Tan Lab | DSigDB

Gene Set: D4 : CTD - docetaxel

Collection

D4 : CTD

Chemical Name

docetaxel ( From PubChem : DOCETAXEL )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
807.879 g/mol	5	15	3.6505	False(2/4)

Structure

InChI

InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28?,30-,31+,32+,33?,35-,41+,42-,43+/m0/s1

InChIKey

ZDZOTLJHXYCWBA-GSQVOXQYSA-N

Links

Gene (110 / 311)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(response to substance)			ABCA1		C067311
CTD	increases(expression)			ABCA1		C067311
CTD	decreases(response to substance)			ABCA10		C067311
CTD	increases(expression)			ABCA10		C067311
CTD	decreases(response to substance)			ABCA11P		C067311
CTD	increases(expression)			ABCA11P		C067311
CTD	affects(expression)			ABCA12		C067311
CTD	decreases(response to substance)			ABCA12		C067311
CTD	decreases(expression)			ABCA3		C067311
CTD	decreases(response to substance)			ABCA3		C067311
CTD	decreases(response to substance)			ABCA4		C067311
CTD	increases(expression)			ABCA4		C067311
CTD	decreases(response to substance)			ABCA5		C067311
CTD	increases(expression)			ABCA5		C067311
CTD	decreases(response to substance)			ABCA6		C067311
CTD	increases(expression)			ABCA6		C067311
CTD	decreases(expression)			ABCA7		C067311
CTD	decreases(response to substance)			ABCA7		C067311
CTD	decreases(response to substance)			ABCA8		C067311
CTD	increases(expression)			ABCA8		C067311
CTD	decreases(response to substance)			ABCA9		C067311
CTD	increases(expression)			ABCA9		C067311
CTD	increases(response to substance)			ABCB1		C067311
CTD	decreases(response to substance)			ABCB1		C067311
CTD	decreases(reaction)			ABCB1		C067311
CTD	decreases(response to substance)			ABCB1		C067311
CTD	decreases(expression)			ABCB1		C067311
CTD	decreases(response to substance)			ABCB1		C067311
CTD	increases(expression)			ABCB1		C067311
CTD	increases(activity)			ABCB1		C067311
CTD	increases(expression)			ABCB1		C067311
CTD	increases(expression)			ABCB1		C067311
CTD	increases(expression)			ABCB1		C067311
CTD	increases(expression)			ABCB1		C067311
CTD	increases(reaction)			ABCB1		C067311
CTD	affects(reaction)			ABCB1		C067311
CTD	decreases(response to substance)			ABCB4		C067311
CTD	increases(expression)			ABCB4		C067311
CTD	decreases(response to substance)			ABCB6		C067311
CTD	increases(expression)			ABCB6		C067311
CTD	decreases(expression)			ABCB8		C067311
CTD	decreases(response to substance)			ABCB8		C067311
CTD	decreases(response to substance)			ABCC1		C067311
CTD	increases(expression)			ABCC1		C067311
CTD	increases(expression)			ABCC1		C067311
CTD	decreases(expression)			ABCC10		C067311
CTD	decreases(response to substance)			ABCC10		C067311
CTD	decreases(response to substance)			ABCC11		C067311
CTD	increases(expression)			ABCC11		C067311
CTD	affects(transport)			ABCC2		C067311
CTD	decreases(expression)			ABCC2		C067311
CTD	decreases(response to substance)			ABCC2		C067311
CTD	increases(reaction)			ABCC2		C067311
CTD	decreases(response to substance)			ABCC3		C067311
CTD	increases(expression)			ABCC3		C067311
CTD	decreases(expression)			ABCC4		C067311
CTD	decreases(response to substance)			ABCC4		C067311
CTD	decreases(response to substance)			ABCC5		C067311
CTD	increases(expression)			ABCC5		C067311
CTD	affects(response to substance)			ABCC6		C067311
CTD	affects(expression)			ABCC6		C067311
CTD	decreases(response to substance)			ABCC6		C067311
CTD	decreases(response to substance)			ABCC9		C067311
CTD	increases(expression)			ABCC9		C067311
CTD	decreases(expression)			ABCD2		C067311
CTD	decreases(response to substance)			ABCD2		C067311
CTD	decreases(expression)			ABCE1		C067311
CTD	decreases(response to substance)			ABCE1		C067311
CTD	affects(response to substance)			ABCG1		C067311
CTD	decreases(expression)			ABCG2		C067311
CTD	decreases(response to substance)			ABCG2		C067311
CTD	affects(cotreatment)			AKT1		C067311
CTD	decreases(phosphorylation)			AKT1		C067311
CTD	decreases(localization)			AR		C067311
CTD	decreases(expression)			AR		C067311
CTD	increases(degradation)			AR		C067311
