Tan Lab | DSigDB

Gene Set: D4 : CTD - kaempferol

Collection

D4 : CTD

Chemical Name

kaempferol ( From PubChem : KAEMPFEROL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
286.236 g/mol	4	6	2.2824	True

Structure

InChI

InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H

InChIKey

IYRMWMYZSQPJKC-UHFFFAOYSA-N

Links

Gene (106 / 281)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(transport)			ABCB1		C006552
CTD	decreases(reaction)			ABCB1		C006552
CTD	increases(secretion)			ABCB1		C006552
CTD	affects(activity)			ABCC1		C006552
CTD	decreases(activity)			ABCC1		C006552
CTD	affects(binding)			AHR		C006552
CTD	decreases(reaction)			AHR		C006552
CTD	increases(activity)			AHR		C006552
CTD	decreases(reaction)			AHR		C006552
CTD	affects(binding)			AHR		C006552
CTD	decreases(reaction)			AHR		C006552
CTD	increases(reaction)			AHR		C006552
CTD	affects(binding)			AHR		C006552
CTD	decreases(reaction)			AHR		C006552
CTD	increases(reaction)			AHR		C006552
CTD	decreases(reaction)			AHR		C006552
CTD	increases(activity)			AHR		C006552
CTD	decreases(reaction)			AHR		C006552
CTD	increases(phosphorylation)			AHR		C006552
CTD	increases(activity)			AHR		C006552
CTD	decreases(reaction)			AKT1		C006552
CTD	increases(phosphorylation)			AKT1		C006552
CTD	decreases(reaction)			ALOX12		C006552
CTD	increases(chemical synthesis)			ALOX12		C006552
CTD	decreases(activity)			ALOX12		C006552
CTD	affects(binding)			ARNT		C006552
CTD	decreases(reaction)			ARNT		C006552
CTD	increases(reaction)			ARNT		C006552
CTD	decreases(reaction)			ARNT		C006552
CTD	increases(phosphorylation)			ARNT		C006552
CTD	decreases(reaction)			ATM		C006552
CTD	increases(phosphorylation)			ATM		C006552
CTD	decreases(expression)			B3GALT5		C006552
CTD	increases(expression)			BAX		C006552
CTD	decreases(reaction)			BBC3		C006552
CTD	increases(expression)			BBC3		C006552
CTD	affects(binding)			BBC3		C006552
CTD	increases(reaction)			BBC3		C006552
CTD	affects(reaction)			BBC3		C006552
CTD	decreases(expression)			BCL2		C006552
CTD	affects(binding)			BCL2L1		C006552
CTD	increases(reaction)			BCL2L1		C006552
CTD	affects(reaction)			BCL2L1		C006552
CTD	increases(cleavage)			CASP3		C006552
CTD	increases(cleavage)			CASP9		C006552
CTD	affects(cotreatment)			CCL5		C006552
CTD	decreases(expression)			CCL5		C006552
CTD	decreases(expression)			CCNB1		C006552
CTD	decreases(activity)			CDK1		C006552
CTD	increases(phosphorylation)			CDK1		C006552
CTD	increases(expression)			CDKN1A		C006552
CTD	decreases(expression)			CDKN2C		C006552
CTD	affects(localization)			CFTR		C006552
CTD	decreases(phosphorylation)			CHUK		C006552
CTD	decreases(expression)			CRP		C006552
CTD	decreases(reaction)			CSF2		C006552
CTD	increases(secretion)			CSF2		C006552
CTD	affects(localization)			CYCS		C006552
CTD	decreases(reaction)			CYCS		C006552
CTD	decreases(reaction)			CYP1A1		C006552
CTD	increases(activity)			CYP1A1		C006552
CTD	decreases(reaction)			CYP1A1		C006552
CTD	increases(expression)			CYP1A1		C006552
CTD	affects(binding)			CYP1A1		C006552
CTD	decreases(reaction)			CYP1A1		C006552
CTD	increases(reaction)			CYP1A1		C006552
CTD	affects(binding)			CYP1A1		C006552
CTD	decreases(reaction)			CYP1A1		C006552
CTD	increases(reaction)			CYP1A1		C006552
CTD	decreases(reaction)			CYP1A1		C006552
CTD	increases(expression)			CYP1A1		C006552
CTD	increases(expression)			CYP1A1		C006552
CTD	increases(reaction)			CYP1A1		C006552
CTD	decreases(activity)			CYP1A1		C006552
CTD	increases(activity)			CYP1A1		C006552
CTD	increases(expression)			CYP1A1		C006552
CTD	affects(activity)			CYP1A1		C006552
CTD	affects(cotreatment)			CYP1A1		C006552
CTD	decreases(reaction)			CYP1A1		C006552
CTD	decreases(reaction)			CYP1A2		C006552
CTD	increases(expression)			CYP1A2		C006552
CTD	decreases(activity)			CYP1A2		C006552
CTD	increases(expression)			CYP1A2		C006552
CTD	affects(binding)			CYP1B1		C006552
CTD	decreases(activity)			CYP1B1		C006552
CTD	affects(binding)			CYP1B1		C006552
CTD	decreases(reaction)			CYP1B1		C006552
CTD	increases(reaction)			CYP1B1		C006552
CTD	increases(expression)			CYP1B1		C006552
CTD	decreases(activity)			CYP1B1		C006552
