Tan Lab | DSigDB

Gene Set: D4 : CTD - Clozapine

Collection

D4 : CTD

Chemical Name

Clozapine ( From PubChem : CLOZAPINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
326.823 g/mol	1	4	1.4793	True

Structure

InChI

InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3

InChIKey

ZUXABONWMNSFBN-UHFFFAOYSA-N

Links

Gene (125 / 264)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB1		D003024
CTD	decreases(activity)			ABCB11		D003024
CTD	increases(expression)			ABCG1		D003024
CTD	decreases(reaction)			ABCG2		D003024
CTD	increases(transport)			ABCG2		D003024
CTD	increases(expression)			ABLIM2		D003024
CTD	increases(expression)			ACAT2		D003024
CTD	decreases(expression)			ADIPOQ		D003024
CTD	decreases(reaction)			AGT		D003024
CTD	increases(reaction)			AGT		D003024
CTD	increases(secretion)			AGT		D003024
CTD	increases(expression)			AKT1		D003024
CTD	increases(phosphorylation)			AKT1		D003024
CTD	decreases(reaction)			ALPP		D003024
CTD	increases(expression)			ALPP		D003024
CTD	decreases(expression)			AP1S1		D003024
CTD	increases(expression)			ASAH1		D003024
CTD	increases(expression)			ASNS		D003024
CTD	increases(expression)			BAX		D003024
CTD	decreases(reaction)			BAX		D003024
CTD	increases(expression)			BIK		D003024
CTD	decreases(reaction)			BIK		D003024
CTD	increases(expression)			C10ORF10		D003024
CTD	increases(activity)			CASP3		D003024
CTD	increases(reaction)			CASP3		D003024
CTD	increases(activity)			CASP7		D003024
CTD	increases(reaction)			CASP7		D003024
CTD	decreases(expression)			CCL1		D003024
CTD	affects(binding)			CHRM1		D003024
CTD	affects(binding)			CHRM1		D003024
CTD	affects(response to substance)			CLOCK		D003024
CTD	increases(response to substance)			COMT		D003024
CTD	affects(response to substance)			COMT		D003024
CTD	decreases(expression)			CRH		D003024
CTD	increases(expression)			CRP		D003024
CTD	decreases(reaction)			CSF3		D003024
CTD	increases(expression)			CSF3		D003024
CTD	decreases(expression)			CXCL1		D003024
CTD	decreases(expression)			CXCL5		D003024
CTD	decreases(activity)			CYP1A2		D003024
CTD	increases(abundance)			CYP1A2		D003024
CTD	decreases(reaction)			CYP1A2		D003024
CTD	increases(activity)			CYP1A2		D003024
CTD	affects(metabolic processing)			CYP1A2		D003024
CTD	affects(response to substance)			CYP1A2		D003024
CTD	decreases(metabolic processing)			CYP1A2		D003024
CTD	decreases(response to substance)			CYP1A2		D003024
CTD	increases(metabolic processing)			CYP1A2		D003024
CTD	affects(metabolic processing)			CYP1A2		D003024
CTD	affects(response to substance)			CYP1A2		D003024
CTD	affects(cotreatment)			CYP1A2		D003024
CTD	affects(response to substance)			CYP1A2		D003024
CTD	affects(metabolic processing)			CYP1A2		D003024
CTD	increases(metabolic processing)			CYP1A2		D003024
CTD	affects(reaction)			CYP1A2		D003024
CTD	increases(reaction)			CYP1A2		D003024
CTD	affects(cotreatment)			CYP2C19		D003024
CTD	affects(response to substance)			CYP2C19		D003024
CTD	decreases(activity)			CYP2C9		D003024
CTD	increases(response to substance)			CYP2C9		D003024
CTD	affects(cotreatment)			CYP2C9		D003024
CTD	affects(response to substance)			CYP2C9		D003024
CTD	affects(cotreatment)			CYP2D6		D003024
CTD	affects(response to substance)			CYP2D6		D003024
CTD	affects(metabolic processing)			CYP2D6		D003024
CTD	increases(expression)			CYP3A4		D003024
CTD	increases(reaction)			CYP3A4		D003024
CTD	affects(cotreatment)			CYP3A4		D003024
CTD	affects(response to substance)			CYP3A4		D003024
CTD	affects(metabolic processing)			CYP3A4		D003024
CTD	decreases(reaction)			CYP3A4		D003024
CTD	increases(expression)			DHCR7		D003024
CTD	decreases(response to substance)			DISC1		D003024
