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Gene Set: D4 : CTD - 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole

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Collection	D4 : CTD
Chemical Name	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole ( From PubChem : SB 202190 )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Not Not Not Not Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 331.343 g/mol 2 2 3.3378 True
Structure
InChI	InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H
InChIKey	NJNKPVPFGLGHPA-UHFFFAOYSA-N
Links
Gene (91 / 245) ⊖ Less	Source Type Unit Value Gene PMID Assay Other CTD decreases(reaction) ATF2 C090942 CTD increases(phosphorylation) ATF2 C090942 CTD decreases(reaction) ATF2 C090942 CTD decreases(response to substance) ATF2 C090942 CTD increases(activity) ATF2 C090942 CTD increases(phosphorylation) ATF2 C090942 CTD affects(phosphorylation) ATF2 C090942 CTD decreases(reaction) ATF2 C090942 CTD affects(localization) BAX C090942 CTD decreases(reaction) BAX C090942 CTD decreases(expression) BCL2 C090942 CTD decreases(reaction) BCL2 C090942 CTD decreases(expression) BCL2L1 C090942 CTD decreases(reaction) BCL2L1 C090942 CTD decreases(expression) BIRC5 C090942 CTD decreases(reaction) BIRC5 C090942 CTD decreases(expression) BIRC5 C090942 CTD decreases(reaction) BIRC5 C090942 CTD decreases(reaction) CASP3 C090942 CTD increases(activity) CASP3 C090942 CTD decreases(reaction) CCL11 C090942 CTD increases(expression) CCL11 C090942 CTD decreases(reaction) CCL2 C090942 CTD increases(expression) CCL2 C090942 CTD decreases(reaction) CCL26 C090942 CTD increases(expression) CCL26 C090942 CTD decreases(reaction) CCNB1 C090942 CTD increases(degradation) CCNB1 C090942 CTD increases(ubiquitination) CCNB1 C090942 CTD decreases(reaction) CCNB1 C090942 CTD increases(expression) CCNB1 C090942 CTD decreases(reaction) CCND3 C090942 CTD increases(expression) CCND3 C090942 CTD increases(reaction) CCND3 C090942 CTD decreases(expression) CCR2 C090942 CTD decreases(reaction) CCR2 C090942 CTD increases(expression) CD14 C090942 CTD increases(reaction) CD14 C090942 CTD affects(binding) CDC20 C090942 CTD decreases(reaction) CDC20 C090942 CTD increases(reaction) CDC20 C090942 CTD decreases(expression) CDC20 C090942 CTD affects(binding) CDC27 C090942 CTD decreases(reaction) CDC27 C090942 CTD increases(reaction) CDC27 C090942 CTD decreases(activity) CDK1 C090942 CTD decreases(reaction) CDK1 C090942 CTD decreases(reaction) CDKN1A C090942 CTD increases(expression) CDKN1A C090942 CTD increases(expression) CEBPB C090942 CTD increases(reaction) CEBPB C090942 CTD decreases(reaction) CHRNA5 C090942 CTD increases(expression) CHRNA5 C090942 CTD decreases(reaction) CHRNA7 C090942 CTD increases(expression) CHRNA7 C090942 CTD decreases(reaction) CREB1 C090942 CTD increases(phosphorylation) CREB1 C090942 CTD decreases(reaction) CXCL8 C090942 CTD increases(secretion) CXCL8 C090942 CTD decreases(reaction) CXCL8 C090942 CTD increases(secretion) CXCL8 C090942 CTD decreases(reaction) CXCL8 C090942 CTD increases(expression) CXCL8 C090942 CTD decreases(reaction) CXCL8 C090942 CTD increases(secretion) CXCL8 C090942 CTD increases(reaction) CXCL8 C090942 CTD decreases(reaction) CYP1A1 C090942 CTD increases(expression) CYP1A1 C090942 CTD decreases(reaction) CYP1A1 C090942 CTD increases(expression) CYP1A1 C090942 CTD decreases(reaction) CYP1A1 C090942 CTD increases(expression) CYP1A1 C090942 CTD increases(expression) CYP1A1 C090942 CTD decreases(reaction) FAS C090942 CTD