CTD	decreases(expression)			CYP1B1		C006552
CTD	decreases(reaction)			CYP2C9		C006552
CTD	increases(hydroxylation)			CYP2C9		C006552
CTD	decreases(reaction)			CYP3A4		C006552
CTD	increases(degradation)			CYP3A4		C006552
CTD	decreases(activity)			CYP3A4		C006552
CTD	increases(expression)			CYP3A4		C006552
CTD	increases(abundance)			DIO2		C006552
CTD	increases(activity)			DIO2		C006552
CTD	increases(reaction)			DIO2		C006552
CTD	increases(expression)			DIO2		C006552
CTD	decreases(reaction)			ESR1		C006552
CTD	increases(expression)			ESR1		C006552
CTD	affects(reaction)			ESR1		C006552
CTD	increases(activity)			ESR1		C006552
CTD	affects(binding)			ESR1		C006552
CTD	increases(activity)			ESR1		C006552
CTD	affects(binding)			ESR1		C006552
CTD	affects(binding)			ESR1		C006552
CTD	decreases(reaction)			ESR1		C006552
CTD	affects(binding)			ESR1		C006552
CTD	decreases(reaction)			ESR1		C006552
CTD	increases(reaction)			ESR1		C006552
CTD	increases(expression)			ESR1		C006552
CTD	increases(localization)			ESR1		C006552
CTD	increases(expression)			ESR1		C006552
CTD	affects(reaction)			ESR2		C006552
CTD	increases(activity)			ESR2		C006552
CTD	affects(binding)			ESR2		C006552
CTD	increases(activity)			ESR2		C006552
CTD	affects(binding)			ESR2		C006552
CTD	affects(binding)			ESR2		C006552
CTD	decreases(reaction)			ESR2		C006552
CTD	increases(activity)			ESR2		C006552
CTD	decreases(expression)			FBP1		C006552
CTD	affects(binding)			FOS		C006552
CTD	decreases(reaction)			FOS		C006552
CTD	increases(activity)			FOS		C006552
CTD	increases(expression)			GADD45B		C006552
CTD	increases(expression)			GCLC		C006552
CTD	decreases(reaction)			GREB1		C006552
CTD	increases(expression)			GREB1		C006552
CTD	affects(binding)			GREB1		C006552
CTD	increases(reaction)			GREB1		C006552
CTD	increases(expression)			GSTA1		C006552
CTD	decreases(activity)			GSTP1		C006552
CTD	increases(phosphorylation)			H2AFX		C006552
CTD	decreases(reaction)			HBB		C006552
CTD	increases(response to substance)			HBB		C006552
CTD	decreases(reaction)			HGF		C006552
CTD	increases(phosphorylation)			HGF		C006552
CTD	decreases(reaction)			ICAM1		C006552
CTD	increases(expression)			ICAM1		C006552
CTD	decreases(reaction)			IL1B		C006552
CTD	increases(expression)			IL1B		C006552
CTD	increases(phosphorylation)			IL1B		C006552
CTD	decreases(reaction)			IL4		C006552
CTD	increases(expression)			IL4		C006552
CTD	decreases(reaction)			IL5		C006552
CTD	increases(expression)			IL5		C006552
CTD	affects(cotreatment)			IL5		C006552
CTD	decreases(expression)			IL5		C006552
CTD	affects(cotreatment)			IL6		C006552
CTD	decreases(expression)			IL6		C006552
CTD	affects(binding)			JUN		C006552
CTD	decreases(reaction)			JUN		C006552
CTD	increases(activity)			JUN		C006552
CTD	increases(expression)			JUN		C006552
CTD	increases(mutagenesis)			KMT2A		C006552
CTD	decreases(reaction)			MAPK1		C006552
CTD	increases(phosphorylation)			MAPK1		C006552
CTD	increases(phosphorylation)			MAPK1		C006552
CTD	decreases(reaction)			MAPK3		C006552
CTD	increases(phosphorylation)			MAPK3		C006552
CTD	increases(phosphorylation)			MAPK3		C006552
CTD	decreases(reaction)			MET		C006552
CTD	increases(phosphorylation)			MET		C006552
CTD	increases(expression)			MT2A		C006552
CTD	decreases(reaction)			MUC5AC		C006552
CTD	increases(expression)			MUC5AC		C006552
CTD	affects(binding)			NCOA3		C006552
CTD	increases(reaction)			NCOA3		C006552
CTD	decreases(reaction)			NFE2L2		C006552
CTD	increases(expression)			NFE2L2		C006552
CTD	decreases(phosphorylation)			NFKBIA		C006552
CTD	decreases(expression)			NOS2		C006552
CTD	increases(activity)			NR1I2		C006552
CTD	increases(activity)			NR1I3		C006552
CTD	decreases(reaction)			PGR		C006552
CTD	increases(expression)			PGR		C006552
CTD	affects(binding)			PGR		C006552
CTD	decreases(reaction)			PGR		C006552
CTD	decreases(expression)			POU5F1		C006552
CTD	increases(expression)			PPARGC1A		C006552
CTD	decreases(expression)			PSCA		C006552
CTD	decreases(reaction)			PTGS2		C006552
CTD	increases(expression)			PTGS2		C006552
CTD	decreases(expression)			PTGS2		C006552
CTD	decreases(expression)			PTGS2		C006552
