Tan Lab | DSigDB

Gene Set: D4 : CTD - Ibuprofen

Collection

D4 : CTD

Chemical Name

Ibuprofen ( From PubChem : IBUPROFEN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Approved	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
206.281 g/mol	1	2	3.0732	True

Structure

InChI

InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m1/s1

InChIKey

HEFNNWSXXWATRW-SNVBAGLBSA-N

Links

Gene (149 / 322)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ADAMTS8		D007052
CTD	decreases(activity)			AKR1C1		D007052
CTD	decreases(activity)			AKR1C2		D007052
CTD	decreases(activity)			AKR1C3		D007052
CTD	affects(binding)			ALB		D007052
CTD	decreases(reaction)			ALB		D007052
CTD	affects(expression)			ALOX12B		D007052
CTD	affects(expression)			ALOXE3		D007052
CTD	affects(response to substance)			AMACR		D007052
CTD	increases(activity)			AMACR		D007052
CTD	increases(metabolic processing)			AMACR		D007052
CTD	increases(metabolic processing)			AMACR		D007052
CTD	affects(expression)			ANXA1		D007052
CTD	affects(expression)			ANXA2		D007052
CTD	affects(expression)			ANXA3		D007052
CTD	decreases(expression)			ANXA9		D007052
CTD	affects(cleavage)			APP		D007052
CTD	affects(cotreatment)			APP		D007052
CTD	decreases(reaction)			APP		D007052
CTD	increases(metabolic processing)			APP		D007052
CTD	increases(secretion)			APP		D007052
CTD	decreases(expression)			APP		D007052
CTD	affects(cotreatment)			BACE1		D007052
CTD	decreases(reaction)			BACE1		D007052
CTD	increases(expression)			BACE1		D007052
CTD	increases(activity)			BACE1		D007052
CTD	decreases(activity)			BACE1		D007052
CTD	decreases(expression)			BACE1		D007052
CTD	affects(cotreatment)			BCL2L1		D007052
CTD	decreases(expression)			BCL2L1		D007052
CTD	decreases(reaction)			BCL2L1		D007052
CTD	increases(expression)			BCL2L1		D007052
CTD	affects(expression)			C3		D007052
CTD	affects(expression)			CACNA2D3		D007052
CTD	decreases(reaction)			CCL2		D007052
CTD	increases(secretion)			CCL2		D007052
CTD	increases(expression)			CCL2		D007052
CTD	decreases(reaction)			CCL3		D007052
CTD	increases(expression)			CCL3		D007052
CTD	decreases(reaction)			CCND1		D007052
CTD	increases(expression)			CCND1		D007052
CTD	increases(expression)			CD36		D007052
CTD	affects(expression)			CDH3		D007052
CTD	affects(expression)			CDSN		D007052
CTD	affects(expression)			CEACAM1		D007052
CTD	decreases(reaction)			CHUK		D007052
CTD	increases(activity)			CHUK		D007052
CTD	decreases(activity)			CHUK		D007052
CTD	increases(activity)			CHUK		D007052
CTD	affects(expression)			CLU		D007052
CTD	affects(binding)			CNR2		D007052
CTD	decreases(reaction)			CNR2		D007052
CTD	affects(expression)			COL11A1		D007052
CTD	affects(expression)			CX3CL1		D007052
CTD	decreases(reaction)			CXCL10		D007052
CTD	increases(expression)			CXCL10		D007052
CTD	decreases(activity)			CYP19A1		D007052
CTD	decreases(expression)			CYP19A1		D007052
CTD	affects(metabolic processing)			CYP2C8		D007052
CTD	decreases(metabolic processing)			CYP2C8		D007052
CTD	increases(metabolic processing)			CYP2C8		D007052
CTD	decreases(metabolic processing)			CYP2C9		D007052
CTD	affects(binding)			CYP2C9		D007052
CTD	affects(metabolic processing)			CYP2C9		D007052
CTD	increases(metabolic processing)			CYP2C9		D007052
CTD	affects(metabolic processing)			CYP2C9		D007052
CTD	decreases(reaction)			CYP2C9		D007052
CTD	affects(expression)			DDX1		D007052
CTD	affects(expression)			DEFB4A		D007052
CTD	affects(expression)			DSC1		D007052
CTD	decreases(reaction)			EGF		D007052
