Tan Lab | DSigDB

Gene Set: D4 : CTD - deguelin

Collection

D4 : CTD

Chemical Name

deguelin ( From PubChem : DEGUELIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
394.417 g/mol	0	6	4.0079	True

Structure

InChI

InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1

InChIKey

ORDAZKGHSNRHTD-UXHICEINSA-N

Links

Gene (93 / 180)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(reaction)			ADM		C107676
CTD	increases(expression)			ADM		C107676
CTD	decreases(reaction)			AKT1		C107676
CTD	increases(activity)			AKT1		C107676
CTD	increases(phosphorylation)			AKT1		C107676
CTD	decreases(expression)			AKT1		C107676
CTD	decreases(expression)			AKT1		C107676
CTD	decreases(phosphorylation)			AKT1		C107676
CTD	decreases(reaction)			ANGPTL4		C107676
CTD	increases(expression)			ANGPTL4		C107676
CTD	decreases(expression)			ATM		C107676
CTD	decreases(expression)			ATR		C107676
CTD	decreases(reaction)			BCL2		C107676
CTD	increases(expression)			BCL2		C107676
CTD	decreases(expression)			BCL2		C107676
CTD	decreases(expression)			BCL2		C107676
CTD	decreases(reaction)			BCL2L1		C107676
CTD	increases(expression)			BCL2L1		C107676
CTD	decreases(expression)			BCL2L1		C107676
CTD	decreases(expression)			BCL2L1		C107676
CTD	decreases(reaction)			BIRC5		C107676
CTD	increases(expression)			BIRC5		C107676
CTD	decreases(expression)			BIRC5		C107676
CTD	decreases(expression)			BRCA1		C107676
CTD	decreases(reaction)			CA9		C107676
CTD	increases(expression)			CA9		C107676
CTD	increases(activity)			CASP3		C107676
CTD	increases(cleavage)			CASP3		C107676
CTD	increases(expression)			CASP7		C107676
CTD	decreases(expression)			CCND1		C107676
CTD	decreases(reaction)			CCND1		C107676
CTD	decreases(reaction)			CCND1		C107676
CTD	increases(expression)			CCND1		C107676
CTD	decreases(expression)			CCND1		C107676
CTD	increases(degradation)			CCND1		C107676
CTD	increases(expression)			CDH3		C107676
CTD	increases(expression)			CDH7		C107676
CTD	increases(expression)			CDH9		C107676
CTD	decreases(expression)			CDK4		C107676
CTD	decreases(expression)			CDK4		C107676
CTD	decreases(expression)			CDKN1A		C107676
CTD	decreases(reaction)			CFLAR		C107676
CTD	increases(expression)			CFLAR		C107676
CTD	decreases(expression)			CFLAR		C107676
CTD	increases(expression)			CLDN2		C107676
CTD	increases(expression)			CLDN5		C107676
CTD	decreases(expression)			CTNNB1		C107676
CTD	decreases(reaction)			CTNNB1		C107676
CTD	increases(degradation)			CTNNB1		C107676
CTD	decreases(reaction)			CXCL8		C107676
CTD	increases(expression)			CXCL8		C107676
CTD	decreases(reaction)			CXCR4		C107676
CTD	increases(expression)			CXCR4		C107676
CTD	decreases(expression)			DKK2		C107676
CTD	increases(expression)			DKK4		C107676
CTD	decreases(expression)			EGFR		C107676
CTD	decreases(reaction)			EGLN3		C107676
CTD	increases(expression)			EGLN3		C107676
CTD	decreases(expression)			EIF4EBP1		C107676
CTD	decreases(expression)			EPAS1		C107676
CTD	increases(expression)			FRZB		C107676
CTD	increases(expression)			FZD10		C107676
CTD	increases(expression)			FZD4		C107676
CTD	increases(expression)			FZD8		C107676
CTD	decreases(phosphorylation)			GSK3B		C107676
CTD	decreases(reaction)			HIF1A		C107676
CTD	increases(degradation)			HIF1A		C107676
CTD	increases(expression)			HIF1A		C107676
CTD	decreases(reaction)			HIF1A		C107676
CTD	increases(expression)			HIF1A		C107676
CTD	decreases(reaction)			HIF1A		C107676
CTD	increases(expression)			HIF1A		C107676
CTD	decreases(reaction)			ICAM1		C107676
CTD	increases(expression)			ICAM1		C107676
CTD	decreases(reaction)			ICAM1		C107676
CTD	increases(expression)			ICAM1		C107676
CTD	decreases(reaction)			IGF1		C107676
CTD	increases(expression)			IGF1		C107676
CTD	decreases(expression)			IGF1R		C107676
CTD	increases(expression)			IHH		C107676
CTD	decreases(reaction)			IL10		C107676
CTD	increases(expression)			IL10		C107676
CTD	decreases(expression)			KDR		C107676
CTD	decreases(reaction)			LOX		C107676
CTD	increases(expression)			LOX		C107676
