Tan Lab | DSigDB

Gene Set: D4 : CTD - Benzbromarone

Collection

D4 : CTD

Chemical Name

Benzbromarone ( From PubChem : BENZBROMARONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Approved	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
424.083 g/mol	1	3	5.4568	False(3/4)

Structure

InChI

InChI=1S/C17H12Br2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3

InChIKey

WHQCHUCQKNIQEC-UHFFFAOYSA-N

Links

Gene (61 / 134)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCB11		D001553
CTD	increases(transport)			ABCB11		D001553
CTD	decreases(activity)			ABCB11		D001553
CTD	affects(activity)			ABCC1		D001553
CTD	decreases(reaction)			ABCC1		D001553
CTD	increases(export)			ABCC1		D001553
CTD	decreases(reaction)			ABCC1		D001553
CTD	increases(secretion)			ABCC1		D001553
CTD	decreases(activity)			ABCC2		D001553
CTD	affects(transport)			ABCC6		D001553
CTD	decreases(reaction)			ABCC6		D001553
CTD	decreases(activity)			ABCC6		D001553
CTD	increases(expression)			ADIPOQ		D001553
CTD	decreases(activity)			AKR1C1		D001553
CTD	decreases(activity)			AKR1C2		D001553
CTD	decreases(activity)			AKR1C3		D001553
CTD	decreases(activity)			AKR1C4		D001553
CTD	decreases(reaction)			CRP		D001553
CTD	increases(expression)			CRP		D001553
CTD	decreases(expression)			CRP		D001553
CTD	affects(binding)			CYP2C19		D001553
CTD	decreases(activity)			CYP2C19		D001553
CTD	affects(binding)			CYP2C9		D001553
CTD	decreases(activity)			CYP2C9		D001553
CTD	affects(binding)			CYP2C9		D001553
CTD	decreases(activity)			CYP2C9		D001553
CTD	affects(binding)			CYP2C9		D001553
CTD	affects(metabolic processing)			CYP2C9		D001553
CTD	decreases(reaction)			CYP2C9		D001553
CTD	affects(metabolic processing)			CYP2C9		D001553
CTD	decreases(reaction)			CYP2C9		D001553
CTD	affects(hydroxylation)			CYP2C9		D001553
CTD	decreases(reaction)			CYP2C9		D001553
CTD	increases(reaction)			CYP2C9		D001553
CTD	increases(reaction)			CYP2C9		D001553
CTD	affects(metabolic processing)			CYP2C9		D001553
CTD	decreases(activity)			EYA2		D001553
CTD	decreases(activity)			EYA3		D001553
CTD	affects(cotreatment)			IL1A		D001553
CTD	increases(response to substance)			IL1A		D001553
CTD	decreases(reaction)			IL1B		D001553
CTD	increases(expression)			IL1B		D001553
CTD	affects(cotreatment)			IL6		D001553
CTD	increases(response to substance)			IL6		D001553
CTD	decreases(activity)			IYD		D001553
CTD	increases(expression)			LPL		D001553
CTD	affects(activity)			SLC22A12		D001553
CTD	decreases(reaction)			SLC22A12		D001553
CTD	increases(uptake)			SLC22A12		D001553
CTD	decreases(reaction)			SLC22A12		D001553
CTD	increases(uptake)			SLC22A12		D001553
CTD	decreases(activity)			SLC22A12		D001553
CTD	affects(response to substance)			SLC22A12		D001553
CTD	affects(transport)			SLC22A6		D001553
CTD	decreases(reaction)			SLC22A6		D001553
CTD	decreases(reaction)			SLC2A9		D001553
CTD	increases(transport)			SLC2A9		D001553
CTD	increases(expression)			TNF		D001553
CTD	affects(cotreatment)			TNF		D001553
CTD	increases(response to substance)			TNF		D001553
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	None	uM		ABHD5	-	GI(Protien) :
PubChem	None	uM		ABHD5	-	GI(Protien) :
PubChem	None	uM		ATG4B	-	GI(Protien) :
PubChem	None	uM		CRHBP	-	GI(Protien) :
PubChem	None	uM		CRHR2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	0.008	CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	0.040	CYP2C9	-	GI(Protien) :
PubChem	None	uM		CYP2C9	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.682	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	14.521	ESR1	-	GI(Protien) :
PubChem	None	uM		GFER	-	GI(Protien) :
PubChem	Potency	uM	1.836	GMNN	-	GI(Protien) :
PubChem	Potency	uM	2.986	GMNN	-	GI(Protien) :
PubChem	Potency	uM	7.308	GMNN	-	GI(Protien) :
PubChem	None	uM		HCRTR1	-	GI(Protien) :
PubChem	Potency	uM	3.981	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	17.783	HPGD	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		HSPB1	-	GI(Protien) :
PubChem	None	uM		KCNE1	-	GI(Protien) :
PubChem	None	uM		KCNJ1	-	GI(Protien) :
PubChem	None	uM		KCNJ1	-	GI(Protien) :
PubChem	None	uM		KCNQ1	-	GI(Protien) :
PubChem	None	uM		KCNQ1	-	GI(Protien) :
PubChem	None	uM		KCNQ1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	IC50	uM	4.811	NCOR2	-	GI(Protien) :
PubChem	None	uM		NCOR2		GI(Protien) :
PubChem	EC50	uM		NOD1	-	GI(Protien) :
PubChem	EC50	uM		NOD2	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	15.089	NR3C1	-	GI(Protien) :
PubChem	None	uM		PLA2G1B	-	GI(Protien) :
PubChem	None	uM		PLIN1	-	GI(Protien) :
PubChem	None	uM		PLIN5	-	GI(Protien) :
PubChem	Potency	uM	8.437	PLK1	-	GI(Protien) :
PubChem	Potency	uM	50.119	POLB	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	2.683	PPARG	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.011	PPARG	-	GI(Protien) :
PubChem	IC50	uM	4.811	PPARG	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		PPARG		GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	None	uM		S1PR1	-	GI(Protien) :
PubChem	None	uM		S1PR1	-	GI(Protien) :
PubChem	None	uM		S1PR1	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	None	uM		SLC12A5	-	GI(Protien) :
PubChem	None	uM		TNF	-	GI(Protien) :
PubChem	None	uM		TNNC1	-	GI(Protien) :
PubChem	None	uM		TNNI3	-	GI(Protien) :
PubChem	None	uM		TNNT2	-	GI(Protien) :
PubChem	None	uM		TSHR		GI(Protien) :
PubChem	None	uM		TSHR		GI(Protien) :
PubChem	Potency	uM	31.623	USP1	-	GI(Protien) :
PubChem	Potency	uM	28.184	VDR	-	GI(Protien) :
PubChem	Potency	uM	50.119	VDR	-	GI(Protien) :
ChEMBL	Inhibition	-		ABCC2	-	Target : CHEMBL5748
ChEMBL	AC50	nM	12589.200	CYP1A2	-	Target : CHEMBL3356
ChEMBL	AC50	nM	7.940	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	39.800	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	7.900	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	3981.100	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	17782.800	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	12589.300	HSD17B10	-	Target : CHEMBL4159
ChEMBL	IC50	nM	4811.000	NCOR2	-	Target : CHEMBL2096976
ChEMBL	Potency	nM	50118.700	POLB	-	Target : CHEMBL2392
ChEMBL	IC50	nM	4811.000	PPARG	-	Target : CHEMBL2096976

Download gene sets

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