Drug Gene Type Source ibuprofen ADAMTS8 Text_Mining(increases(expression)) CTD ibuprofen AKR1C1 Text_Mining(decreases(activity)) CTD ibuprofen AKR1C2 Text_Mining(decreases(activity)) CTD ibuprofen AKR1C3 Text_Mining(decreases(activity)) CTD ibuprofen ALB Text_Mining(affects(binding)) CTD ibuprofen ALB Text_Mining(decreases(reaction)) CTD ibuprofen ALOX12B Text_Mining(affects(expression)) CTD ibuprofen ALOXE3 Text_Mining(affects(expression)) CTD ibuprofen AMACR Text_Mining(affects(response to substance)) CTD ibuprofen AMACR Text_Mining(increases(activity)) CTD ibuprofen AMACR Text_Mining(increases(metabolic processing)) CTD ibuprofen ANXA1 Text_Mining(affects(expression)) CTD ibuprofen ANXA2 Text_Mining(affects(expression)) CTD ibuprofen ANXA3 Text_Mining(affects(expression)) CTD ibuprofen ANXA9 Text_Mining(decreases(expression)) CTD ibuprofen APP Text_Mining(affects(cleavage)) CTD ibuprofen APP Text_Mining(affects(cotreatment)) CTD ibuprofen APP Text_Mining(decreases(reaction)) CTD ibuprofen APP Text_Mining(increases(metabolic processing)) CTD ibuprofen APP Text_Mining(increases(secretion)) CTD ibuprofen APP Text_Mining(decreases(expression)) CTD ibuprofen BACE1 Text_Mining(affects(cotreatment)) CTD ibuprofen BACE1 Text_Mining(decreases(reaction)) CTD ibuprofen BACE1 Text_Mining(increases(expression)) CTD ibuprofen BACE1 Text_Mining(increases(activity)) CTD ibuprofen BACE1 Text_Mining(decreases(activity)) CTD ibuprofen BACE1 Text_Mining(decreases(expression)) CTD ibuprofen BCL2L1 Text_Mining(affects(cotreatment)) CTD ibuprofen BCL2L1 Text_Mining(decreases(expression)) CTD ibuprofen BCL2L1 Text_Mining(decreases(reaction)) CTD ibuprofen BCL2L1 Text_Mining(increases(expression)) CTD ibuprofen C3 Text_Mining(affects(expression)) CTD ibuprofen CACNA2D3 Text_Mining(affects(expression)) CTD ibuprofen CCL2 Text_Mining(decreases(reaction)) CTD ibuprofen CCL2 Text_Mining(increases(secretion)) CTD ibuprofen CCL2 Text_Mining(increases(expression)) CTD ibuprofen CCL3 Text_Mining(decreases(reaction)) CTD ibuprofen CCL3 Text_Mining(increases(expression)) CTD ibuprofen CCND1 Text_Mining(decreases(reaction)) CTD ibuprofen CCND1 Text_Mining(increases(expression)) CTD ibuprofen CD36 Text_Mining(increases(expression)) CTD ibuprofen CDH3 Text_Mining(affects(expression)) CTD ibuprofen CDSN Text_Mining(affects(expression)) CTD ibuprofen CEACAM1 Text_Mining(affects(expression)) CTD ibuprofen CHUK Text_Mining(decreases(reaction)) CTD ibuprofen CHUK Text_Mining(increases(activity)) CTD ibuprofen CHUK Text_Mining(decreases(activity)) CTD ibuprofen CLU Text_Mining(affects(expression)) CTD ibuprofen CNR2 Text_Mining(affects(binding)) CTD ibuprofen CNR2 Text_Mining(decreases(reaction)) CTD ibuprofen COL11A1 Text_Mining(affects(expression)) CTD ibuprofen CX3CL1 Text_Mining(affects(expression)) CTD ibuprofen CXCL10 Text_Mining(decreases(reaction)) CTD ibuprofen CXCL10 Text_Mining(increases(expression)) CTD ibuprofen CYP19A1 Text_Mining(decreases(activity)) CTD ibuprofen