Tan Lab | DSigDB

Gene Set: D4 : CTD - gefitinib

Collection

D4 : CTD

Chemical Name

gefitinib ( From PubChem : GEFITINIB )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
446.902 g/mol	1	6	4.2865	True

Structure

InChI

InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)

InChIKey

XGALLCVXEZPNRQ-UHFFFAOYSA-N

Links

Gene (95 / 280)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB11		C419708
CTD	decreases(reaction)			ABCG2		C419708
CTD	decreases(response to substance)			ABCG2		C419708
CTD	affects(localization)			ABCG2		C419708
CTD	decreases(activity)			ABCG2		C419708
CTD	decreases(export)			ABCG2		C419708
CTD	decreases(expression)			ADORA1		C419708
CTD	decreases(reaction)			AKT1		C419708
CTD	increases(phosphorylation)			AKT1		C419708
CTD	decreases(reaction)			AKT1		C419708
CTD	increases(phosphorylation)			AKT1		C419708
CTD	affects(response to substance)			AREG		C419708
CTD	decreases(response to substance)			AREG		C419708
CTD	decreases(reaction)			AREG		C419708
CTD	increases(expression)			AREG		C419708
CTD	affects(cotreatment)			AREG		C419708
CTD	decreases(reaction)			AREG		C419708
CTD	increases(phosphorylation)			AREG		C419708
CTD	increases(expression)			ATG5		C419708
CTD	increases(expression)			ATG7		C419708
CTD	decreases(response to substance)			AURKA		C419708
CTD	increases(degradation)			AURKA		C419708
CTD	decreases(expression)			AURKA		C419708
CTD	increases(response to substance)			AURKA		C419708
CTD	affects(response to substance)			AVEN		C419708
CTD	increases(response to substance)			BCL2L11		C419708
CTD	increases(expression)			BIRC5		C419708
CTD	decreases(reaction)			BIRC5		C419708
CTD	increases(activity)			CASP3		C419708
CTD	increases(cleavage)			CASP3		C419708
CTD	increases(expression)			CAV1		C419708
CTD	decreases(expression)			CCND1		C419708
CTD	decreases(expression)			CCND3		C419708
CTD	decreases(reaction)			CD14		C419708
CTD	increases(expression)			CD14		C419708
CTD	increases(reaction)			CD14		C419708
CTD	increases(expression)			CDKN1A		C419708
CTD	affects(cotreatment)			CDKN1B		C419708
CTD	decreases(expression)			CDKN1B		C419708
CTD	increases(reaction)			CDKN1B		C419708
CTD	decreases(expression)			CDKN1B		C419708
CTD	increases(expression)			CDKN1B		C419708
CTD	increases(expression)			CDKN2B		C419708
CTD	increases(expression)			CGRRF1		C419708
CTD	affects(response to substance)			COL4A3BP		C419708
CTD	affects(response to substance)			CORO1C		C419708
CTD	decreases(reaction)			CXCL8		C419708
CTD	increases(expression)			CXCL8		C419708
CTD	affects(localization)			CYCS		C419708
CTD	affects(metabolic processing)			CYP2D6		C419708
CTD	decreases(expression)			CYP2F1		C419708
CTD	affects(metabolic processing)			CYP3A4		C419708
CTD	affects(metabolic processing)			CYP3A5		C419708
CTD	affects(response to substance)			DUSP3		C419708
CTD	decreases(expression)			DUSP9		C419708
CTD	decreases(expression)			E2F1		C419708
CTD	decreases(expression)			E2F1		C419708
CTD	affects(localization)			EGF		C419708
CTD	decreases(reaction)			EGF		C419708
CTD	decreases(reaction)			EGF		C419708
CTD	increases(phosphorylation)			EGF		C419708
CTD	decreases(reaction)			EGF		C419708
CTD	increases(activity)			EGF		C419708
CTD	increases(phosphorylation)			EGF		C419708