CTD	increases(activity)			EGF		D007052
CTD	increases(expression)			EGF		D007052
CTD	increases(phosphorylation)			EIF4E		D007052
CTD	increases(reaction)			EIF4E		D007052
CTD	increases(expression)			ELAVL1		D007052
CTD	increases(reaction)			ELAVL1		D007052
CTD	affects(binding)			ELAVL1		D007052
CTD	affects(expression)			ENO1		D007052
CTD	decreases(expression)			EPAS1		D007052
CTD	affects(expression)			EPHB6		D007052
CTD	affects(cleavage)			ERBB4		D007052
CTD	increases(expression)			F3		D007052
CTD	decreases(expression)			FABP4		D007052
CTD	affects(expression)			FASN		D007052
CTD	decreases(expression)			FASN		D007052
CTD	increases(expression)			FOSB		D007052
CTD	affects(expression)			FRZB		D007052
CTD	increases(expression)			GCLC		D007052
CTD	increases(expression)			GCLM		D007052
CTD	decreases(reaction)			GDF15		D007052
CTD	increases(expression)			GDF15		D007052
CTD	increases(expression)			GDF15		D007052
CTD	increases(reaction)			GDF15		D007052
CTD	decreases(expression)			HIF1A		D007052
CTD	affects(expression)			HPGD		D007052
CTD	increases(activity)			HPGD		D007052
CTD	increases(expression)			HPGD		D007052
CTD	increases(activity)			HSF1		D007052
CTD	affects(localization)			HSPA1A		D007052
CTD	increases(expression)			HSPA1A		D007052
CTD	increases(expression)			HSPA7		D007052
CTD	affects(localization)			HSPA8		D007052
CTD	decreases(reaction)			ICAM1		D007052
CTD	increases(expression)			ICAM1		D007052
CTD	decreases(expression)			ICAM1		D007052
CTD	affects(cotreatment)			IFNG		D007052
CTD	decreases(reaction)			IFNG		D007052
CTD	increases(expression)			IFNG		D007052
CTD	increases(metabolic processing)			IFNG		D007052
CTD	increases(secretion)			IFNG		D007052
CTD	increases(activity)			IFNG		D007052
CTD	affects(expression)			IGHG3		D007052
CTD	affects(expression)			IGKC		D007052
CTD	affects(expression)			IGKV1-5		D007052
CTD	affects(expression)			IGLC1		D007052
CTD	affects(expression)			IGLJ3		D007052
CTD	decreases(reaction)			IL10		D007052
CTD	increases(expression)			IL10		D007052
CTD	decreases(reaction)			IL1A		D007052
CTD	increases(secretion)			IL1A		D007052
CTD	increases(expression)			IL1A		D007052
CTD	affects(cotreatment)			IL1B		D007052
CTD	decreases(reaction)			IL1B		D007052
CTD	increases(metabolic processing)			IL1B		D007052
CTD	increases(secretion)			IL1B		D007052
CTD	decreases(reaction)			IL1B		D007052
CTD	increases(abundance)			IL1B		D007052
CTD	decreases(reaction)			IL1B		D007052
CTD	increases(activity)			IL1B		D007052
CTD	decreases(reaction)			IL1B		D007052
CTD	increases(secretion)			IL1B		D007052
CTD	decreases(secretion)			IL1RN		D007052
CTD	increases(expression)			IL6		D007052
CTD	decreases(expression)			INSM1		D007052
CTD	affects(expression)			ITGBL1		D007052
CTD	affects(expression)			LDHB		D007052
CTD	affects(binding)			LDLR		D007052
CTD	increases(reaction)			LDLR		D007052
CTD	increases(degradation)			LDLR		D007052
CTD	affects(expression)			LGALS1		D007052
CTD	affects(response to substance)			LTA		D007052
CTD	decreases(expression)			LTBR		D007052
CTD	decreases(expression)			LY9		D007052
CTD	increases(expression)			MAL		D007052
CTD	increases(expression)			MAPK11		D007052
CTD	increases(reaction)			MAPK11		D007052
CTD	increases(expression)			MAPK14		D007052
CTD	increases(reaction)			MAPK14		D007052
CTD	increases(expression)			MAPK14		D007052
CTD	increases(reaction)			MAPK14		D007052
CTD	increases(phosphorylation)			MAPK14		D007052
CTD	increases(activity)			MAPKAPK2		D007052
