Tan Lab | DSigDB

Gene Set: D4 : CTD - Amitriptyline

Collection

D4 : CTD

Chemical Name

Amitriptyline ( From PubChem : AMITRIPTYLINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
277.403 g/mol	0	1	4.1686	True

Structure

InChI

InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3

InChIKey

KRMDCWKBEZIMAB-UHFFFAOYSA-N

Links

Gene (37 / 69)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(expression)			AP1S1		D000639
CTD	increases(expression)			ASAH1		D000639
CTD	increases(expression)			ASNS		D000639
CTD	increases(expression)			C10ORF10		D000639
CTD	decreases(expression)			CAT		D000639
CTD	increases(metabolic processing)			CYP1A2		D000639
CTD	affects(cotreatment)			CYP1A2		D000639
CTD	affects(response to substance)			CYP1A2		D000639
CTD	affects(cotreatment)			CYP2C19		D000639
CTD	affects(response to substance)			CYP2C19		D000639
CTD	affects(cotreatment)			CYP2C9		D000639
CTD	affects(response to substance)			CYP2C9		D000639
CTD	decreases(activity)			CYP2D6		D000639
CTD	increases(metabolic processing)			CYP2D6		D000639
CTD	affects(cotreatment)			CYP2D6		D000639
CTD	affects(response to substance)			CYP2D6		D000639
CTD	increases(metabolic processing)			CYP2D6		D000639
CTD	increases(metabolic processing)			CYP3A4		D000639
CTD	affects(cotreatment)			CYP3A4		D000639
CTD	affects(response to substance)			CYP3A4		D000639
CTD	increases(metabolic processing)			CYP3A5		D000639
CTD	increases(expression)			FABP1		D000639
CTD	increases(expression)			FNDC4		D000639
CTD	increases(expression)			GDPD3		D000639
CTD	decreases(activity)			GSTP1		D000639
CTD	increases(expression)			HMGCS1		D000639
CTD	increases(expression)			HPN		D000639
CTD	affects(binding)			HTR2C		D000639
CTD	increases(expression)			INHBE		D000639
CTD	decreases(reaction)			KCNH2		D000639
CTD	increases(transport)			KCNH2		D000639
CTD	increases(expression)			LSS		D000639
CTD	increases(expression)			NR0B2		D000639
CTD	increases(expression)			NUPR1		D000639
CTD	increases(expression)			PHYH		D000639
CTD	increases(expression)			SCD		D000639
CTD	increases(expression)			SERPINA3		D000639
CTD	decreases(reaction)			SLC22A2		D000639
CTD	increases(uptake)			SLC22A2		D000639
CTD	decreases(reaction)			SLC22A2		D000639
CTD	increases(uptake)			SLC22A2		D000639
CTD	decreases(reaction)			SLC22A6		D000639
CTD	increases(uptake)			SLC22A6		D000639
CTD	decreases(expression)			SLC2A3		D000639
CTD	increases(activity)			SREBF1		D000639
CTD	increases(cleavage)			SREBF1		D000639
CTD	increases(activity)			SREBF2		D000639
CTD	increases(cleavage)			SREBF2		D000639
CTD	decreases(expression)			TAGLN		D000639
CTD	decreases(expression)			TRH		D000639
CTD	decreases(reaction)			TRH		D000639
CTD	decreases(expression)			TSHB		D000639
CTD	decreases(reaction)			TSHB		D000639
CTD	increases(expression)			WIPI1		D000639
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	7.943	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	1.122	DRD1	-	GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
PubChem	None	uM		HTR6		GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	AC50	nM	7943.280	CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	7943.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1122.000	DRD1	-	Target : CHEMBL2056

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