increases(expression) FAS C090942 CTD decreases(reaction) FASLG C090942 CTD increases(expression) FASLG C090942 CTD decreases(reaction) FGF9 C090942 CTD increases(expression) FGF9 C090942 CTD affects(cotreatment) FOS C090942 CTD affects(localization) FOS C090942 CTD decreases(reaction) FOS C090942 CTD increases(expression) FOS C090942 CTD increases(reaction) FOS C090942 CTD decreases(reaction) GDF15 C090942 CTD increases(expression) GDF15 C090942 CTD decreases(reaction) HIF1A C090942 CTD increases(expression) HIF1A C090942 CTD decreases(reaction) HIF1A C090942 CTD increases(expression) HIF1A C090942 CTD decreases(reaction) HMOX1 C090942 CTD increases(expression) HMOX1 C090942 CTD decreases(reaction) HMOX1 C090942 CTD increases(expression) HMOX1 C090942 CTD decreases(reaction) ICAM1 C090942 CTD increases(expression) ICAM1 C090942 CTD decreases(reaction) IFNG C090942 CTD increases(expression) IFNG C090942 CTD decreases(reaction) IL10 C090942 CTD increases(reaction) IL10 C090942 CTD increases(secretion) IL10 C090942 CTD decreases(reaction) IL1A C090942 CTD increases(expression) IL1A C090942 CTD decreases(reaction) IL1B C090942 CTD increases(secretion) IL1B C090942 CTD increases(reaction) IL1B C090942 CTD decreases(reaction) IL1B C090942 CTD increases(expression) IL1B C090942 CTD decreases(reaction) IL2 C090942 CTD increases(expression) IL2 C090942 CTD decreases(reaction) IL4 C090942 CTD increases(expression) IL4 C090942 CTD decreases(reaction) IL6 C090942 CTD increases(expression) IL6 C090942 CTD decreases(reaction) IL6 C090942 CTD increases(expression) IL6 C090942 CTD decreases(reaction) IL6 C090942 CTD increases(expression) IL6 C090942 CTD decreases(reaction) IL6 C090942 CTD increases(secretion) IL6 C090942 CTD decreases(activity) IL6 C090942 CTD decreases(reaction) ITGAM C090942 CTD increases(expression) ITGAM C090942 CTD increases(expression) ITGAM C090942 CTD increases(reaction) ITGAM C090942 CTD decreases(reaction) ITGB6 C090942 CTD increases(expression) ITGB6 C090942 CTD affects(cotreatment) JUN C090942 CTD affects(localization) JUN C090942 CTD decreases(reaction) JUN C090942 CTD decreases(reaction) JUN C090942 CTD increases(phosphorylation) JUN C090942 CTD decreases(reaction) JUN C090942 CTD increases(phosphorylation) JUN C090942 CTD decreases(reaction) KLK3 C090942 CTD increases(expression) KLK3 C090942 CTD affects(binding) MAD2L1 C090942 CTD decreases(reaction) MAD2L1 C090942 CTD increases(reaction) MAD2L1 C090942 CTD increases(activity) MAPK1 C090942 CTD increases(phosphorylation) MAPK1 C090942 CTD increases(reaction) MAPK1 C090942 CTD increases(phosphorylation) MAPK1 C090942 CTD increases(reaction) MAPK1 C090942 CTD decreases(activity) MAPK14 C090942 CTD increases(activity) MAPK3 C090942 CTD increases(phosphorylation) MAPK3 C090942 CTD increases(reaction) MAPK3 C090942 CTD increases(phosphorylation) MAPK3 C090942 CTD increases(reaction) MAPK3 C090942 CTD decreases(reaction) MAPK8 C090942 CTD increases(phosphorylation) MAPK8 C090942 CTD decreases(reaction) MAPK9 C090942 CTD increases(phosphorylation) MAPK9 C090942 CTD decreases(reaction) MMP9 C090942 CTD increases(secretion) MMP9 C090942 CTD decreases(reaction) MMP9 C090942 CTD increases(activity) MMP9 C090942 CTD decreases(reaction) NGFR C090942 CTD increases(expression) NGFR C090942 CTD decreases(reaction) NOD1 C090942 CTD increases(secretion) NOD1 C090942 CTD affects(binding) PLAT C090942 CTD decreases(reaction) PLAT C090942 CTD increases(reaction) PLAT C090942 CTD increases(expression) PLAT C090942 CTD