CTD	increases(phosphorylation)			MAPKAPK2		D007052
CTD	increases(expression)			MAPKAPK2		D007052
CTD	increases(reaction)			MAPKAPK2		D007052
CTD	increases(expression)			MAPKAPK3		D007052
CTD	increases(reaction)			MAPKAPK3		D007052
CTD	affects(expression)			MAPRE2		D007052
CTD	affects(cotreatment)			MCL1		D007052
CTD	decreases(expression)			MCL1		D007052
CTD	decreases(reaction)			MCL1		D007052
CTD	increases(expression)			MCL1		D007052
CTD	increases(expression)			MMP1		D007052
CTD	increases(expression)			MMP3		D007052
CTD	decreases(reaction)			MMP9		D007052
CTD	increases(activity)			MMP9		D007052
CTD	increases(expression)			MMP9		D007052
CTD	increases(expression)			MTA2		D007052
CTD	increases(expression)			MXD1		D007052
CTD	decreases(reaction)			NFKB1		D007052
CTD	increases(activity)			NFKB1		D007052
CTD	affects(binding)			NFKB1		D007052
CTD	decreases(reaction)			NFKB1		D007052
CTD	increases(activity)			NFKB1		D007052
CTD	affects(binding)			NFKB1		D007052
CTD	decreases(activity)			NFKB1		D007052
CTD	decreases(reaction)			NFKBIA		D007052
CTD	increases(degradation)			NFKBIA		D007052
CTD	decreases(reaction)			NGFR		D007052
CTD	increases(expression)			NGFR		D007052
CTD	increases(reaction)			NGFR		D007052
CTD	affects(binding)			NGFR		D007052
CTD	increases(expression)			NGFR		D007052
CTD	increases(expression)			NGFR		D007052
CTD	increases(stability)			NGFR		D007052
CTD	increases(expression)			NGFR		D007052
CTD	increases(reaction)			NGFR		D007052
CTD	affects(expression)			NOS1		D007052
CTD	affects(expression)			NQO1		D007052
CTD	decreases(expression)			P2RY2		D007052
CTD	decreases(reaction)			P2RY2		D007052
CTD	affects(binding)			PABPN1		D007052
CTD	decreases(reaction)			PABPN1		D007052
CTD	decreases(reaction)			PDGFA		D007052
CTD	increases(abundance)			PDGFA		D007052
CTD	affects(expression)			PGAM1		D007052
CTD	increases(expression)			PGAM1		D007052
CTD	affects(expression)			PLA2G2A		D007052
CTD	decreases(reaction)			PLAU		D007052
CTD	increases(expression)			PLAU		D007052
CTD	affects(expression)			PLEC		D007052
CTD	increases(expression)			PLEC		D007052
CTD	affects(expression)			PML		D007052
CTD	affects(binding)			PPARA		D007052
CTD	increases(activity)			PPARA		D007052
CTD	affects(binding)			PPARG		D007052
CTD	increases(activity)			PPARG		D007052
CTD	affects(expression)			PPIA		D007052
CTD	affects(cotreatment)			PPP1CA		D007052
CTD	increases(expression)			PPP1CA		D007052
CTD	affects(expression)			PRDX2		D007052
CTD	increases(expression)			PRDX2		D007052
CTD	affects(expression)			PRDX6		D007052
CTD	affects(expression)			PTGER3		D007052
CTD	decreases(activity)			PTGS1		D007052
CTD	decreases(activity)			PTGS1		D007052
CTD	decreases(reaction)			PTGS2		D007052
CTD	increases(activity)			PTGS2		D007052
CTD	affects(abundance)			PTGS2		D007052
CTD	affects(chemical synthesis)			PTGS2		D007052
CTD	decreases(reaction)			PTGS2		D007052
CTD	increases(metabolic processing)			PTGS2		D007052
CTD	decreases(reaction)			PTGS2		D007052
CTD	increases(expression)			PTGS2		D007052
CTD	decreases(activity)			PTGS2		D007052
CTD	decreases(activity)			PTGS2		D007052
CTD	increases(expression)			PTGS2		D007052
CTD	increases(response to substance)			PTGS2		D007052
CTD	decreases(expression)			PYY		D007052
CTD	affects(expression)			RAN		D007052
CTD	decreases(reaction)			RELA		D007052
CTD	increases(expression)			RELA		D007052
CTD	affects(binding)			RELA		D007052
CTD	decreases(reaction)			RELA		D007052
CTD	increases(activity)			RELA		D007052
CTD	decreases(reaction)			RELA		D007052