CTD	affects(response to substance)			DISC1		D003024
CTD	affects(binding)			DRD1		D003024
CTD	affects(response to substance)			DRD1		D003024
CTD	affects(binding)			DRD2		D003024
CTD	affects(cotreatment)			DRD2		D003024
CTD	increases(secretion)			DRD2		D003024
CTD	affects(response to substance)			DRD2		D003024
CTD	affects(response to substance)			DRD2		D003024
CTD	increases(response to substance)			DRD2		D003024
CTD	decreases(response to substance)			DRD3		D003024
CTD	affects(response to substance)			DRD3		D003024
CTD	affects(binding)			DRD4		D003024
CTD	affects(response to substance)			DRD4		D003024
CTD	increases(response to substance)			DTNBP1		D003024
CTD	affects(response to substance)			DTNBP1		D003024
CTD	increases(expression)			FABP1		D003024
CTD	affects(cotreatment)			FASLG		D003024
CTD	increases(expression)			FASLG		D003024
CTD	increases(expression)			FASN		D003024
CTD	affects(cotreatment)			FCGR3B		D003024
CTD	decreases(expression)			FCGR3B		D003024
CTD	increases(expression)			FDPS		D003024
CTD	increases(expression)			FGFBP2		D003024
CTD	increases(expression)			FNDC4		D003024
CTD	increases(expression)			GAD1		D003024
CTD	increases(expression)			GDPD3		D003024
CTD	decreases(response to substance)			GNB3		D003024
CTD	increases(response to substance)			GNB3		D003024
CTD	affects(response to substance)			GNB3		D003024
CTD	increases(phosphorylation)			GSK3B		D003024
CTD	decreases(activity)			GSTA1		D003024
CTD	increases(glutathionylation)			GSTA1		D003024
CTD	decreases(activity)			GSTM1		D003024
CTD	increases(glutathionylation)			GSTM1		D003024
CTD	affects(binding)			GSTP1		D003024
CTD	decreases(activity)			GSTP1		D003024
CTD	affects(metabolic processing)			GSTP1		D003024
CTD	decreases(activity)			GSTP1		D003024
CTD	increases(glutathionylation)			GSTP1		D003024
CTD	increases(activity)			HMGCR		D003024
CTD	increases(abundance)			HMGCR		D003024
CTD	increases(expression)			HMGCR		D003024
CTD	increases(expression)			HMGCS1		D003024
CTD	increases(expression)			HMOX1		D003024
CTD	increases(expression)			HPN		D003024
CTD	affects(binding)			HRH1		D003024
CTD	affects(activity)			HTR1A		D003024
CTD	affects(binding)			HTR1A		D003024
CTD	affects(binding)			HTR2A		D003024
CTD	affects(binding)			HTR2A		D003024
CTD	decreases(activity)			HTR2A		D003024
CTD	affects(binding)			HTR2A		D003024
CTD	affects(binding)			HTR2A		D003024
CTD	decreases(reaction)			HTR2A		D003024
CTD	increases(response to substance)			HTR2A		D003024
CTD	affects(response to substance)			HTR2A		D003024
CTD	affects(binding)			HTR2C		D003024
CTD	affects(response to substance)			HTR2C		D003024
CTD	affects(response to substance)			HTR2C		D003024
CTD	affects(response to substance)			HTR2C		D003024
CTD	affects(response to substance)			HTR2C		D003024
CTD	affects(binding)			HTR3A		D003024
CTD	decreases(activity)			HTR3A		D003024
CTD	affects(response to substance)			HTR3A		D003024
CTD	affects(binding)			HTR6		D003024
CTD	affects(binding)			HTR7		D003024
CTD	decreases(activity)			HTR7		D003024
CTD	decreases(reaction)			HTR7		D003024
CTD	increases(abundance)			HTR7		D003024
CTD	affects(binding)			HTR7		D003024
CTD	decreases(activity)			HTR7		D003024
CTD	decreases(reaction)			HTR7		D003024
CTD	affects(expression)			IFNG		D003024
CTD	decreases(expression)			IFNG		D003024
CTD	decreases(expression)			IGF1		D003024
CTD	increases(secretion)			IL2RA		D003024
CTD	affects(expression)			IL5		D003024
CTD	increases(expression)			INHBE		D003024
CTD	affects(secretion)			INS		D003024
CTD	increases(expression)			INS		D003024
CTD	decreases(reaction)			KCNH2		D003024
CTD	increases(transport)			KCNH2		D003024
CTD	increases(expression)			KMT2A		D003024
CTD	increases(expression)			LDLR		D003024
