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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : CTD - (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine

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Collection	D4 : CTD
Chemical Name	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine ( From PubChem : DORSOMORPHIN )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 399.488 g/mol 0 6 4.2609 True
Structure
InChI	InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
InChIKey	XHBVYDAKJHETMP-UHFFFAOYSA-N
Links
Gene (45 / 113) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(expression) ABCB1 C516138 CTD decreases(reaction) ABCB1 C516138 CTD decreases(reaction) ACACA C516138 CTD increases(phosphorylation) ACACA C516138 CTD decreases(reaction) ACACA C516138 CTD increases(phosphorylation) ACACA C516138 CTD decreases(phosphorylation) AKT1 C516138 CTD decreases(reaction) AKT1 C516138 CTD increases(phosphorylation) AKT1 C516138 CTD decreases(reaction) ALB C516138 CTD increases(expression) ALB C516138 CTD decreases(expression) APP C516138 CTD decreases(reaction) APP C516138 CTD increases(phosphorylation) ATM C516138 CTD decreases(reaction) ATM C516138 CTD increases(expression) BAX C516138 CTD affects(localization) CAMP C516138 CTD decreases(reaction) CAMP C516138 CTD increases(cleavage) CASP3 C516138 CTD decreases(reaction) CASP3 C516138 CTD decreases(expression) CCNB1 C516138 CTD decreases(reaction) CCNB1 C516138 CTD decreases(expression) CDK1 C516138 CTD decreases(phosphorylation) CDK1 C516138 CTD decreases(reaction) CDK1 C516138 CTD increases(expression) CDKN1A C516138 CTD decreases(reaction) CDKN1A C516138 CTD increases(phosphorylation) CHEK2 C516138 CTD decreases(reaction) CHEK2 C516138 CTD increases(phosphorylation) CREB1 C516138 CTD decreases(reaction) CYBA C516138 CTD increases(expression) CYBA C516138 CTD decreases(reaction) CYP4F2 C516138 CTD increases(expression) CYP4F2 C516138 CTD decreases(reaction) FAS C516138 CTD increases(expression) FAS C516138 CTD decreases(expression) G6PC3 C516138 CTD decreases(reaction) G6PC3 C516138 CTD decreases(reaction) GCLC C516138 CTD increases(activity) GCLC C516138 CTD increases(expression) GCLC C516138 CTD decreases(reaction) GDF2 C516138 CTD increases(phosphorylation) GDF2 C516138 CTD decreases(reaction) GSK3B C516138 CTD increases(phosphorylation) GSK3B C516138 CTD decreases(activity) GSK3B C516138 CTD decreases(reaction) GSK3B C516138 CTD increases(phosphorylation) GSK3B C516138 CTD increases(phosphorylation) H2AFX C516138 CTD decreases(reaction) H2AFX C516138 CTD decreases(reaction) HMOX1 C516138 CTD increases(activity) HMOX1 C516138 CTD increases(expression) HMOX1 C516138 CTD decreases(reaction) HMOX1 C516138 CTD increases(expression) HMOX1 C516138 CTD decreases(reaction) ICAM1 C516138 CTD increases(expression) ICAM1 C516138 CTD decreases(expression) KLF2 C516138 CTD decreases(phosphorylation) MTOR C516138 CTD decreases(reaction) MTOR C516138 CTD decreases(reaction) NFE2L2 C516138 CTD increases(activity) NFE2L2 C516138 CTD increases(expression) NFE2L2 C516138 CTD affects(localization) NFE2L2 C516138 CTD decreases(reaction) NFE2L2 C516138 CTD increases(activity) NFE2L2 C516138 CTD decreases(reaction) NOS3 C516138 CTD increases(activity) NOS3 C516138 CTD decreases(reaction) NR0B2 C516138 CTD increases(expression) NR0B2 C516138 CTD increases(cleavage) PARP1 C516138 CTD decreases(reaction) PARP1 C516138 CTD decreases(expression) PCK1 C516138 CTD decreases(reaction) PCK1 C516138 CTD decreases(expression) PPARGC1A C516138 CTD decreases(reaction) PPARGC1A C516138 CTD decreases(phosphorylation) PRKAA1 C516138 CTD decreases(reaction) PRKAA1 C516138 CTD increases(phosphorylation) PRKAA1 C516138 CTD decreases(phosphorylation) PRKAA2 C516138 CTD decreases(reaction) PRKAA2 C516138 CTD increases(phosphorylation) PRKAA2 C516138 CTD decreases(phosphorylation) RPS6 C516138 CTD decreases(reaction) RPS6 C516138 CTD decreases(reaction) SELE C516138 CTD increases(expression) SELE C516138 CTD decreases(reaction) SMAD1 C516138 CTD increases(phosphorylation) SMAD1 C516138 CTD decreases(reaction) SMAD5 C516138 CTD increases(phosphorylation) SMAD5 C516138 CTD decreases(reaction) SMAD9 C516138 CTD increases(phosphorylation) SMAD9 C516138 CTD decreases(localization) SOX17 C516138 CTD decreases(reaction) SREBF1 C516138 CTD increases(expression) SREBF1 C516138 CTD decreases(expression) SREBF1 C516138 CTD decreases(reaction) SREBF1 C516138 CTD decreases(reaction) STK11 C516138 CTD increases(phosphorylation) STK11 C516138 CTD affects(localization) TP53 C516138 CTD decreases(reaction) TP53 C516138 CTD increases(phosphorylation) TP53 C516138 CTD increases(expression) TP53 C516138 CTD increases(phosphorylation) TP53 C516138 CTD decreases(reaction) TP53 C516138 CTD decreases(expression) TP53 C516138 CTD decreases(phosphorylation) TP53 C516138 CTD increases(cleavage) TP53 C516138 CTD increases(response to substance) TP53 C516138 CTD decreases(reaction) VCAM1 C516138 CTD increases(expression) VCAM1 C516138 PubChem Potency uM 0.055 YES1 GI(Protien) : PubChem Potency uM 0.196 YES1 - GI(Protien) :
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