increases(secretion) PLAT C090942 CTD decreases(reaction) PLAU C090942 CTD increases(expression) PLAU C090942 CTD decreases(reaction) PTGS2 C090942 CTD increases(expression) PTGS2 C090942 CTD decreases(reaction) PTGS2 C090942 CTD increases(expression) PTGS2 C090942 CTD increases(expression) RB1 C090942 CTD increases(reaction) RB1 C090942 CTD affects(binding) SP1 C090942 CTD decreases(reaction) SP1 C090942 CTD increases(reaction) SP1 C090942 CTD affects(cotreatment) TERT C090942 CTD decreases(reaction) TERT C090942 CTD increases(expression) TERT C090942 CTD decreases(reaction) TGFA C090942 CTD increases(secretion) TGFA C090942 CTD decreases(reaction) TGFB1 C090942 CTD increases(expression) TGFB1 C090942 CTD decreases(reaction) TNF C090942 CTD increases(secretion) TNF C090942 CTD decreases(reaction) TP53 C090942 CTD increases(expression) TP53 C090942 CTD decreases(reaction) TP53 C090942 CTD increases(phosphorylation) TP53 C090942 CTD affects(localization) TPP2 C090942 CTD decreases(reaction) TPP2 C090942 CTD decreases(reaction) VEGFA C090942 CTD increases(expression) VEGFA C090942 PubChem Potency uM 56.234 CBX1 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem None uM CYP1A2 - GI(Protien) : PubChem Potency uM 0.794 CYP2C19 - GI(Protien) : PubChem Potency uM 7.943 CYP2C9 - GI(Protien) : PubChem Potency uM 5.012 CYP2D6 - GI(Protien) : PubChem Potency uM 12.589 CYP2D6 - GI(Protien) : PubChem None uM CYP2D6 - GI(Protien) : PubChem Potency uM 1.000 CYP3A4 - GI(Protien) : PubChem None uM CYP3A4 - GI(Protien) : PubChem Potency uM 12.589 EHMT2 - GI(Protien) : PubChem Potency uM 3.548 GMNN - GI(Protien) : PubChem Potency uM 7.943 MAPK1 - GI(Protien) : PubChem None uM 9.800 MAPK14 - GI(Protien) : PubChem None uM MDM2 - GI(Protien) : PubChem None uM MDM4 - GI(Protien) : PubChem Potency uM 31.623 MPHOSPH8 - GI(Protien) : PubChem Potency uM 6.513 TDP1 - GI(Protien) : PubChem Potency uM 15.067 TDP1 - GI(Protien) : PubChem None uM TNNC1 - GI(Protien) : PubChem None uM TNNI3 - GI(Protien) : PubChem None uM TNNT2 - GI(Protien) : PubChem Potency uM 17.291 YES1 GI(Protien) : ChEMBL Potency nM 56234.100 CBX1 - Target : CHEMBL1741193 ChEMBL Inhibition - CSNK1E - Target : CHEMBL4937 ChEMBL AC50 nM 15848.900 CYP1A2 - Target : CHEMBL3356 ChEMBL Potency nM 794.300 CYP2C19 - Target : CHEMBL3622 ChEMBL Potency nM 7943.300 CYP2C9 - Target : CHEMBL3397 ChEMBL AC50 nM 5011.870 CYP2D6 - Target : CHEMBL289 ChEMBL Potency nM 5011.900 CYP2D6 - Target : CHEMBL289 ChEMBL Potency nM 12589.300 CYP2D6 - Target : CHEMBL289 ChEMBL AC50 nM 501.190 CYP3A4 - Target : CHEMBL340 ChEMBL Potency nM 1000.000 CYP3A4 - Target : CHEMBL340 ChEMBL Inhibition - EGFR - Target : CHEMBL203 ChEMBL Potency nM 12589.300 EHMT2 - Target : CHEMBL6032 ChEMBL Inhibition - FRK - Target : CHEMBL4223 ChEMBL Inhibition - GAK - Target : CHEMBL4355 ChEMBL Potency nM 31622.800 HSD17B10 - Target : CHEMBL4159 ChEMBL Potency nM 7943.300 MAPK1 - Target : CHEMBL4040 ChEMBL Inhibition - MAPK10 - Target : CHEMBL2637 ChEMBL Inhibition - MAPK11 - Target : CHEMBL3961 ChEMBL Inhibition - MAPK12 - Target : CHEMBL4674 ChEMBL Inhibition - MAPK14 - Target : CHEMBL260 ChEMBL Inhibition - MAPK8 - Target : CHEMBL2276 ChEMBL Inhibition - MAPK9 - Target : CHEMBL4179 ChEMBL Potency nM 31622.800 MPHOSPH8 - Target : CHEMBL1741210 ChEMBL Inhibition - PTK6 - Target : CHEMBL4601 ChEMBL Inhibition - RIPK2 - Target : CHEMBL5014 ChEMBL Inhibition - STK36 - Target : CHEMBL4312 ChEMBL Inhibition - TNIK - Target : CHEMBL4527
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