Tan Lab | DSigDB

Gene Set: D4 : CTD - Desipramine

Collection

D4 : CTD

Chemical Name

Desipramine ( From PubChem : DESIPRAMINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
266.381 g/mol	1	1	3.9887	True

Structure

InChI

InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3

InChIKey

HCYAFALTSJYZDH-UHFFFAOYSA-N

Links

Gene (26 / 56)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ALPP		D003891
CTD	increases(expression)			ALPP		D003891
CTD	increases(activity)			CASP3		D003891
CTD	increases(reaction)			CASP3		D003891
CTD	increases(activity)			CASP3		D003891
CTD	decreases(reaction)			CCL5		D003891
CTD	increases(expression)			CCL5		D003891
CTD	decreases(activity)			CYP2A6		D003891
CTD	decreases(activity)			CYP2C19		D003891
CTD	decreases(activity)			CYP2C9		D003891
CTD	affects(metabolic processing)			CYP2D6		D003891
CTD	decreases(activity)			CYP2E1		D003891
CTD	increases(response to substance)			CYP3A4		D003891
CTD	decreases(activity)			CYP3A4		D003891
CTD	decreases(expression)			HTR1A		D003891
CTD	decreases(reaction)			HTR1A		D003891
CTD	decreases(expression)			IFNA1		D003891
CTD	decreases(reaction)			IFNA1		D003891
CTD	decreases(activity)			KCNH2		D003891
CTD	increases(activity)			MAPK1		D003891
CTD	increases(activity)			MAPK14		D003891
CTD	increases(activity)			MAPK3		D003891
CTD	increases(phosphorylation)			MAPK8		D003891
CTD	increases(reaction)			MAPK8		D003891
CTD	increases(activity)			MAPK8		D003891
CTD	affects(response to substance)			NFE2L2		D003891
CTD	decreases(expression)			NR3C1		D003891
CTD	decreases(reaction)			NR3C1		D003891
CTD	decreases(reaction)			SLC22A2		D003891
CTD	increases(uptake)			SLC22A2		D003891
CTD	decreases(reaction)			SLC6A2		D003891
CTD	increases(activity)			SLC6A2		D003891
CTD	increases(reaction)			SLC6A2		D003891
CTD	decreases(activity)			SMPD1		D003891
CTD	decreases(reaction)			TAAR1		D003891
CTD	increases(activity)			TAAR1		D003891
CTD	increases(reaction)			TAAR1		D003891
CTD	decreases(reaction)			TNF		D003891
CTD	increases(expression)			TNF		D003891
CTD	decreases(activity)			TNF		D003891
PubChem	Potency	uM	21.331	ARSA	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	3.981	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	25.119	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	19.953	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	12.589	THPO	-	GI(Protien) :
ChEMBL	Potency	nM	3981.100	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	3981.070	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	25118.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	25118.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	19952.600	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	19952.600	CYP3A4	-	Target : CHEMBL340
ChEMBL	Activity	-		SLC6A2	-	Target : CHEMBL222
ChEMBL	Potency	nM	12589.300	THPO	-	Target : CHEMBL1293256

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