Tan Lab | DSigDB

Gene Set: D4 : CTD - letrozole

Collection

D4 : CTD

Chemical Name

letrozole ( From PubChem : LETROZOLE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
285.303 g/mol	0	5	2.65916	True

Structure

InChI

InChI=1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H

InChIKey

HPJKCIUCZWXJDR-UHFFFAOYSA-N

Links

Gene (25 / 56)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	affects(cotreatment)			CCND1		C067431
CTD	decreases(expression)			CCND1		C067431
CTD	affects(cotreatment)			CCND1		C067431
CTD	decreases(expression)			CCND1		C067431
CTD	affects(cotreatment)			CCND2		C067431
CTD	decreases(expression)			CCND2		C067431
CTD	increases(expression)			CDKN1A		C067431
CTD	affects(cotreatment)			CYCS		C067431
CTD	affects(localization)			CYCS		C067431
CTD	decreases(reaction)			CYP19A1		C067431
CTD	increases(expression)			CYP19A1		C067431
CTD	decreases(activity)			CYP19A1		C067431
CTD	increases(activity)			CYP19A1		C067431
CTD	decreases(activity)			CYP51A1		C067431
CTD	increases(expression)			DKK1		C067431
CTD	affects(cotreatment)			EIF4EBP1		C067431
CTD	decreases(activity)			EIF4EBP1		C067431
CTD	increases(phosphorylation)			EIF4EBP1		C067431
CTD	increases(expression)			FGF22		C067431
CTD	increases(expression)			FSHB		C067431
CTD	increases(expression)			LHB		C067431
CTD	increases(expression)			LIF		C067431
CTD	increases(expression)			LIFR		C067431
CTD	decreases(expression)			MKI67		C067431
CTD	decreases(reaction)			MMP2		C067431
CTD	increases(activity)			MMP2		C067431
CTD	increases(secretion)			MMP2		C067431
CTD	decreases(reaction)			MMP9		C067431
CTD	increases(activity)			MMP9		C067431
CTD	increases(secretion)			MMP9		C067431
CTD	affects(activity)			MTOR		C067431
CTD	affects(cotreatment)			MTOR		C067431
CTD	decreases(reaction)			MTOR		C067431
CTD	affects(cotreatment)			MYC		C067431
CTD	decreases(expression)			MYC		C067431
CTD	decreases(expression)			PGR		C067431
CTD	affects(activity)			RB1		C067431
CTD	affects(cotreatment)			RB1		C067431
CTD	decreases(phosphorylation)			RB1		C067431
CTD	affects(cotreatment)			RB1		C067431
CTD	decreases(expression)			RB1		C067431
CTD	affects(cotreatment)			RPS6		C067431
CTD	decreases(phosphorylation)			RPS6		C067431
CTD	decreases(reaction)			SLC22A2		C067431
CTD	increases(uptake)			SLC22A2		C067431
CTD	decreases(reaction)			TERT		C067431
CTD	increases(activity)			TERT		C067431
PubChem	Potency-Replicate_1	uM	0.009	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.014	CYP19A1	-	GI(Protien) :
PubChem	None	uM		CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	5.012	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	None	uM		DRD2	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP19A1	-	Target : CHEMBL1978
ChEMBL	AC50	nM	5011.870	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	5011.900	CYP3A4	-	Target : CHEMBL340

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