression)			FRMD4B		D008558
CTD	decreases(expression)			FRY		D008558
CTD	decreases(expression)			FUT10		D008558
CTD	decreases(expression)			GAB1		D008558
CTD	decreases(expression)			GAREM		D008558
CTD	decreases(expression)			GAS1		D008558
CTD	decreases(expression)			GCNT1		D008558
CTD	decreases(expression)			GLI3		D008558
CTD	increases(expression)			GRIN2C		D008558
CTD	decreases(expression)			GRK5		D008558
CTD	decreases(response to substance)			GSTM1		D008558
CTD	affects(cotreatment)			GSTP1		D008558
CTD	increases(response to substance)			GSTP1		D008558
CTD	decreases(reaction)			GSTP1		D008558
CTD	increases(metabolic processing)			GSTP1		D008558
CTD	decreases(expression)			HECW2		D008558
CTD	decreases(expression)			HGF		D008558
CTD	decreases(expression)			HMGA2		D008558
CTD	increases(expression)			HOXD1		D008558
CTD	increases(expression)			ICAM1		D008558
CTD	increases(expression)			IER3		D008558
CTD	decreases(expression)			IKBKE		D008558
CTD	decreases(expression)			IKZF2		D008558
CTD	increases(expression)			IL12A		D008558
CTD	decreases(expression)			IL16		D008558
CTD	increases(expression)			IL1B		D008558
CTD	decreases(expression)			IL7		D008558
CTD	decreases(expression)			IRF2		D008558
CTD	decreases(expression)			JADE2		D008558
CTD	decreases(expression)			JAK2		D008558
CTD	decreases(expression)			JAKMIP3		D008558
CTD	decreases(expression)			KALRN		D008558
CTD	decreases(expression)			KBTBD3		D008558
CTD	decreases(expression)			KIAA0922		D008558
CTD	decreases(expression)			KIAA1107		D008558
CTD	decreases(expression)			KITLG		D008558
CTD	decreases(expression)			KLF12		D008558
CTD	increases(expression)			KLHL42		D008558
CTD	increases(expression)			LINC00312		D008558
CTD	decreases(expression)			LRIG3		D008558
CTD	decreases(expression)			LURAP1		D008558
CTD	decreases(expression)			LYST		D008558
CTD	increases(activity)			MAPK1		D008558
CTD	increases(phosphorylation)			MAPK1		D008558
CTD	increases(activity)			MAPK3		D008558
CTD	increases(phosphorylation)			MAPK3		D008558
CTD	decreases(expression)			MBOAT1		D008558
CTD	decreases(expression)			MEOX2		D008558
CTD	increases(expression)			MESDC1		D008558
CTD	increases(expression)			MEX3A		D008558
CTD	increases(expression)			MEX3B		D008558
CTD	increases(expression)			MFSD2A		D008558
CTD	decreases(response to substance)			MGST2		D008558
CTD	increases(expression)			MIR17HG		D008558
CTD	decreases(expression)			MITF		D008558
CTD	decreases(expression)			MKL2		D008558
CTD	decreases(expression)			MLLT3		D008558
CTD	decreases(expression)			MMS22L		D008558
CTD	decreases(expression)			MTA3		D008558
CTD	decreases(expression)			MTCL1		D008558
CTD	decreases(expression)			MYO1B		D008558
CTD	decreases(expression)			NEAT1		D008558
CTD	increases(expression)			NEBL		D008558
CTD	decreases(expression)			NFIA		D008558
CTD	decreases(expression)			NHS		D008558
CTD	increases(expression)			NKRF		D008558
CTD	increases(expression)			NOP56		D008558
CTD	increases(expression)			NPPB		D008558
CTD	increases(expression)			NR4A3		D008558
CTD	decreases(expression)			NRG2		D008558
CTD	decreases(expression)			NRP1		D008558
CTD	decreases(expression)			NUAK1		D008558
CTD	decreases(expression)			OSBPL10		D008558
CTD	decreases(expression)			PAG1		D008558
CTD	decreases(expression)			PDLIM5		D008558
CTD	decreases(expression)			PHF21A		D008558
CTD	decreases(expression)			PHF3		D008558
CTD	increases(expression)			PHLDA1		D008558
CTD	decreases(expression)			PHLDB2		D008558
CTD	decreases(expression)			PIK3R1		D008558
CTD	decreases(expression)			PIK3R3		D008558
CTD	decreases(expression)			PLCL2		D008558
CTD	decreases(expression)			PLEKHA2		D008558
CTD	decreases(expression)			PLEKHA5		D008558
CTD	increases(expression)			PLK3		D008558
CTD	increases(expression)			PPIF		D008558
CTD	decreases(expression)			PPM1H		D008558
CTD	decreases(expression)			PPP2R2B		D008558
CTD	decreases(expression)			PPP2R5A		D008558
CTD	decreases(expression)			PRUNE2		D008558
CTD	decreases(expression)			PSD3		D008558
CTD	increases(expression)			PTGS2		D008558
CTD	decreases(expression)			PTPRG		D008558
CTD	decreases(expression)			PXK		D008558
CTD	decreases(expression)			RAD54B		D008558
CTD	decreases(expression)			RARB		D008558
CTD	increases(expression)			RASD1		D008558
CTD	increases(expression)			RASL10A		D008558
CTD	increases(expression)			RASL11B		D008558
CTD	increases(expression)			RBM24		D008558
CTD	decreases(expression)			REV3L		D008558
CTD	decreases(expression)			RGL1		D008558
CTD	decreases(expression)			RGMB		D008558