CTD	decreases(reaction)			EGF		C419708
CTD	increases(phosphorylation)			EGF		C419708
CTD	decreases(reaction)			EGF		C419708
CTD	increases(phosphorylation)			EGF		C419708
CTD	decreases(reaction)			EGF		C419708
CTD	increases(phosphorylation)			EGF		C419708
CTD	decreases(reaction)			EGF		C419708
CTD	increases(activity)			EGF		C419708
CTD	increases(phosphorylation)			EGF		C419708
CTD	affects(binding)			EGF		C419708
CTD	increases(reaction)			EGF		C419708
CTD	decreases(reaction)			EGF		C419708
CTD	increases(abundance)			EGF		C419708
CTD	increases(reaction)			EGF		C419708
CTD	affects(response to substance)			EGFR		C419708
CTD	decreases(response to substance)			EGFR		C419708
CTD	increases(response to substance)			EGFR		C419708
CTD	increases(response to substance)			EGFR		C419708
CTD	affects(response to substance)			EGFR		C419708
CTD	decreases(response to substance)			EGFR		C419708
CTD	increases(response to substance)			EGFR		C419708
CTD	affects(cotreatment)			EGFR		C419708
CTD	decreases(phosphorylation)			EGFR		C419708
CTD	decreases(reaction)			EGFR		C419708
CTD	increases(activity)			EGFR		C419708
CTD	increases(phosphorylation)			EGFR		C419708
CTD	decreases(reaction)			EGFR		C419708
CTD	increases(phosphorylation)			EGFR		C419708
CTD	decreases(reaction)			EGFR		C419708
CTD	increases(activity)			EGFR		C419708
CTD	increases(phosphorylation)			EGFR		C419708
CTD	decreases(reaction)			EGFR		C419708
CTD	increases(degradation)			EGFR		C419708
CTD	increases(phosphorylation)			EGFR		C419708
CTD	decreases(reaction)			EGFR		C419708
CTD	increases(activity)			EGFR		C419708
CTD	increases(phosphorylation)			EGFR		C419708
CTD	affects(binding)			EGFR		C419708
CTD	increases(reaction)			EGFR		C419708
CTD	decreases(activity)			EGFR		C419708
CTD	affects(binding)			EGFR		C419708
CTD	increases(reaction)			EGFR		C419708
CTD	decreases(activity)			EGFR		C419708
CTD	affects(binding)			EGFR		C419708
CTD	decreases(activity)			EGFR		C419708
CTD	affects(localization)			EGFR		C419708
CTD	decreases(activity)			EGFR		C419708
CTD	decreases(export)			EGFR		C419708
CTD	decreases(expression)			EGFR		C419708
CTD	decreases(phosphorylation)			EGFR		C419708
CTD	decreases(response to substance)			EGFR		C419708
CTD	increases(activity)			EGFR		C419708
CTD	increases(expression)			EPOR		C419708
CTD	increases(expression)			EPS15		C419708
CTD	decreases(reaction)			ERBB2		C419708
CTD	increases(activity)			ERBB2		C419708
CTD	increases(phosphorylation)			ERBB2		C419708
CTD	affects(binding)			ERBB2		C419708
CTD	decreases(activity)			ERBB2		C419708
CTD	decreases(phosphorylation)			ERBB2		C419708
CTD	affects(response to substance)			ERCC1		C419708
CTD	affects(cotreatment)			ERCC1		C419708
CTD	decreases(phosphorylation)			ESR1		C419708
CTD	increases(expression)			ESR2		C419708
CTD	increases(expression)			FGF6		C419708
CTD	increases(response to substance)			FOXO3		C419708
CTD	affects(localization)			FOXO3		C419708
CTD	decreases(phosphorylation)			FOXO3		C419708
CTD	increases(expression)			GADD45A		C419708
CTD	decreases(expression)			GADD45G		C419708
CTD	increases(expression)			GARS		C419708
CTD	affects(response to substance)			GCLC		C419708
CTD	decreases(expression)			GNB2		C419708
CTD	decreases(expression)			GUCY2D		C419708
CTD	decreases(reaction)			HBEGF		C419708