CYP19A1 Text_Mining(decreases(expression)) CTD ibuprofen CYP2C8 Text_Mining(affects(metabolic processing)) CTD ibuprofen CYP2C8 Text_Mining(decreases(metabolic processing)) CTD ibuprofen CYP2C8 Text_Mining(increases(metabolic processing)) CTD ibuprofen CYP2C9 Text_Mining(decreases(metabolic processing)) CTD ibuprofen CYP2C9 Text_Mining(affects(binding)) CTD ibuprofen CYP2C9 Text_Mining(affects(metabolic processing)) CTD ibuprofen CYP2C9 Text_Mining(increases(metabolic processing)) CTD ibuprofen CYP2C9 Text_Mining(decreases(reaction)) CTD ibuprofen DDX1 Text_Mining(affects(expression)) CTD ibuprofen DEFB4A Text_Mining(affects(expression)) CTD ibuprofen DSC1 Text_Mining(affects(expression)) CTD ibuprofen EGF Text_Mining(decreases(reaction)) CTD ibuprofen EGF Text_Mining(increases(activity)) CTD ibuprofen EGF Text_Mining(increases(expression)) CTD ibuprofen EIF4E Text_Mining(increases(phosphorylation)) CTD ibuprofen EIF4E Text_Mining(increases(reaction)) CTD ibuprofen ELAVL1 Text_Mining(increases(expression)) CTD ibuprofen ELAVL1 Text_Mining(increases(reaction)) CTD ibuprofen ELAVL1 Text_Mining(affects(binding)) CTD ibuprofen ENO1 Text_Mining(affects(expression)) CTD ibuprofen EPAS1 Text_Mining(decreases(expression)) CTD ibuprofen EPHB6 Text_Mining(affects(expression)) CTD ibuprofen ERBB4 Text_Mining(affects(cleavage)) CTD ibuprofen F3 Text_Mining(increases(expression)) CTD ibuprofen FABP4 Text_Mining(decreases(expression)) CTD ibuprofen FASN Text_Mining(affects(expression)) CTD ibuprofen FASN Text_Mining(decreases(expression)) CTD ibuprofen FOSB Text_Mining(increases(expression)) CTD ibuprofen FRZB Text_Mining(affects(expression)) CTD ibuprofen GCLC Text_Mining(increases(expression)) CTD ibuprofen GCLM Text_Mining(increases(expression)) CTD ibuprofen GDF15 Text_Mining(decreases(reaction)) CTD ibuprofen GDF15 Text_Mining(increases(expression)) CTD ibuprofen GDF15 Text_Mining(increases(reaction)) CTD ibuprofen HIF1A Text_Mining(decreases(expression)) CTD ibuprofen HPGD Text_Mining(affects(expression)) CTD ibuprofen HPGD Text_Mining(increases(activity)) CTD ibuprofen HPGD Text_Mining(increases(expression)) CTD ibuprofen HSF1 Text_Mining(increases(activity)) CTD ibuprofen HSPA1A Text_Mining(affects(localization)) CTD ibuprofen HSPA1A Text_Mining(increases(expression)) CTD ibuprofen HSPA7 Text_Mining(increases(expression)) CTD ibuprofen HSPA8 Text_Mining(affects(localization)) CTD ibuprofen ICAM1 Text_Mining(decreases(reaction)) CTD ibuprofen ICAM1 Text_Mining(increases(expression)) CTD ibuprofen ICAM1 Text_Mining(decreases(expression)) CTD ibuprofen IFNG Text_Mining(affects(cotreatment)) CTD ibuprofen IFNG Text_Mining(decreases(reaction)) CTD ibuprofen IFNG Text_Mining(increases(expression)) CTD ibuprofen IFNG Text_Mining(increases(metabolic processing)) CTD ibuprofen IFNG Text_Mining(increases(secretion)) CTD ibuprofen IFNG Text_Mining(increases(activity)) CTD ibuprofen IGHG3 Text_Mining(affects(expression)) CTD ibuprofen IGKC