Tan Lab | DSigDB

Gene Set: D4 : CTD - carfilzomib

Collection

D4 : CTD

Chemical Name

carfilzomib ( From PubChem : CARFILZOMIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
719.91 g/mol	4	12	4.085	False(2/4)

Structure

InChI

InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1

InChIKey

BLMPQMFVWMYDKT-NZTKNTHTSA-N

Links

Gene (27 / 35)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(activity)			MAPK8		C524865
PubChem	Ratio Potency (uM)	uM	0.034	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.106	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	0.139	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.034	CYP19A1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.060	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.174	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.188	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.601	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.188	HSPB1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.045	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.067	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	0.004	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.007	TDP1	-	GI(Protien) :
PubChem	None	uM		VDR	-	GI(Protien) :
ChEMBL	Inhibition	-		PSMA1	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMA2	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMA3	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMA4	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMA5	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMA6	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMA7	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMA8	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB1	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB10	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB11	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB2	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB3	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB4	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB5	-	Target : CHEMBL4662
ChEMBL	Inhibition	-		PSMB5	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB6	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB7	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB8	-	Target : CHEMBL2364701
ChEMBL	Inhibition	-		PSMB9	-	Target : CHEMBL2364701

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