Tan Lab | DSigDB

Gene Set: D4 : CTD - crizotinib

Collection

D4 : CTD

Chemical Name

crizotinib ( From PubChem : CRIZOTINIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
450.337 g/mol	2	6	5.9477	False(3/4)

Structure

InChI

InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

InChIKey

KTEIFNKAUNYNJU-GFCCVEGCSA-N

Links

Gene (47 / 178)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ABCB1		C551994
CTD	decreases(response to substance)			ABCB1		C551994
CTD	increases(hydrolysis)			ABCB1		C551994
CTD	increases(reaction)			ABCB1		C551994
CTD	increases(phosphorylation)			ACACA		C551994
CTD	decreases(phosphorylation)			AKT1		C551994
CTD	decreases(phosphorylation)			AKT1		C551994
CTD	decreases(reaction)			AKT1		C551994
CTD	decreases(phosphorylation)			AKT1		C551994
CTD	increases(reaction)			AKT1		C551994
CTD	decreases(response to substance)			ALK		C551994
CTD	decreases(phosphorylation)			ALK		C551994
CTD	decreases(reaction)			ALK		C551994
CTD	decreases(response to substance)			ALK		C551994
CTD	affects(binding)			ALK		C551994
CTD	decreases(activity)			ALK		C551994
CTD	decreases(reaction)			ALK		C551994
CTD	decreases(activity)			ALK		C551994
CTD	decreases(reaction)			ALK		C551994
CTD	decreases(phosphorylation)			ALK		C551994
CTD	decreases(reaction)			ALK		C551994
CTD	affects(binding)			ALK		C551994
CTD	decreases(response to substance)			ALK		C551994
CTD	increases(reaction)			ALK		C551994
CTD	decreases(response to substance)			ALK		C551994
CTD	decreases(reaction)			ALK		C551994
CTD	increases(phosphorylation)			ALK		C551994
CTD	decreases(reaction)			ALK		C551994
CTD	increases(expression)			ALK		C551994
CTD	decreases(activity)			ALK		C551994
CTD	decreases(activity)			ALK		C551994
CTD	decreases(phosphorylation)			ALK		C551994
CTD	decreases(phosphorylation)			ALK		C551994
CTD	decreases(activity)			ALK		C551994
CTD	decreases(phosphorylation)			ALK		C551994
CTD	decreases(stability)			ALK		C551994
CTD	increases(mutagenesis)			ALK		C551994
CTD	decreases(response to substance)			ALK		C551994
CTD	increases(mutagenesis)			ALK		C551994
CTD	decreases(response to substance)			ALK		C551994
CTD	increases(activity)			ALK		C551994
CTD	decreases(phosphorylation)			ALK		C551994
CTD	decreases(reaction)			ALK		C551994
CTD	increases(mutagenesis)			ALK		C551994
CTD	decreases(response to substance)			ALK		C551994
CTD	affects(reaction)			BCL2L11		C551994
CTD	increases(cleavage)			BCL2L11		C551994
CTD	affects(response to substance)			BCL2L11		C551994
CTD	increases(expression)			BCL2L11		C551994
CTD	increases(reaction)			BCL2L11		C551994
CTD	decreases(expression)			BIRC2		C551994
CTD	increases(expression)			BIRC2		C551994
CTD	increases(reaction)			BIRC2		C551994
CTD	decreases(expression)			BIRC5		C551994
CTD	increases(expression)			BIRC5		C551994
CTD	increases(reaction)			BIRC5		C551994
CTD	decreases(activity)			CACNA1C		C551994
CTD	affects(reaction)			CASP3		C551994
CTD	increases(cleavage)			CASP3		C551994
CTD	increases(activity)			CASP3		C551994
CTD	increases(reaction)			CASP3		C551994
CTD	increases(activity)			CASP7		C551994
CTD	decreases(expression)			CD44		C551994
CTD	decreases(expression)			CDA		C551994
CTD	increases(response to substance)			CDA		C551994
CTD	decreases(phosphorylation)			CRKL		C551994
CTD	increases(expression)			CRKL		C551994
CTD	increases(phosphorylation)			CRKL		C551994
CTD	increases(expression)			CYP3A4		C551994
CTD	decreases(phosphorylation)			EGF		C551994
CTD	decreases(reaction)			EGF		C551994
CTD	decreases(response to substance)			EGF		C551994
CTD	increases(reaction)			EGF		C551994
CTD	decreases(response to substance)			EGFR		C551994
CTD	decreases(response to substance)			EGFR		C551994
CTD	increases(reaction)			EGFR		C551994
CTD	decreases(response to substance)			EGFR		C551994
CTD	decreases(response to substance)			EGFR		C551994
CTD	increases(phosphorylation)			EGFR		C551994
CTD	decreases(stability)			EML4		C551994
CTD	increases(mutagenesis)			EML4		C551994
CTD	decreases(response to substance)			EML4		C551994
CTD	decreases(expression)			EPCAM		C551994
CTD	increases(expression)			FADS2		C551994
CTD	increases(expression)			FASN		C551994
CTD	decreases(activity)			FGFR1		C551994