Text_Mining(affects(expression)) CTD ibuprofen IGKV1-5 Text_Mining(affects(expression)) CTD ibuprofen IGLC1 Text_Mining(affects(expression)) CTD ibuprofen IGLJ3 Text_Mining(affects(expression)) CTD ibuprofen IL10 Text_Mining(decreases(reaction)) CTD ibuprofen IL10 Text_Mining(increases(expression)) CTD ibuprofen IL1A Text_Mining(decreases(reaction)) CTD ibuprofen IL1A Text_Mining(increases(secretion)) CTD ibuprofen IL1A Text_Mining(increases(expression)) CTD ibuprofen IL1B Text_Mining(affects(cotreatment)) CTD ibuprofen IL1B Text_Mining(decreases(reaction)) CTD ibuprofen IL1B Text_Mining(increases(metabolic processing)) CTD ibuprofen IL1B Text_Mining(increases(secretion)) CTD ibuprofen IL1B Text_Mining(increases(abundance)) CTD ibuprofen IL1B Text_Mining(increases(activity)) CTD ibuprofen IL1RN Text_Mining(decreases(secretion)) CTD ibuprofen IL6 Text_Mining(increases(expression)) CTD ibuprofen INSM1 Text_Mining(decreases(expression)) CTD ibuprofen ITGBL1 Text_Mining(affects(expression)) CTD ibuprofen LDHB Text_Mining(affects(expression)) CTD ibuprofen LDLR Text_Mining(affects(binding)) CTD ibuprofen LDLR Text_Mining(increases(reaction)) CTD ibuprofen LDLR Text_Mining(increases(degradation)) CTD ibuprofen LGALS1 Text_Mining(affects(expression)) CTD ibuprofen LTA Text_Mining(affects(response to substance)) CTD ibuprofen LTBR Text_Mining(decreases(expression)) CTD ibuprofen LY9 Text_Mining(decreases(expression)) CTD ibuprofen MAL Text_Mining(increases(expression)) CTD ibuprofen MAPK11 Text_Mining(increases(expression)) CTD ibuprofen MAPK11 Text_Mining(increases(reaction)) CTD ibuprofen MAPK14 Text_Mining(increases(expression)) CTD ibuprofen MAPK14 Text_Mining(increases(reaction)) CTD ibuprofen MAPK14 Text_Mining(increases(phosphorylation)) CTD ibuprofen MAPKAPK2 Text_Mining(increases(activity)) CTD ibuprofen MAPKAPK2 Text_Mining(increases(phosphorylation)) CTD ibuprofen MAPKAPK2 Text_Mining(increases(expression)) CTD ibuprofen MAPKAPK2 Text_Mining(increases(reaction)) CTD ibuprofen MAPKAPK3 Text_Mining(increases(expression)) CTD ibuprofen MAPKAPK3 Text_Mining(increases(reaction)) CTD ibuprofen MAPRE2 Text_Mining(affects(expression)) CTD ibuprofen MCL1 Text_Mining(affects(cotreatment)) CTD ibuprofen MCL1 Text_Mining(decreases(expression)) CTD ibuprofen MCL1 Text_Mining(decreases(reaction)) CTD ibuprofen MCL1 Text_Mining(increases(expression)) CTD ibuprofen MMP1 Text_Mining(increases(expression)) CTD ibuprofen MMP3 Text_Mining(increases(expression)) CTD ibuprofen MMP9 Text_Mining(decreases(reaction)) CTD ibuprofen MMP9 Text_Mining(increases(activity)) CTD ibuprofen MMP9 Text_Mining(increases(expression)) CTD ibuprofen MTA2 Text_Mining(increases(expression)) CTD ibuprofen MXD1 Text_Mining(increases(expression)) CTD ibuprofen NFKB1 Text_Mining(decreases(reaction)) CTD ibuprofen NFKB1 Text_Mining(increases(activity)) CTD ibuprofen NFKB1 Text_Mining(affects(binding)) CTD ibuprofen NFKB1 Text_Mining(decreases(activity)) CTD ibuprofen NFKBIA