CTD	increases(expression)			LEAP2		D003024
CTD	affects(response to substance)			LEP		D003024
CTD	increases(expression)			LSS		D003024
CTD	increases(expression)			MBP		D003024
CTD	increases(expression)			MC1R		D003024
CTD	decreases(expression)			MMP10		D003024
CTD	decreases(expression)			MMP7		D003024
CTD	affects(response to substance)			MTHFR		D003024
CTD	affects(response to substance)			NFE2L2		D003024
CTD	affects(response to substance)			NQO2		D003024
CTD	increases(expression)			NR0B2		D003024
CTD	increases(expression)			NR1I2		D003024
CTD	increases(reaction)			NR1I2		D003024
CTD	decreases(reaction)			NR1I2		D003024
CTD	increases(expression)			NRG1		D003024
CTD	increases(expression)			NUPR1		D003024
CTD	increases(expression)			OVGP1		D003024
CTD	affects(response to substance)			OXT		D003024
CTD	affects(cotreatment)			PRL		D003024
CTD	increases(secretion)			PRL		D003024
CTD	increases(secretion)			PRL		D003024
CTD	affects(cotreatment)			PRL		D003024
CTD	increases(expression)			PRL		D003024
CTD	increases(expression)			PROC		D003024
CTD	increases(expression)			SC5D		D003024
CTD	increases(expression)			SCD		D003024
CTD	increases(expression)			SERPINA3		D003024
CTD	decreases(reaction)			SLC22A2		D003024
CTD	increases(uptake)			SLC22A2		D003024
CTD	decreases(expression)			SLC2A3		D003024
CTD	affects(response to substance)			SLC6A3		D003024
CTD	decreases(response to substance)			SLC6A4		D003024
CTD	decreases(uptake)			SLC6A4		D003024
CTD	affects(response to substance)			SLC6A4		D003024
CTD	affects(response to substance)			SNAP25		D003024
CTD	decreases(expression)			SPP1		D003024
CTD	increases(expression)			SREBF1		D003024
CTD	decreases(activity)			SREBF2		D003024
CTD	decreases(reaction)			SREBF2		D003024
CTD	increases(activity)			SREBF2		D003024
CTD	increases(cleavage)			SREBF2		D003024
CTD	increases(expression)			SREBF2		D003024
CTD	decreases(expression)			TAGLN		D003024
CTD	affects(response to substance)			TNF		D003024
CTD	decreases(expression)			TNFSF15		D003024
CTD	increases(expression)			TP53		D003024
CTD	decreases(reaction)			TP53		D003024
CTD	increases(expression)			UGT1A1		D003024
CTD	increases(glucuronidation)			UGT1A4		D003024
CTD	increases(expression)			WIPI1		D003024
PubChem	AR Potency (uM)	uM	28.726	AR	-	GI(Protien) :
PubChem	Potency	uM	79.433	CBX1	-	GI(Protien) :
PubChem	None	uM		CHRM1	-	GI(Protien) :
PubChem	None	uM		CHRM4	-	GI(Protien) :
PubChem	None	uM		CHRM5	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.631	DRD1	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1A		GI(Protien) :
PubChem	None	uM		HTR1B		GI(Protien) :
PubChem	None	uM		HTR1D		GI(Protien) :
PubChem	None	uM		HTR1E		GI(Protien) :
PubChem	None	uM		HTR1F		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2A		GI(Protien) :
PubChem	None	uM		HTR2B		GI(Protien) :
PubChem	None	uM		HTR2B		GI(Protien) :
PubChem	None	uM		HTR2B		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR2C		GI(Protien) :
PubChem	None	uM		HTR5A		GI(Protien) :
PubChem	None	uM		HTR5A		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	None	uM		HTR7		GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	Potency	uM	79.433	POLI	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
PubChem	Potency	uM	16.360	TDP1	-	GI(Protien) :
PubChem	Potency	uM	18.837	TDP1	-	GI(Protien) :
PubChem	Potency	uM	23.715	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	79432.800	CBX1	-	Target : CHEMBL1741193
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	631.000	DRD1	-	Target : CHEMBL2056
ChEMBL	Activity	-		DRD2	-	Target : CHEMBL217
ChEMBL	Inhibition	-		HTR7	-	Target : CHEMBL3155

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