CTD	decreases(phosphorylation)			FGFR1		C551994
CTD	decreases(reaction)			FGFR1		C551994
CTD	increases(expression)			FGFR1		C551994
CTD	decreases(secretion)			FSHB		C551994
CTD	decreases(response to substance)			HBEGF		C551994
CTD	increases(reaction)			HBEGF		C551994
CTD	decreases(reaction)			HBEGF		C551994
CTD	decreases(phosphorylation)			HBEGF		C551994
CTD	decreases(phosphorylation)			HGF		C551994
CTD	increases(expression)			HGF		C551994
CTD	increases(phosphorylation)			HGF		C551994
CTD	decreases(activity)			HGF		C551994
CTD	decreases(reaction)			HGF		C551994
CTD	increases(expression)			HMGCR		C551994
CTD	increases(expression)			HMGCS1		C551994
CTD	increases(expression)			INSIG1		C551994
CTD	decreases(activity)			KCNH2		C551994
CTD	decreases(response to substance)			KIT		C551994
CTD	decreases(response to substance)			KRAS		C551994
CTD	decreases(activity)			LCK		C551994
CTD	decreases(secretion)			LHB		C551994
CTD	decreases(reaction)			MAPK1		C551994
CTD	increases(phosphorylation)			MAPK1		C551994
CTD	decreases(phosphorylation)			MAPK1		C551994
CTD	decreases(phosphorylation)			MAPK1		C551994
CTD	increases(expression)			MAPK1		C551994
CTD	increases(phosphorylation)			MAPK1		C551994
CTD	decreases(phosphorylation)			MAPK1		C551994
CTD	decreases(reaction)			MAPK1		C551994
CTD	decreases(response to substance)			MAPK1		C551994
CTD	decreases(phosphorylation)			MAPK1		C551994
CTD	decreases(reaction)			MAPK1		C551994
CTD	decreases(phosphorylation)			MAPK1		C551994
CTD	increases(reaction)			MAPK1		C551994
CTD	decreases(reaction)			MAPK3		C551994
CTD	increases(phosphorylation)			MAPK3		C551994
CTD	decreases(phosphorylation)			MAPK3		C551994
CTD	decreases(phosphorylation)			MAPK3		C551994
CTD	increases(expression)			MAPK3		C551994
CTD	increases(phosphorylation)			MAPK3		C551994
CTD	decreases(phosphorylation)			MAPK3		C551994
CTD	decreases(reaction)			MAPK3		C551994
CTD	decreases(response to substance)			MAPK3		C551994
CTD	decreases(phosphorylation)			MAPK3		C551994
CTD	decreases(reaction)			MAPK3		C551994
CTD	decreases(phosphorylation)			MAPK3		C551994
CTD	increases(reaction)			MAPK3		C551994
CTD	decreases(response to substance)			MET		C551994
CTD	increases(mutagenesis)			MET		C551994
CTD	affects(binding)			MET		C551994
CTD	decreases(activity)			MET		C551994
CTD	decreases(reaction)			MET		C551994
CTD	decreases(activity)			MET		C551994
CTD	decreases(phosphorylation)			MET		C551994
CTD	decreases(phosphorylation)			MET		C551994
CTD	increases(expression)			MET		C551994
CTD	increases(phosphorylation)			MET		C551994
CTD	decreases(phosphorylation)			MET		C551994
CTD	decreases(phosphorylation)			MET		C551994
CTD	increases(reaction)			MET		C551994
CTD	decreases(phosphorylation)			MET		C551994
CTD	increases(reaction)			MET		C551994
CTD	increases(cleavage)			MET		C551994
CTD	increases(expression)			MET		C551994
CTD	increases(response to substance)			MET		C551994
CTD	decreases(activity)			MET		C551994
CTD	decreases(reaction)			MET		C551994
CTD	decreases(activity)			MET		C520390
CTD	decreases(reaction)			MYCN		C551994
CTD	increases(expression)			MYCN		C551994
CTD	decreases(expression)			PROM1		C551994
CTD	decreases(phosphorylation)			ROS1		C551994
CTD	decreases(phosphorylation)			RPS6		C551994
CTD	decreases(activity)			SCN5A		C551994
CTD	increases(expression)			SREBF2		C551994
CTD	decreases(phosphorylation)			STAT3		C551994
CTD	increases(expression)			STAT3		C551994
CTD	increases(phosphorylation)			STAT3		C551994
CTD	decreases(phosphorylation)			STAT3		C551994
CTD	decreases(phosphorylation)			STAT3		C551994
CTD	increases(reaction)			STAT3		C551994
CTD	decreases(response to substance)			TGFA		C551994
CTD	increases(reaction)			TGFA		C551994
CTD	decreases(reaction)			TGFA		C551994
CTD	decreases(phosphorylation)			TGFA		C551994
CTD	decreases(response to substance)			TWIST1		C551994
CTD	decreases(expression)			VIM		C551994
CTD	decreases(expression)			XIAP		C551994
CTD	increases(expression)			XIAP		C551994
CTD	increases(reaction)			XIAP		C551994
PubChem	Potency	uM	0.688	YES1		GI(Protien) :
ChEMBL	Inhibition	-		ALK	-	Target : CHEMBL4247

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