Text_Mining(decreases(reaction)) CTD ibuprofen NFKBIA Text_Mining(increases(degradation)) CTD ibuprofen NGFR Text_Mining(decreases(reaction)) CTD ibuprofen NGFR Text_Mining(increases(expression)) CTD ibuprofen NGFR Text_Mining(increases(reaction)) CTD ibuprofen NGFR Text_Mining(affects(binding)) CTD ibuprofen NGFR Text_Mining(increases(stability)) CTD ibuprofen NOS1 Text_Mining(affects(expression)) CTD ibuprofen NQO1 Text_Mining(affects(expression)) CTD ibuprofen P2RY2 Text_Mining(decreases(expression)) CTD ibuprofen P2RY2 Text_Mining(decreases(reaction)) CTD ibuprofen PABPN1 Text_Mining(affects(binding)) CTD ibuprofen PABPN1 Text_Mining(decreases(reaction)) CTD ibuprofen PDGFA Text_Mining(decreases(reaction)) CTD ibuprofen PDGFA Text_Mining(increases(abundance)) CTD ibuprofen PGAM1 Text_Mining(affects(expression)) CTD ibuprofen PGAM1 Text_Mining(increases(expression)) CTD ibuprofen PLA2G2A Text_Mining(affects(expression)) CTD ibuprofen PLAU Text_Mining(decreases(reaction)) CTD ibuprofen PLAU Text_Mining(increases(expression)) CTD ibuprofen PLEC Text_Mining(affects(expression)) CTD ibuprofen PLEC Text_Mining(increases(expression)) CTD ibuprofen PML Text_Mining(affects(expression)) CTD ibuprofen PPARA Text_Mining(affects(binding)) CTD ibuprofen PPARA Text_Mining(increases(activity)) CTD ibuprofen PPARG Text_Mining(affects(binding)) CTD ibuprofen PPARG Text_Mining(increases(activity)) CTD ibuprofen PPIA Text_Mining(affects(expression)) CTD ibuprofen PPP1CA Text_Mining(affects(cotreatment)) CTD ibuprofen PPP1CA Text_Mining(increases(expression)) CTD ibuprofen PRDX2 Text_Mining(affects(expression)) CTD ibuprofen PRDX2 Text_Mining(increases(expression)) CTD ibuprofen PRDX6 Text_Mining(affects(expression)) CTD ibuprofen PTGER3 Text_Mining(affects(expression)) CTD ibuprofen PTGS1 Text_Mining(decreases(activity)) CTD ibuprofen PTGS2 Text_Mining(decreases(reaction)) CTD ibuprofen PTGS2 Text_Mining(increases(activity)) CTD ibuprofen PTGS2 Text_Mining(affects(abundance)) CTD ibuprofen PTGS2 Text_Mining(affects(chemical synthesis)) CTD ibuprofen PTGS2 Text_Mining(increases(metabolic processing)) CTD ibuprofen PTGS2 Text_Mining(increases(expression)) CTD ibuprofen PTGS2 Text_Mining(decreases(activity)) CTD ibuprofen PTGS2 Text_Mining(increases(response to substance)) CTD ibuprofen PYY Text_Mining(decreases(expression)) CTD ibuprofen RAN Text_Mining(affects(expression)) CTD ibuprofen RELA Text_Mining(decreases(reaction)) CTD ibuprofen RELA Text_Mining(increases(expression)) CTD ibuprofen RELA Text_Mining(affects(binding)) CTD ibuprofen RELA Text_Mining(increases(activity)) CTD ibuprofen RELA Text_Mining(decreases(activity)) CTD ibuprofen SAT1 Text_Mining(increases(expression)) CTD ibuprofen SELE Text_Mining(decreases(reaction)) CTD ibuprofen SELE Text_Mining(increases(expression)) CTD ibuprofen SLC22A1 Text_Mining(decreases(activity)) CTD ibuprofen SLC22A11 Text_Mining(affects(transport)) CTD ibuprofen SLC22A11 Text_Mining(decreases(reaction)) CTD ibuprofen SLC22A11 