Tan Lab | DSigDB

Gene Set: D4 : CTD - bexarotene

Collection

D4 : CTD

Chemical Name

bexarotene ( From PubChem : BEXAROTENE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
348.478 g/mol	1	2	6.1037	False(3/4)

Structure

InChI

InChI=1S/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)

InChIKey

NAVMQTYZDKMPEU-UHFFFAOYSA-N

Links

Gene (91 / 106)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			ADD3		C095105
CTD	increases(expression)			ADIRF		C095105
CTD	decreases(expression)			ADRB2		C095105
CTD	increases(expression)			AKR1C1		C095105
CTD	increases(expression)			AKR1C3		C095105
CTD	decreases(expression)			AMOTL2		C095105
CTD	increases(expression)			ARL6IP5		C095105
CTD	decreases(expression)			ASNS		C095105
CTD	increases(activity)			ATM		C095105
CTD	increases(activity)			BAX		C095105
CTD	increases(expression)			BAX		C095105
CTD	decreases(expression)			BIRC5		C095105
CTD	decreases(expression)			BNIP2		C095105
CTD	increases(expression)			C10ORF10		C095105
CTD	decreases(expression)			CCNB1		C095105
CTD	decreases(expression)			CDK1		C095105
CTD	increases(expression)			CDKN1A		C095105
CTD	decreases(expression)			CEBPG		C095105
CTD	decreases(expression)			COX2		C095105
CTD	decreases(expression)			CTH		C095105
CTD	increases(expression)			CTSH		C095105
CTD	decreases(expression)			CYCS		C095105
CTD	increases(expression)			CYP26A1		C095105
CTD	decreases(expression)			CYR61		C095105
CTD	increases(expression)			DDIT4		C095105
CTD	increases(expression)			DHRS3		C095105
CTD	increases(expression)			DKK1		C095105
CTD	decreases(expression)			DUSP1		C095105
CTD	decreases(expression)			DUSP5		C095105
CTD	decreases(expression)			EGR3		C095105
CTD	decreases(expression)			EIF1		C095105
CTD	decreases(expression)			EPHA2		C095105
CTD	decreases(expression)			GARS		C095105
CTD	increases(expression)			GPM6B		C095105
CTD	decreases(expression)			HERPUD1		C095105
CTD	increases(expression)			ID1		C095105
CTD	decreases(expression)			IER2		C095105
CTD	increases(expression)			IGFBP6		C095105
CTD	increases(expression)			IL15		C095105
CTD	decreases(expression)			IL4		C095105
CTD	increases(expression)			ITGB6		C095105
CTD	increases(expression)			ITM2A		C095105
CTD	increases(expression)			ITPR1		C095105
CTD	decreases(expression)			KLF10		C095105
CTD	increases(expression)			KRT15		C095105
CTD	decreases(expression)			KRT17		C095105
CTD	increases(expression)			LOXL2		C095105
CTD	increases(expression)			MAF		C095105
CTD	decreases(expression)			MAFF		C095105
CTD	increases(expression)			MLLT11		C095105
CTD	decreases(expression)			MMP1		C095105
CTD	decreases(expression)			MTHFD2		C095105
CTD	decreases(expression)			ODC1		C095105
CTD	decreases(expression)			PER2		C095105
CTD	increases(expression)			PIK3R1		C095105
CTD	increases(reaction)			PIK3R1		C095105
CTD	increases(expression)			PLAT		C095105
CTD	decreases(expression)			PLAUR		C095105
CTD	increases(expression)			PLOD2		C095105
CTD	decreases(expression)			PNO1		C095105
CTD	increases(expression)			PNRC1		C095105
CTD	increases(expression)			RARB		C095105
CTD	decreases(phosphorylation)			RB1		C095105
CTD	affects(binding)			RXRA		C095105
CTD	increases(activity)			RXRA		C095105
CTD	affects(binding)			RXRA		C095105
CTD	affects(binding)			RXRB		C095105
CTD	affects(binding)			RXRG		C095105
CTD	increases(expression)			S100A9		C095105
CTD	increases(expression)			SCD		C095105
CTD	decreases(expression)			SIAH2		C095105
CTD	affects(cotreatment)			SLC2A4		C095105
CTD	increases(expression)			SLC2A4		C095105
CTD	decreases(expression)			SLC7A1		C095105
CTD	decreases(expression)			SLC7A5		C095105
CTD	increases(expression)			SMAD5		C095105
CTD	increases(expression)			SPARC		C095105
CTD	decreases(expression)			SRSF2		C095105
CTD	increases(expression)			TGM2		C095105
CTD	increases(expression)			TM4SF1		C095105
CTD	increases(activity)			TP53		C095105
CTD	increases(phosphorylation)			TP53		C095105
CTD	increases(expression)			TP73		C095105
CTD	increases(expression)			TSC22D3		C095105
CTD	decreases(expression)			UAP1		C095105
CTD	increases(expression)			UCP2		C095105
CTD	increases(reaction)			UCP2		C095105
CTD	increases(expression)			VAMP8		C095105
CTD	decreases(expression)			XBP1		C095105
PubChem	Potency	uM	68.050	BLM	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	61.131	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.758	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.962	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	17.374	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	18.834	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	21.130	HSPB1	-	GI(Protien) :
PubChem	Potency	uM	6.310	KAT2A	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.770	NR3C1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		PPARG	-	GI(Protien) :
PubChem	Potency	uM	22.387	USP1	-	GI(Protien) :
ChEMBL	Potency	nM	68049.600	BLM	-	Target : CHEMBL1293237
ChEMBL	Potency	nM	6309.600	KAT2A	-	Target : CHEMBL5501
ChEMBL	Activity	-		NR1H3	-	Target : CHEMBL2808
ChEMBL	Activity	-		RXRA	-	Target : CHEMBL2061
ChEMBL	Activity	-		RXRA	-	Target : CHEMBL2061
ChEMBL	Activity	-		RXRA	-	Target : CHEMBL2061

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