CTD	increases(activity)			RELA		D007052
CTD	affects(binding)			RELA		D007052
CTD	decreases(activity)			RELA		D007052
CTD	increases(expression)			SAT1		D007052
CTD	decreases(reaction)			SELE		D007052
CTD	increases(expression)			SELE		D007052
CTD	decreases(activity)			SLC22A1		D007052
CTD	affects(transport)			SLC22A11		D007052
CTD	decreases(reaction)			SLC22A11		D007052
CTD	decreases(activity)			SLC22A11		D007052
CTD	decreases(activity)			SLC22A6		D007052
CTD	increases(uptake)			SLC22A6		D007052
CTD	decreases(reaction)			SLC22A7		D007052
CTD	increases(transport)			SLC22A7		D007052
CTD	decreases(activity)			SLC22A7		D007052
CTD	affects(transport)			SLC22A8		D007052
CTD	decreases(reaction)			SLC22A8		D007052
CTD	decreases(activity)			SLC22A9		D007052
CTD	increases(uptake)			SLC22A9		D007052
CTD	decreases(expression)			SLC2A1		D007052
CTD	decreases(activity)			SLC5A8		D007052
CTD	affects(expression)			SOCS3		D007052
CTD	increases(expression)			SOD2		D007052
CTD	decreases(activity)			SULT1E1		D007052
CTD	increases(expression)			THBS1		D007052
CTD	affects(expression)			TMPRSS4		D007052
CTD	increases(expression)			TNC		D007052
CTD	affects(cotreatment)			TNF		D007052
CTD	decreases(reaction)			TNF		D007052
CTD	increases(expression)			TNF		D007052
CTD	increases(activity)			TNF		D007052
CTD	increases(metabolic processing)			TNF		D007052
CTD	increases(secretion)			TNF		D007052
CTD	decreases(reaction)			TNF		D007052
CTD	increases(expression)			TNF		D007052
CTD	decreases(reaction)			TNF		D007052
CTD	increases(secretion)			TNF		D007052
CTD	decreases(reaction)			TNF		D007052
CTD	increases(activity)			TNF		D007052
CTD	decreases(reaction)			TNF		D007052
CTD	increases(activity)			TNF		D007052
CTD	affects(binding)			TNF		D007052
CTD	decreases(reaction)			TNF		D007052
CTD	increases(activity)			TNF		D007052
CTD	increases(degradation)			TNF		D007052
CTD	increases(expression)			TNF		D007052
CTD	decreases(reaction)			TNF		D007052
CTD	increases(expression)			TNF		D007052
CTD	decreases(reaction)			TNF		D007052
CTD	increases(expression)			TNF		D007052
CTD	decreases(activity)			TNF		D007052
CTD	increases(activity)			TNF		D007052
CTD	increases(expression)			TNF		D007052
CTD	affects(cotreatment)			TNF		D007052
CTD	increases(reaction)			TNF		D007052
CTD	decreases(reaction)			TNFRSF21		D007052
CTD	increases(expression)			TNFRSF21		D007052
CTD	decreases(expression)			TNFRSF21		D007052
CTD	affects(expression)			TPI1		D007052
CTD	increases(expression)			TPI1		D007052
CTD	increases(glucuronidation)			UGT1A1		D007052
CTD	increases(glucuronidation)			UGT1A10		D007052
CTD	increases(glucuronidation)			UGT1A3		D007052
CTD	increases(glucuronidation)			UGT1A7		D007052
CTD	increases(glucuronidation)			UGT1A8		D007052
CTD	increases(glucuronidation)			UGT1A9		D007052
CTD	increases(glucuronidation)			UGT2B15		D007052
CTD	increases(glucuronidation)			UGT2B4		D007052
CTD	decreases(reaction)			UGT2B7		D007052
CTD	increases(chemical synthesis)			UGT2B7		D007052
CTD	increases(glucuronidation)			UGT2B7		D007052
CTD	increases(glucuronidation)			UGT2B7		D007052
CTD	increases(glucuronidation)			UGT2B7		D007052
CTD	decreases(reaction)			VCAM1		D007052
CTD	increases(expression)			VCAM1		D007052
CTD	decreases(secretion)			VEGFA		D007052
PubChem	Potency-Replicate_1	uM	68.590	ESR1	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		PTGS1	-	Target : CHEMBL221
ChEMBL	Inhibition	-		PTGS1	-	Target : CHEMBL221

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