Text_Mining(decreases(activity)) CTD ibuprofen SLC22A6 Text_Mining(decreases(activity)) CTD ibuprofen SLC22A6 Text_Mining(increases(uptake)) CTD ibuprofen SLC22A7 Text_Mining(decreases(reaction)) CTD ibuprofen SLC22A7 Text_Mining(increases(transport)) CTD ibuprofen SLC22A7 Text_Mining(decreases(activity)) CTD ibuprofen SLC22A8 Text_Mining(affects(transport)) CTD ibuprofen SLC22A8 Text_Mining(decreases(reaction)) CTD ibuprofen SLC22A9 Text_Mining(decreases(activity)) CTD ibuprofen SLC22A9 Text_Mining(increases(uptake)) CTD ibuprofen SLC2A1 Text_Mining(decreases(expression)) CTD ibuprofen SLC5A8 Text_Mining(decreases(activity)) CTD ibuprofen SOCS3 Text_Mining(affects(expression)) CTD ibuprofen SOD2 Text_Mining(increases(expression)) CTD ibuprofen SULT1E1 Text_Mining(decreases(activity)) CTD ibuprofen THBS1 Text_Mining(increases(expression)) CTD ibuprofen TMPRSS4 Text_Mining(affects(expression)) CTD ibuprofen TNC Text_Mining(increases(expression)) CTD ibuprofen TNF Text_Mining(affects(cotreatment)) CTD ibuprofen TNF Text_Mining(decreases(reaction)) CTD ibuprofen TNF Text_Mining(increases(expression)) CTD ibuprofen TNF Text_Mining(increases(activity)) CTD ibuprofen TNF Text_Mining(increases(metabolic processing)) CTD ibuprofen TNF Text_Mining(increases(secretion)) CTD ibuprofen TNF Text_Mining(affects(binding)) CTD ibuprofen TNF Text_Mining(increases(degradation)) CTD ibuprofen TNF Text_Mining(decreases(activity)) CTD ibuprofen TNF Text_Mining(increases(reaction)) CTD ibuprofen TNFRSF21 Text_Mining(decreases(reaction)) CTD ibuprofen TNFRSF21 Text_Mining(increases(expression)) CTD ibuprofen TNFRSF21 Text_Mining(decreases(expression)) CTD ibuprofen TPI1 Text_Mining(affects(expression)) CTD ibuprofen TPI1 Text_Mining(increases(expression)) CTD ibuprofen UGT1A1 Text_Mining(increases(glucuronidation)) CTD ibuprofen UGT1A10 Text_Mining(increases(glucuronidation)) CTD ibuprofen UGT1A3 Text_Mining(increases(glucuronidation)) CTD ibuprofen UGT1A7 Text_Mining(increases(glucuronidation)) CTD ibuprofen UGT1A8 Text_Mining(increases(glucuronidation)) CTD ibuprofen UGT1A9 Text_Mining(increases(glucuronidation)) CTD ibuprofen UGT2B15 Text_Mining(increases(glucuronidation)) CTD ibuprofen UGT2B4 Text_Mining(increases(glucuronidation)) CTD ibuprofen UGT2B7 Text_Mining(decreases(reaction)) CTD ibuprofen UGT2B7 Text_Mining(increases(chemical synthesis)) CTD ibuprofen UGT2B7 Text_Mining(increases(glucuronidation)) CTD ibuprofen VCAM1 Text_Mining(decreases(reaction)) CTD ibuprofen VCAM1 Text_Mining(increases(expression)) CTD ibuprofen VEGFA Text_Mining(decreases(secretion)) CTD ibuprofen CYP1A2 Inhibition=None(Unspecified) D4 ChEMBL ibuprofen CYP2C19 Inhibition=None(Unspecified) D4 ChEMBL ibuprofen CYP2C9 Inhibition=None(Unspecified) D4 ChEMBL ibuprofen CYP2D6 Inhibition=None(Unspecified) D4 ChEMBL ibuprofen CYP3A4 Inhibition=None(Unspecified) D4 ChEMBL ibuprofen ESR1 Potency-Replicate_1=68.5896(uM) D4 PubChem ibuprofen PTGS1 Inhibition=None(Unspecified) D4 ChEMBL