CTD	affects(cotreatment)			RPA3		C006552
CTD	increases(expression)			RPA3		C006552
CTD	increases(expression)			SFN		C006552
CTD	affects(transport)			SLC2A1		C006552
CTD	decreases(reaction)			SLC2A1		C006552
CTD	decreases(activity)			SLC2A1		C006552
CTD	affects(cotreatment)			STAT2		C006552
CTD	decreases(expression)			STAT2		C006552
CTD	increases(expression)			TFAM		C006552
CTD	decreases(reaction)			TFF1		C006552
CTD	increases(expression)			TFF1		C006552
CTD	increases(expression)			TFF1		C006552
CTD	decreases(reaction)			TGFA		C006552
CTD	increases(expression)			TGFA		C006552
CTD	affects(binding)			TNF		C006552
CTD	decreases(reaction)			TNF		C006552
CTD	increases(activity)			TNF		C006552
CTD	increases(expression)			TNF		C006552
CTD	decreases(reaction)			TP53		C006552
CTD	increases(phosphorylation)			TP53		C006552
CTD	increases(expression)			TP53		C006552
CTD	affects(binding)			TP53		C006552
CTD	affects(reaction)			TP53		C006552
CTD	increases(reaction)			TP53		C006552
CTD	affects(response to substance)			TP53		C006552
CTD	increases(expression)			TP53I3		C006552
CTD	increases(expression)			TP63		C006552
CTD	increases(expression)			TP73		C006552
CTD	increases(expression)			UCP3		C006552
CTD	increases(glucuronidation)			UGT1A1		C006552
CTD	increases(glucuronidation)			UGT1A10		C006552
CTD	affects(glucuronidation)			UGT1A3		C006552
CTD	increases(glucuronidation)			UGT1A3		C006552
CTD	increases(glucuronidation)			UGT1A7		C006552
CTD	increases(glucuronidation)			UGT1A8		C006552
CTD	increases(glucuronidation)			UGT1A9		C006552
CTD	increases(expression)			UTRN		C006552
CTD	decreases(reaction)			WISP2		C006552
CTD	increases(expression)			WISP2		C006552
PubChem	None	uM		ADAM10	-	GI(Protien) :
PubChem	None	uM		ADAM17	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	30.513	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	44.553	AHR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	26.408	AR	-	GI(Protien) :
PubChem	None	uM		CHRM1	-	GI(Protien) :
PubChem	IC50	uM	9.933	CTDSP1	-	GI(Protien) :
PubChem	None	uM		CTDSP1	-	GI(Protien) :
PubChem	None	uM		CTDSP1	-	GI(Protien) :
PubChem	None	uM		CTDSP1	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP2C9	-	GI(Protien) :
PubChem	Potency	uM	10.000	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	7.943	ESR1	-	GI(Protien) :
PubChem	Potency	uM	8.912	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	18.431	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	21.797	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	21.797	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	24.238	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.264	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.441	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	33.040	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	33.246	ESR1	-	GI(Protien) :
PubChem	EC50_uM	uM	11.590	GSK3B	-	GI(Protien) :
PubChem	Potency	uM	1.585	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	28.184	HPGD	-	GI(Protien) :
PubChem	Potency	uM	12.589	MAPT	-	GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	Potency	uM	21.690	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	44.668	NR1I2	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		PAFAH1B3	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	Potency	uM	25.119	POLH	-	GI(Protien) :
PubChem	Potency	uM	79.433	POLI	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM		PPARG	-	GI(Protien) :
PubChem	IC50	uM	44.490	RACGAP1	-	GI(Protien) :
PubChem	None	uM		STK16	-	GI(Protien) :
ChEMBL	AC50	nM	79.430	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	15848.900	CYP2C9	-	Target : CHEMBL3397
ChEMBL	Potency	nM	10000.000	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	10000.000	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	15848.900	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	1584.900	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	28183.800	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	15848.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	12589.300	MAPT	-	Target : CHEMBL1293224

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