Tan Lab | DSigDB

Gene Set: D4 : CTD - helenalin

Collection

D4 : CTD

Chemical Name

helenalin ( From PubChem : HELENALIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
262.301 g/mol	1	4	1.2463	True

Structure

InChI

InChI=1S/C15H18O4/c1-7-6-10-12(8(2)14(18)19-10)13(17)15(3)9(7)4-5-11(15)16/h4-5,7,9-10,12-13,17H,2,6H2,1,3H3/t7-,9+,10-,12-,13+,15+/m1/s1

InChIKey

ZVLOPMNVFLSSAA-XEPQRQSNSA-N

Links

Gene (53 / 111)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ATF4		C001329
CTD	decreases(reaction)			CASP3		C001329
CTD	increases(activity)			CASP3		C001329
CTD	decreases(reaction)			CASP8		C001329
CTD	increases(activity)			CASP8		C001329
CTD	decreases(reaction)			CD40		C001329
CTD	increases(expression)			CD40		C001329
CTD	decreases(reaction)			CD80		C001329
CTD	increases(expression)			CD80		C001329
CTD	decreases(reaction)			CD83		C001329
CTD	increases(expression)			CD83		C001329
CTD	decreases(reaction)			CD86		C001329
CTD	increases(expression)			CD86		C001329
CTD	increases(expression)			DDIT3		C001329
CTD	increases(expression)			DDIT4		C001329
CTD	decreases(reaction)			ICAM1		C001329
CTD	increases(expression)			ICAM1		C001329
CTD	decreases(reaction)			IL10		C001329
CTD	increases(secretion)			IL10		C001329
CTD	affects(binding)			IL12A		C001329
CTD	decreases(reaction)			IL12A		C001329
CTD	increases(secretion)			IL12A		C001329
CTD	affects(binding)			IL12B		C001329
CTD	decreases(reaction)			IL12B		C001329
CTD	increases(secretion)			IL12B		C001329
CTD	decreases(reaction)			IL6		C001329
CTD	increases(secretion)			IL6		C001329
CTD	decreases(expression)			NFKBIA		C001329
CTD	decreases(reaction)			NFKBIA		C001329
CTD	decreases(reaction)			RELA		C001329
CTD	increases(activity)			RELA		C001329
CTD	decreases(reaction)			RELA		C001329
CTD	increases(localization)			RELA		C001329
CTD	decreases(activity)			RELA		C001329
CTD	decreases(reaction)			SOD2		C001329
CTD	increases(expression)			SOD2		C001329
CTD	decreases(reaction)			TNFRSF10A		C001329
CTD	increases(expression)			TNFRSF10A		C001329
PubChem	None	uM		ABHD5	-	GI(Protien) :
PubChem	None	uM		ABHD5	-	GI(Protien) :
PubChem	IC50	uM	18.639	AGTR1	-	GI(Protien) :
PubChem	None	uM		APLNR	-	GI(Protien) :
PubChem	None	uM		APLNR	-	GI(Protien) :
PubChem	Potency	uM	0.004	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	0.006	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	2.810	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	4.108	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	7.308	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	7.308	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	19.953	ATXN2	-	GI(Protien) :
PubChem	AC50_uM	uM	0.989	CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	11.220	EHMT2	-	GI(Protien) :
PubChem	None	uM		EPAS1	-	GI(Protien) :
PubChem	Potency	uM	2.512	GLP1R	-	GI(Protien) :
PubChem	Potency	uM	0.920	GMNN	-	GI(Protien) :
PubChem	None	uM		GPR183	-	GI(Protien) :
PubChem	IC50	uM	2.642	GPR55	-	GI(Protien) :
PubChem	None	uM		HNF4A	-	GI(Protien) :
PubChem	Potency	uM	2.239	HTT	-	GI(Protien) :
PubChem	Potency	uM	1.458	IDH1	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	Potency	uM	3.548	MAPT	-	GI(Protien) :
PubChem	Potency	uM	3.981	MAPT	-	GI(Protien) :
PubChem	Mean Wild-type EC50	uM	0.180	MDM2	-	GI(Protien) :
PubChem	EC50	uM	0.420	MDM2	-	GI(Protien) :
PubChem	Mean Mutant EC50	uM	1.110	MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	None	uM		NCOA2	-	GI(Protien) :
PubChem	None	uM		NCOA2	-	GI(Protien) :
PubChem	Potency	uM	3.663	NFE2L2	-	GI(Protien) :
PubChem	IC50	uM	1.921	NR2E3	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	None	uM		NR2E3	-	GI(Protien) :
PubChem	None	uM		NR2F2	-	GI(Protien) :
PubChem	None	uM		NR2F2	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	None	uM		PAX8	-	GI(Protien) :
PubChem	None	uM		PLIN5	-	GI(Protien) :
PubChem	None	uM		PLIN5	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	None	uM		PRNP	-	GI(Protien) :
PubChem	Potency	uM	21.192	RGS4	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
PubChem	Potency	uM	3.981	SMAD3	-	GI(Protien) :
PubChem	None	uM		TNF	-	GI(Protien) :
PubChem	None	uM		TNFRSF10B	-	GI(Protien) :
PubChem	None	uM		TNFSF10	-	GI(Protien) :
PubChem	Absolute IC50 (XBP1)	uM	2.430	XBP1	-	GI(Protien) :
ChEMBL	IC50	nM	18639.000	AGTR1	-	Target : CHEMBL227
ChEMBL	Potency	nM	4107.800	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	11220.200	EHMT2	-	Target : CHEMBL6032
ChEMBL	IC50	nM	2642.280	GPR55	-	Target : CHEMBL1075322
ChEMBL	Potency	nM	2238.700	HTT	-	Target : CHEMBL5514
ChEMBL	Potency	nM	8912.500	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	3981.100	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	3548.100	MAPT	-	Target : CHEMBL1293224
ChEMBL	EC50	nM	420.000	MDM2	-	Target : CHEMBL5023
ChEMBL	Potency	nM	3662.600	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	IC50	nM	2430.000	XBP1	-	Target : CHEMBL1741176

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