CTD	decreases(expression)			MAP2K1		C107676
CTD	decreases(expression)			MAP2K1		C107676
CTD	decreases(expression)			MAP2K2		C107676
CTD	decreases(expression)			MCL1		C107676
CTD	decreases(expression)			MGMT		C107676
CTD	decreases(expression)			MKI67		C107676
CTD	decreases(reaction)			MMP9		C107676
CTD	increases(expression)			MMP9		C107676
CTD	decreases(expression)			MTOR		C107676
CTD	decreases(expression)			MYC		C107676
CTD	decreases(reaction)			MYC		C107676
CTD	decreases(reaction)			MYC		C107676
CTD	increases(expression)			MYC		C107676
CTD	increases(degradation)			MYC		C107676
CTD	decreases(expression)			NCOA3		C107676
CTD	decreases(reaction)			NFKBIA		C107676
CTD	increases(degradation)			NFKBIA		C107676
CTD	increases(phosphorylation)			NFKBIA		C107676
CTD	decreases(expression)			NOS3		C107676
CTD	decreases(expression)			NUP98		C107676
CTD	increases(activity)			ODC1		C107676
CTD	decreases(reaction)			PARP1		C107676
CTD	increases(cleavage)			PARP1		C107676
CTD	increases(expression)			PARP1		C107676
CTD	increases(cleavage)			PARP1		C107676
CTD	decreases(expression)			PDK1		C107676
CTD	decreases(expression)			PIK3CA		C107676
CTD	decreases(expression)			PRKDC		C107676
CTD	decreases(reaction)			PTGS2		C107676
CTD	increases(expression)			PTGS2		C107676
CTD	decreases(expression)			RB1		C107676
CTD	affects(localization)			RELA		C107676
CTD	decreases(reaction)			RELA		C107676
CTD	increases(phosphorylation)			RELA		C107676
CTD	decreases(expression)			RELA		C107676
CTD	decreases(phosphorylation)			RELA		C107676
CTD	decreases(expression)			RPS6		C107676
CTD	decreases(expression)			RPS6KB1		C107676
CTD	decreases(expression)			SFRP2		C107676
CTD	decreases(expression)			SNAI1		C107676
CTD	increases(expression)			SOX14		C107676
CTD	increases(expression)			SOX30		C107676
CTD	increases(expression)			SOX5		C107676
CTD	increases(activity)			SRC		C107676
CTD	increases(activity)			STAT3		C107676
CTD	increases(phosphorylation)			STAT6		C107676
CTD	decreases(reaction)			STS		C107676
CTD	increases(activity)			STS		C107676
CTD	increases(expression)			TCF4		C107676
CTD	decreases(reaction)			TNF		C107676
CTD	increases(cleavage)			TNF		C107676
CTD	decreases(reaction)			TNF		C107676
CTD	increases(expression)			TNF		C107676
CTD	increases(expression)			TNF		C107676
CTD	affects(localization)			TNF		C107676
CTD	increases(phosphorylation)			TNF		C107676
CTD	increases(activity)			TNF		C107676
CTD	decreases(reaction)			TNF		C107676
CTD	increases(degradation)			TNF		C107676
CTD	increases(phosphorylation)			TNF		C107676
CTD	decreases(expression)			TP53		C107676
CTD	decreases(reaction)			VEGFA		C107676
CTD	increases(expression)			VEGFA		C107676
CTD	decreases(reaction)			VEGFA		C107676
CTD	increases(expression)			VEGFA		C107676
CTD	decreases(reaction)			VEGFA		C107676
CTD	increases(expression)			VEGFA		C107676
CTD	decreases(expression)			VEGFA		C107676
CTD	decreases(response to substance)			VEGFA		C107676
CTD	increases(expression)			WIF1		C107676
CTD	increases(expression)			WNT10A		C107676
CTD	increases(expression)			WNT11		C107676
CTD	increases(expression)			WNT2		C107676
CTD	decreases(expression)			WNT2B		C107676
CTD	decreases(expression)			WNT3A		C107676
CTD	decreases(expression)			WNT9A		C107676
CTD	decreases(expression)			XIAP		C107676
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	5.012	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	0.063	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	Potency	uM	0.106	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.150	TDP1	-	GI(Protien) :
PubChem	Potency	uM	19.953	TSHR	-	GI(Protien) :
ChEMBL	Potency	nM	5011.900	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	5011.870	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	63.100	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	63.100	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	19952.600	TSHR	-	Target : CHEMBL1963

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