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Gene Set: D4 : CTD - Flurbiprofen

Collection D4 : CTD
Chemical Name Flurbiprofen ( From PubChem : FLURBIPROFEN )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
ApprovedNotNotApprovedNotNotNotNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
244.261 g/mol 1 2 3.6808 True
Structure
InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)/t10-/m1/s1
InChIKey SYTBZMRGLBWNTM-SNVBAGLBSA-N
Links

Gene (45 / 135)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
CTDdecreases(activity)AKR1C1
D005480
CTDdecreases(activity)AKR1C2
D005480
CTDdecreases(activity)AKR1C3
D005480
CTDdecreases(activity)AKR1C3
D005480
CTDincreases(chemical synthesis)AKR1C3
D005480
CTDincreases(metabolic processing)AKR1C3
D005480
CTDaffects(binding)ALB
D005480
CTDdecreases(reaction)APP
D005480
CTDdecreases(secretion)APP
D005480
CTDaffects(cotreatment)APP
D005480
CTDincreases(secretion)APP
D005480
CTDdecreases(secretion)APP
D005480
CTDincreases(reaction)APP
D005480
CTDdecreases(expression)CCNB1
D005480
CTDdecreases(reaction)CYP2C9
D005480
CTDincreases(hydroxylation)CYP2C9
D005480
CTDaffects(hydroxylation)CYP2C9
D005480
CTDdecreases(reaction)CYP2C9
D005480
CTDincreases(reaction)CYP2C9
D005480
CTDaffects(hydrolysis)CYP2C9
D005480
CTDaffects(metabolic processing)CYP2C9
D005480
CTDincreases(hydroxylation)CYP2C9
D005480
CTDincreases(hydrolysis)CYP2C9
D005480
CTDincreases(hydroxylation)CYP2C9
D005480
CTDincreases(metabolic processing)CYP2C9
D005480
CTDincreases(reaction)CYP2C9
D005480
CTDaffects(metabolic processing)CYP2C9
D005480
CTDaffects(reaction)CYP2C9
D005480
CTDaffects(binding)CYP2C9
D005480
CTDincreases(phosphorylation)EIF4E
D005480
CTDincreases(reaction)EIF4E
D005480
CTDincreases(expression)ELAVL1
D005480
CTDincreases(reaction)ELAVL1
D005480
CTDaffects(binding)ELAVL1
D005480
CTDdecreases(reaction)FOS
D005480
CTDincreases(expression)FOS
D005480
CTDdecreases(reaction)GDF15
D005480
CTDincreases(expression)GDF15
D005480
CTDincreases(reaction)GDF15
D005480
CTDdecreases(degradation)HPGD
D005480
CTDincreases(activity)HPGD
D005480
CTDincreases(expression)HPGD
D005480
CTDdecreases(expression)HPGD
D005480
CTDaffects(cotreatment)IFNG
D005480
CTDdecreases(reaction)IFNG
D005480
CTDincreases(secretion)IFNG
D005480
CTDdecreases(reaction)IL1B
D005480
CTDincreases(expression)IL1B
D005480
CTDincreases(chemical synthesis)IL1B
D005480
CTDincreases(expression)IL1B
D005480
CTDincreases(reaction)IL1B
D005480
CTDdecreases(activity)MAPK1
D005480
CTDdecreases(phosphorylation)MAPK1
D005480
CTDincreases(expression)MAPK11
D005480
CTDincreases(reaction)MAPK11
D005480
CTDincreases(expression)MAPK14
D005480
CTDincreases(reaction)MAPK14
D005480
CTDincreases(expression)MAPK14
D005480
CTDincreases(reaction)MAPK14
D005480
CTDincreases(phosphorylation)MAPK14
D005480
CTDdecreases(activity)MAPK3
D005480
CTDdecreases(phosphorylation)MAPK3
D005480