CTD	increases(expression)			HBEGF		C419708
CTD	decreases(expression)			IFI6		C419708
CTD	affects(binding)			IGF1R		C419708
CTD	increases(reaction)			IGF1R		C419708
CTD	increases(phosphorylation)			IGF1R		C419708
CTD	decreases(reaction)			IGF1R		C419708
CTD	decreases(reaction)			ITGAM		C419708
CTD	increases(expression)			ITGAM		C419708
CTD	increases(reaction)			ITGAM		C419708
CTD	decreases(response to substance)			ITGB1		C419708
CTD	increases(activity)			ITGB1		C419708
CTD	affects(response to substance)			KRAS		C419708
CTD	decreases(expression)			LEPR		C419708
CTD	decreases(reaction)			MAPK1		C419708
CTD	increases(phosphorylation)			MAPK1		C419708
CTD	affects(localization)			MAPK1		C419708
CTD	decreases(reaction)			MAPK1		C419708
CTD	decreases(reaction)			MAPK1		C419708
CTD	increases(activity)			MAPK1		C419708
CTD	increases(phosphorylation)			MAPK1		C419708
CTD	decreases(reaction)			MAPK1		C419708
CTD	increases(phosphorylation)			MAPK1		C419708
CTD	decreases(reaction)			MAPK1		C419708
CTD	increases(activity)			MAPK1		C419708
CTD	affects(cotreatment)			MAPK1		C419708
CTD	decreases(reaction)			MAPK1		C419708
CTD	increases(phosphorylation)			MAPK1		C419708
CTD	affects(cotreatment)			MAPK1		C419708
CTD	decreases(phosphorylation)			MAPK1		C419708
CTD	increases(reaction)			MAPK1		C419708
CTD	decreases(expression)			MAPK1		C419708
CTD	decreases(phosphorylation)			MAPK1		C419708
CTD	increases(phosphorylation)			MAPK1		C419708
CTD	decreases(reaction)			MAPK3		C419708
CTD	increases(phosphorylation)			MAPK3		C419708
CTD	affects(localization)			MAPK3		C419708
CTD	decreases(reaction)			MAPK3		C419708
CTD	decreases(reaction)			MAPK3		C419708
CTD	increases(activity)			MAPK3		C419708
CTD	increases(phosphorylation)			MAPK3		C419708
CTD	decreases(reaction)			MAPK3		C419708
CTD	increases(phosphorylation)			MAPK3		C419708
CTD	decreases(reaction)			MAPK3		C419708
CTD	increases(activity)			MAPK3		C419708
CTD	affects(cotreatment)			MAPK3		C419708
CTD	decreases(reaction)			MAPK3		C419708
CTD	increases(phosphorylation)			MAPK3		C419708
CTD	affects(cotreatment)			MAPK3		C419708
CTD	decreases(phosphorylation)			MAPK3		C419708
CTD	increases(reaction)			MAPK3		C419708
CTD	decreases(expression)			MAPK3		C419708
CTD	decreases(phosphorylation)			MAPK3		C419708
CTD	increases(phosphorylation)			MAPK3		C419708
CTD	increases(phosphorylation)			MAPK8		C419708
CTD	decreases(expression)			MLH1		C419708
CTD	decreases(phosphorylation)			MTOR		C419708
CTD	decreases(expression)			MYC		C419708
CTD	decreases(expression)			NFKB1		C419708
CTD	decreases(response to substance)			NFKBIA		C419708
CTD	increases(degradation)			NFKBIA		C419708
CTD	decreases(expression)			NPTX2		C419708
CTD	decreases(expression)			NRL		C419708
CTD	affects(response to substance)			OSMR		C419708
CTD	affects(reaction)			PARP1		C419708
CTD	increases(cleavage)			PARP1		C419708
CTD	increases(cleavage)			PARP1		C419708
CTD	affects(response to substance)			PHLDA2		C419708
CTD	affects(response to substance)			PLBD1		C419708
CTD	affects(cotreatment)			PTGS2		C419708
CTD	decreases(expression)			PTGS2		C419708
CTD	increases(reaction)			PTGS2		C419708
CTD	decreases(expression)			PTTG1		C419708
CTD	decreases(stability)			PTTG1		C419708
