Tan Lab | DSigDB

Gene Set: D4 : CTD - Azathioprine

Collection

D4 : CTD

Chemical Name

Azathioprine ( From PubChem : AZATHIOPRINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
277.263 g/mol	1	6	1.669	True

Structure

InChI

InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

InChIKey

LMEKQMALGUDUQG-UHFFFAOYSA-N

Links

Gene (55 / 105)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(response to substance)			ABCB1		D001379
CTD	decreases(reaction)			AKT1		D001379
CTD	increases(phosphorylation)			AKT1		D001379
CTD	decreases(expression)			BCL2L1		D001379
CTD	decreases(expression)			DPP4		D001379
CTD	increases(expression)			FOS		D001379
CTD	decreases(reaction)			FOXO1		D001379
CTD	increases(phosphorylation)			FOXO1		D001379
CTD	increases(expression)			GCLM		D001379
CTD	increases(expression)			GPX2		D001379
CTD	increases(expression)			GPX3		D001379
CTD	increases(expression)			GSS		D001379
CTD	affects(metabolic processing)			GSTA1		D001379
CTD	affects(response to substance)			GSTA2		D001379
CTD	affects(metabolic processing)			GSTA2		D001379
CTD	affects(response to substance)			GSTM1		D001379
CTD	affects(metabolic processing)			GSTM1		D001379
CTD	affects(response to substance)			HLA-DQA1		D001379
CTD	affects(response to substance)			HLA-DRB1		D001379
CTD	decreases(reaction)			IGF1		D001379
CTD	increases(phosphorylation)			IGF1		D001379
CTD	decreases(reaction)			IGF1R		D001379
CTD	increases(phosphorylation)			IGF1R		D001379
CTD	decreases(expression)			IGF1R		D001379
CTD	affects(binding)			IL12A		D001379
CTD	increases(expression)			IL12A		D001379
CTD	affects(binding)			IL12B		D001379
CTD	increases(expression)			IL12B		D001379
CTD	affects(cotreatment)			IL1A		D001379
CTD	increases(response to substance)			IL1A		D001379
CTD	decreases(expression)			IL4		D001379
CTD	affects(cotreatment)			IL6		D001379
CTD	increases(response to substance)			IL6		D001379
CTD	affects(response to substance)			IMPDH1		D001379
CTD	increases(expression)			IMPDH2		D001379
CTD	decreases(expression)			IRS1		D001379
CTD	increases(phosphorylation)			IRS1		D001379
CTD	affects(response to substance)			ITPA		D001379
CTD	affects(response to substance)			ITPA		D001379
CTD	increases(expression)			JUN		D001379
CTD	decreases(phosphorylation)			MAP2K1		D001379
CTD	affects(binding)			MAPK1		D001379
CTD	decreases(reaction)			MAPK1		D001379
CTD	increases(reaction)			MAPK1		D001379
CTD	increases(phosphorylation)			MAPK1		D001379
CTD	affects(binding)			MAPK3		D001379
CTD	decreases(reaction)			MAPK3		D001379
CTD	increases(reaction)			MAPK3		D001379
CTD	increases(phosphorylation)			MAPK3		D001379
CTD	increases(phosphorylation)			MTOR		D001379
CTD	affects(mutagenesis)			PTCH1		D001379
CTD	affects(binding)			RAC1		D001379
CTD	decreases(reaction)			RAC1		D001379
CTD	decreases(activity)			RAC1		D001379
CTD	affects(response to substance)			RAC1		D001379
CTD	decreases(reaction)			RPS6KB1		D001379
CTD	increases(phosphorylation)			RPS6KB1		D001379
CTD	decreases(expression)			SLC15A1		D001379
CTD	increases(expression)			SOD2		D001379
CTD	affects(binding)			STAT3		D001379
CTD	decreases(reaction)			STAT3		D001379
CTD	increases(expression)			TNF		D001379
CTD	affects(cotreatment)			TNF		D001379
CTD	increases(response to substance)			TNF		D001379
CTD	increases(expression)			TP53		D001379
CTD	increases(mutagenesis)			TP53		D001379
CTD	affects(activity)			TPMT		D001379
CTD	affects(response to substance)			TPMT		D001379
CTD	affects(response to substance)			TPMT		D001379
CTD	affects(response to substance)			TPMT		D001379
CTD	affects(response to substance)			TPMT		D001379
CTD	affects(response to substance)			TPMT		D001379
CTD	affects(metabolic processing)			TPMT		D001379
CTD	affects(binding)			TSC2		D001379
CTD	decreases(reaction)			TSC2		D001379
CTD	increases(reaction)			TSC2		D001379
CTD	increases(expression)			VAV1		D001379
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	22.553	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.140	AHR	-	GI(Protien) :
PubChem	Potency	uM	0.206	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	0.316	HBB	-	GI(Protien) :
PubChem	Potency	uM	1.585	HBB	-	GI(Protien) :
PubChem	Potency	uM	1.995	HBB	-	GI(Protien) :
PubChem	Potency	uM	2.512	HBB	-	GI(Protien) :
PubChem	Potency	uM	4.109	IDH1	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	7.522	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.412	NFE2L2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.191	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	27.306	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	37.578	NFE2L2	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
ChEMBL	Potency	nM	205.900	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1995.260	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	1584.900	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	2511.900	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	316.200	HBB	-	Target : CHEMBL4331

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