CTD	increases(expression)			RGS16		D008558
CTD	increases(expression)			RGS2		D008558
CTD	decreases(expression)			RNF128		D008558
CTD	decreases(expression)			RNF144B		D008558
CTD	decreases(expression)			ROR1		D008558
CTD	increases(expression)			RPL27A		D008558
CTD	increases(expression)			RRAD		D008558
CTD	decreases(expression)			RSPO2		D008558
CTD	decreases(expression)			RUNX1T1		D008558
CTD	decreases(expression)			SCN8A		D008558
CTD	decreases(expression)			SEMA6D		D008558
CTD	increases(expression)			SERPINB2		D008558
CTD	increases(expression)			SGK1		D008558
CTD	decreases(expression)			SGMS1		D008558
CTD	decreases(expression)			SHANK2		D008558
CTD	decreases(expression)			SHROOM3		D008558
CTD	increases(expression)			SIK1		D008558
CTD	decreases(expression)			SLC14A1		D008558
CTD	increases(expression)			SLC19A2		D008558
CTD	decreases(reaction)			SMAD2		D008558
CTD	increases(phosphorylation)			SMAD2		D008558
CTD	decreases(expression)			SMAD3		D008558
CTD	increases(expression)			SNHG15		D008558
CTD	increases(expression)			SNORA70		D008558
CTD	increases(expression)			SNORD14E		D008558
CTD	increases(expression)			SNORD22		D008558
CTD	decreases(expression)			SNTB1		D008558
CTD	decreases(expression)			SNX29		D008558
CTD	decreases(expression)			SOCS5		D008558
CTD	decreases(expression)			SPATA17		D008558
CTD	decreases(expression)			SPATA7		D008558
CTD	decreases(expression)			SPRED1		D008558
CTD	increases(expression)			SPTY2D1		D008558
CTD	decreases(expression)			SRGAP2		D008558
CTD	decreases(expression)			STAC		D008558
CTD	decreases(expression)			STAMBPL1		D008558
CTD	decreases(expression)			TACC2		D008558
CTD	decreases(expression)			TBC1D12		D008558
CTD	decreases(expression)			TBL1XR1		D008558
CTD	decreases(expression)			TET1		D008558
CTD	increases(expression)			TEX30		D008558
CTD	increases(expression)			TFPI2		D008558
CTD	decreases(expression)			THSD4		D008558
CTD	decreases(expression)			TIGD2		D008558
CTD	decreases(expression)			TLR4		D008558
CTD	decreases(expression)			TMEM133		D008558
CTD	decreases(expression)			TMEM200A		D008558
CTD	decreases(expression)			TMEM26		D008558
CTD	increases(expression)			TMEM88		D008558
CTD	increases(expression)			TNF		D008558
CTD	decreases(expression)			TNFRSF19		D008558
CTD	increases(expression)			TNNI3		D008558
CTD	decreases(expression)			TNRC6B		D008558
CTD	decreases(expression)			TOX		D008558
CTD	decreases(expression)			TP63		D008558
CTD	decreases(expression)			TRERF1		D008558
CTD	increases(expression)			TRIB1		D008558
CTD	increases(expression)			TRMT10C		D008558
CTD	decreases(expression)			TTC30B		D008558
CTD	increases(expression)			TUFT1		D008558
CTD	increases(expression)			UBAP1L		D008558
CTD	increases(expression)			USP36		D008558
CTD	decreases(expression)			USP53		D008558
CTD	increases(expression)			VDAC1		D008558
CTD	increases(response to substance)			VDAC1		D008558
CTD	increases(expression)			YOD1		D008558
CTD	decreases(expression)			YPEL2		D008558
CTD	increases(expression)			YRDC		D008558
CTD	decreases(expression)			ZBTB20		D008558
CTD	increases(expression)			ZC3H12A		D008558
CTD	decreases(expression)			ZFHX4		D008558
CTD	decreases(expression)			ZNF214		D008558
CTD	decreases(expression)			ZNF277		D008558
CTD	decreases(expression)			ZNF438		D008558
CTD	decreases(expression)			ZNF521		D008558
CTD	decreases(expression)			ZNF618		D008558
CTD	decreases(expression)			ZSWIM5		D008558
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	26.603	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	26.832	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	29.849	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	30.107	AR	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	7.943	EHMT2	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	17.495	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.330	ESR1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	Potency	uM	42.163	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	54.483	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	39.811	NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	44.668	NR1I2	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	0.231	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.259	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.531	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.531	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	3162.300	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	7943.300	EHMT2	-	Target : CHEMBL6032

Download gene sets

gmt, text, Detailed text