CTD	decreases(response to substance)			PTTG1		C419708
CTD	increases(expression)			QSOX1		C419708
CTD	affects(response to substance)			RBM7		C419708
CTD	decreases(reaction)			RELA		C419708
CTD	increases(phosphorylation)			RELA		C419708
CTD	decreases(response to substance)			RELA		C419708
CTD	increases(expression)			RPA1		C419708
CTD	decreases(phosphorylation)			RPS6KB1		C419708
CTD	affects(response to substance)			RRM1		C419708
CTD	decreases(expression)			SFN		C419708
CTD	increases(expression)			SKI		C419708
CTD	affects(response to substance)			SNAI2		C419708
CTD	decreases(localization)			SOX17		C419708
CTD	decreases(reaction)			STAT3		C419708
CTD	increases(phosphorylation)			STAT3		C419708
CTD	decreases(reaction)			STAT3		C419708
CTD	increases(phosphorylation)			STAT3		C419708
CTD	decreases(expression)			TERT		C419708
CTD	decreases(reaction)			TGFA		C419708
CTD	increases(reaction)			TGFA		C419708
CTD	increases(response to substance)			TGFA		C419708
CTD	decreases(reaction)			TGFA		C419708
CTD	increases(secretion)			TGFA		C419708
CTD	decreases(response to substance)			TGFA		C419708
CTD	decreases(expression)			TNFRSF1B		C419708
CTD	affects(response to substance)			TP53		C419708
CTD	decreases(expression)			TP53		C419708
CTD	increases(response to substance)			TP53		C419708
CTD	decreases(expression)			TYMS		C419708
CTD	affects(cotreatment)			TYMS		C419708
CTD	affects(response to substance)			TYMS		C419708
CTD	affects(response to substance)			XRCC1		C419708
PubChem	AhR Potency (uM)	uM	7.216	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	14.960	AHR	-	GI(Protien) :
PubChem	Potency	uM	0.003	EGFR	-	GI(Protien) :
PubChem	Potency	uM	0.003	EGFR	-	GI(Protien) :
PubChem	EGFR IC50	uM	0.004	EGFR	-	GI(Protien) :
PubChem	None	uM	0.520	EGFR	-	GI(Protien) :
PubChem	None	uM	0.540	EGFR	-	GI(Protien) :
PubChem	None	uM	0.570	EGFR	-	GI(Protien) :
PubChem	None	uM	0.570	EGFR	-	GI(Protien) :
PubChem	None	uM	0.940	EGFR	-	GI(Protien) :
PubChem	None	uM	0.980	EGFR	-	GI(Protien) :
PubChem	None	uM	1.000	EGFR	-	GI(Protien) :
PubChem	None	uM	1.100	EGFR	-	GI(Protien) :
PubChem	Potency	uM	1.122	EGFR	-	GI(Protien) :
PubChem	None	uM	1.400	EGFR	-	GI(Protien) :
PubChem	None	uM	2.000	EGFR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	16.930	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	16.930	ESR1	-	GI(Protien) :
PubChem	Potency	uM	29.855	GMNN	-	GI(Protien) :
PubChem	Potency	uM	39.811	MAPT	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	4.730	NFE2L2	-	GI(Protien) :
PubChem	None	uM		PIM1	-	GI(Protien) :
PubChem	None	uM		SLK	-	GI(Protien) :
PubChem	Potency	uM	1.373	YES1		GI(Protien) :
PubChem	Potency	uM	1.729	YES1		GI(Protien) :
ChEMBL	Inhibition	-		EGFR	-	Target : CHEMBL203
ChEMBL	Inhibition	-		EGFR	-	Target : CHEMBL203
ChEMBL	Inhibition	-		EGFR	-	Target : CHEMBL203
ChEMBL	Inhibition	-		EGFR	-	Target : CHEMBL203
ChEMBL	Inhibition	-		EGFR	-	Target : CHEMBL203
ChEMBL	Potency	nM	1122.000	EGFR	-	Target : CHEMBL203
ChEMBL	Potency	nM	3.200	EGFR	-	Target : CHEMBL203
ChEMBL	Potency	nM	3.200	EGFR	-	Target : CHEMBL203
ChEMBL	Inhibition	-		ERBB2	-	Target : CHEMBL1824
ChEMBL	Potency	nM	39810.700	MAPT	-	Target : CHEMBL1293224
ChEMBL	Inhibition	-		MET	-	Target : CHEMBL3717

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