CTDincreases(activity)MAPKAPK2
D005480
CTDincreases(phosphorylation)MAPKAPK2
D005480
CTDincreases(expression)MAPKAPK2
D005480
CTDincreases(reaction)MAPKAPK2
D005480
CTDincreases(expression)MAPKAPK3
D005480
CTDincreases(reaction)MAPKAPK3
D005480
CTDdecreases(expression)MMP9
D005480
CTDincreases(expression)MMP9
D005480
CTDdecreases(degradation)MMP9
D005480
CTDdecreases(reaction)NGFR
D005480
CTDincreases(expression)NGFR
D005480
CTDincreases(reaction)NGFR
D005480
CTDaffects(binding)NGFR
D005480
CTDincreases(expression)NGFR
D005480
CTDincreases(expression)NGFR
D005480
CTDincreases(stability)NGFR
D005480
CTDincreases(expression)NGFR
D005480
CTDincreases(reaction)NGFR
D005480
CTDincreases(activity)NQO1
D005480
CTDdecreases(reaction)PLA2G4A
D005480
CTDincreases(expression)PLA2G4A
D005480
CTDdecreases(activity)PTGS1
D005480
CTDdecreases(reaction)PTGS2
D005480
CTDincreases(expression)PTGS2
D005480
CTDdecreases(reaction)PTGS2
D005480
CTDincreases(expression)PTGS2
D005480
CTDdecreases(reaction)PTGS2
D005480
CTDincreases(expression)PTGS2
D005480
CTDdecreases(reaction)PTGS2
D005480
CTDincreases(expression)PTGS2
D005480
CTDincreases(chemical synthesis)PTGS2
D005480
CTDdecreases(reaction)PTGS2
D005480
CTDincreases(chemical synthesis)PTGS2
D005480
CTDincreases(expression)PTGS2
D005480
CTDincreases(expression)PTGS2
D005480
CTDincreases(reaction)PTGS2
D005480
CTDdecreases(activity)PTGS2
D005480
CTDdecreases(activity)PTGS2
D005480
CTDincreases(activity)PTGS2
D005480
CTDincreases(expression)PTGS2
D005480
CTDincreases(expression)PTGS2
D005480
CTDaffects(binding)RXRA
D005480
CTDdecreases(reaction)RXRA
D005480
CTDdecreases(secretion)RXRA
D005480
CTDincreases(reaction)RXRA
D005480
CTDdecreases(expression)SELL
D005480
CTDincreases(expression)TIMP1
D005480
CTDdecreases(expression)TIMP1
D005480
CTDdecreases(degradation)TIMP1
D005480
CTDaffects(cotreatment)TNF
D005480
CTDdecreases(reaction)TNF
D005480
CTDincreases(secretion)TNF
D005480
CTDincreases(abundance)TP53
D005480
CTDincreases(phosphorylation)TP53
D005480
CTDincreases(expression)TP53
D005480
CTDdecreases(response to substance)TP53
D005480
CTDincreases(response to substance)TP53
D005480
CTDincreases(glucuronidation)UGT1A1
D005480
CTDincreases(glucuronidation)UGT1A10
D005480
CTDincreases(glucuronidation)UGT1A3
D005480
CTDincreases(glucuronidation)UGT1A4
D005480
CTDincreases(glucuronidation)UGT1A6
D005480
CTDincreases(glucuronidation)UGT1A7
D005480
CTDincreases(glucuronidation)UGT1A8
D005480
CTDincreases(glucuronidation)UGT1A9
D005480
CTDincreases(glucuronidation)UGT2B4
D005480
CTDincreases(glucuronidation)UGT2B7
D005480
PubChem Potency-Replicate_1uM4.522ESR1-GI(Protien) :
PubChem Ratio Potency (uM)uMPPARG-GI(Protien) :
PubChem NoneuMPPARG-GI(Protien) :
PubChem NoneuMPRKACB-GI(Protien) :
PubChem NoneuMPRKAR2B-GI(Protien) :
ChEMBLInhibition-PTGS2
-Target : CHEMBL230
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