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Gene Set: D4 : CTD - Busulfan

Collection D4 : CTD
Chemical Name Busulfan ( From PubChem : BUSULFAN )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
ApprovedNotNotApprovedNotApprovedNotNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
246.302 g/mol 0 6 1.8806 True
Structure
InChI InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
InChIKey COVZYZSDYWQREU-UHFFFAOYSA-N
Links

Gene (42 / 97)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
CTDaffects(cotreatment)ANP32B
D002066
CTDincreases(cleavage)ANP32B
D002066
CTDincreases(response to substance)APEX1
D002066
CTDdecreases(reaction)AR
D002066
CTDincreases(activity)AR
D002066
CTDaffects(reaction)ARHGDIA
D002066
CTDincreases(activity)ARHGDIA
D002066
CTDaffects(response to substance)ARHGDIA
D002066
CTDaffects(cotreatment)ATM
D002066
CTDincreases(phosphorylation)ATM
D002066
CTDaffects(reaction)CASP3
D002066
CTDincreases(activity)CASP3
D002066
CTDincreases(activity)CASP3
D002066
CTDaffects(cotreatment)CASP3
D002066
CTDincreases(cleavage)CASP3
D002066
CTDaffects(cotreatment)CASP3
D002066
CTDincreases(activity)CASP3
D002066
CTDincreases(activity)CASP8
D002066
CTDaffects(cotreatment)CASP8
D002066
CTDincreases(activity)CASP8
D002066
CTDdecreases(reaction)CASP8
D002066
CTDaffects(cotreatment)CASP9
D002066
CTDincreases(cleavage)CASP9
D002066
CTDaffects(cotreatment)CASP9
D002066
CTDdecreases(reaction)CASP9
D002066
CTDincreases(activity)CASP9
D002066
CTDaffects(cotreatment)CDC25B
D002066
CTDincreases(phosphorylation)CDC25B
D002066
CTDincreases(expression)CDKN1A
D002066
CTDaffects(cotreatment)CDKN1A
D002066
CTDincreases(expression)CDKN1A
D002066
CTDaffects(cotreatment)CHEK1
D002066
CTDincreases(phosphorylation)CHEK1
D002066
CTDaffects(cotreatment)CHEK2
D002066
CTDincreases(phosphorylation)CHEK2
D002066
CTDaffects(abundance)GSTA1
D002066
CTDaffects(metabolic processing)GSTA1
D002066
CTDaffects(response to substance)GSTA1
D002066
CTDaffects(metabolic processing)GSTA1
D002066
CTDaffects(cotreatment)GSTA1
D002066
CTDaffects(metabolic processing)GSTA1
D002066
CTDdecreases(response to substance)GSTA1
D002066
CTDaffects(abundance)GSTM1
D002066
CTDaffects(response to substance)GSTM1
D002066
CTDaffects(cotreatment)GSTM1
D002066
CTDaffects(metabolic processing)GSTM1
D002066
CTDaffects(metabolic processing)GSTM1
D002066
CTDaffects(abundance)GSTP1
D002066
CTDaffects(metabolic processing)GSTP1
D002066
CTDaffects(cotreatment)GSTT1
D002066
CTDaffects(metabolic processing)GSTT1
D002066
CTDincreases(phosphorylation)H2AFX
D002066
CTDaffects(cotreatment)H2AFX
D002066
CTDincreases(expression)H2AFX
D002066
CTDdecreases(reaction)INHBA
D002066
CTDincreases(expression)INHBA
D002066
CTDincreases(expression)INHBA
D002066
CTDincreases(activity)MAPK1
D002066
CTDincreases(activity)MAPK3
D002066
CTDdecreases(response to substance)MGST2
D002066
CTDaffects(cotreatment)MYC
D002066
CTDdecreases(expression)MYC
D002066
CTDaffects(cotreatment)NPM1
D002066
CTDincreases(response to substance)NPM1
D002066
CTDincreases(cleavage)PARP1
D002066
CTDaffects(cotreatment)PARP1
D002066
CTDincreases(cleavage)PARP1
D002066
CTDaffects(cotreatment)PARP1
D002066
CTDincreases(cleavage)PARP1
D002066
CTDdecreases(reaction)PARP1
D002066
CTDincreases(expression)PTGS2
D002066
CTDaffects(expression)SERPINC1
D002066
CTDdecreases(reaction)SERPINE1
D002066
CTDincreases(expression)SERPINE1
D002066
CTDaffects(cotreatment)SMC1A
D002066
CTDincreases(phosphorylation)SMC1A
D002066
CTDaffects(cotreatment)SMC3
D002066
CTDincreases(phosphorylation)SMC3
D002066
CTDdecreases(reaction)TF
D002066
CTDincreases(expression)TF
D002066
CTDincreases(expression)TF
D002066
CTDincreases(expression)TF
D002066
CTDdecreases(expression)TFPI
D002066
CTDincreases(expression)TGFB1
D002066
CTDincreases(expression)THBS1
D002066
CTDincreases(expression)TNF
D002066
CTDaffects(activity)TP53
D002066
CTDaffects(phosphorylation)TP53
D002066
CTDaffects(cotreatment)XIAP
D002066
CTDdecreases(expression)XIAP
D002066
PubChem Potency-Replicate_1uM11.883ESR1-GI(Protien) :
ChEMBLInhibition-CYP1A2
-Target : CHEMBL3356
ChEMBLInhibition-CYP2C19
-Target : CHEMBL3622
ChEMBLInhibition-CYP2C9
-Target : CHEMBL3397
ChEMBLInhibition-CYP2D6
-Target : CHEMBL289
ChEMBLInhibition-CYP3A4
-Target : CHEMBL340
ChEMBLInhibition-CYP3A4
-Target : CHEMBL340
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