CTD	decreases(phosphorylation)			BAD		C067311
CTD	increases(reaction)			BAD		C067311
CTD	decreases(reaction)			BAK1		C067311
CTD	increases(activity)			BAK1		C067311
CTD	affects(folding)			BAK1		C067311
CTD	decreases(reaction)			BAK1		C067311
CTD	increases(activity)			BAK1		C067311
CTD	increases(reaction)			BAK1		C067311
CTD	increases(expression)			BAX		C067311
CTD	increases(reaction)			BAX		C067311
CTD	decreases(reaction)			BAX		C067311
CTD	increases(activity)			BAX		C067311
CTD	affects(folding)			BAX		C067311
CTD	decreases(reaction)			BAX		C067311
CTD	increases(activity)			BAX		C067311
CTD	affects(localization)			BAX		C067311
CTD	affects(cotreatment)			BAX		C067311
CTD	increases(expression)			BAX		C067311
CTD	increases(expression)			BAX		C067311
CTD	increases(expression)			BAX		C067311
CTD	increases(reaction)			BAX		C067311
CTD	decreases(activity)			BCL2		C067311
CTD	increases(phosphorylation)			BCL2		C067311
CTD	increases(reaction)			BCL2		C067311
CTD	decreases(reaction)			BCL2		C067311
CTD	increases(phosphorylation)			BCL2		C067311
CTD	affects(folding)			BCL2		C067311
CTD	decreases(reaction)			BCL2		C067311
CTD	increases(activity)			BCL2		C067311
CTD	increases(cleavage)			BCL2		C067311
CTD	increases(expression)			BCL2		C067311
CTD	increases(reaction)			BCL2		C067311
CTD	decreases(reaction)			BCL2		C067311
CTD	increases(phosphorylation)			BCL2		C067311
CTD	decreases(reaction)			BCL2		C067311
CTD	increases(phosphorylation)			BCL2		C067311
CTD	affects(cotreatment)			BCL2		C067311
CTD	decreases(expression)			BCL2		C067311
CTD	decreases(response to substance)			BCL2L1		C067311
CTD	affects(cotreatment)			BCL2L1		C067311
CTD	decreases(expression)			BCL2L1		C067311
CTD	decreases(expression)			BCL2L1		C067311
CTD	decreases(reaction)			BCL2L11		C067311
CTD	increases(degradation)			BCL2L11		C067311
CTD	decreases(response to substance)			BIRC5		C067311
CTD	decreases(reaction)			BIRC5		C067311
CTD	increases(expression)			BIRC5		C067311
CTD	affects(response to substance)			BUB1B		C067311
CTD	increases(activity)			CASP2		C067311
CTD	increases(activity)			CASP2		C067311
CTD	increases(cleavage)			CASP2		C067311
CTD	decreases(reaction)			CASP3		C067311
CTD	increases(activity)			CASP3		C067311
CTD	increases(cleavage)			CASP3		C067311
CTD	increases(activity)			CASP3		C067311
CTD	increases(expression)			CASP3		C067311
CTD	increases(reaction)			CASP3		C067311
CTD	decreases(reaction)			CASP3		C067311
CTD	increases(activity)			CASP3		C067311
CTD	increases(activity)			CASP3		C067311
CTD	increases(activity)			CASP3		C067311
CTD	increases(cleavage)			CASP3		C067311
CTD	increases(cleavage)			CASP3		C067311
CTD	affects(cotreatment)			CASP3		C067311
CTD	decreases(expression)			CASP3		C067311
CTD	increases(activity)			CASP8		C067311
CTD	decreases(reaction)			CASP9		C067311
CTD	increases(activity)			CASP9		C067311
CTD	increases(cleavage)			CASP9		C067311
CTD	increases(activity)			CASP9		C067311
CTD	increases(cleavage)			CASP9		C067311
CTD	increases(reaction)			CASP9		C067311
CTD	increases(activity)			CASP9		C067311
CTD	increases(cleavage)			CASP9		C067311
CTD	increases(activity)			CCNB1		C067311
CTD	increases(expression)			CCNB1		C067311
CTD	decreases(reaction)			CDK1		C067311
CTD	increases(activity)			CDK1		C067311
CTD	increases(response to substance)			CDK1		C067311
CTD	decreases(reaction)			CDK2		C067311
CTD	increases(activity)			CDK2		C067311
CTD	affects(cotreatment)			CDKN1A		C067311
CTD	decreases(response to substance)			CDKN1A		C067311
CTD	increases(expression)			CDKN1A		C067311
CTD	affects(cotreatment)			CDKN1A		C067311
CTD	increases(expression)			CDKN1A		C067311
CTD	decreases(reaction)			CDKN1A		C067311
CTD	decreases(expression)			CDKN2A		C067311
CTD	affects(response to substance)			CHFR		C067311
CTD	decreases(response to substance)			CHFR		C067311
CTD	increases(secretion)			CSF2		C067311
CTD	decreases(expression)			CYP19A1		C067311
CTD	affects(response to substance)			CYP1A2		C067311
CTD	affects(response to substance)			CYP1B1		C067311
CTD	affects(response to substance)			CYP2D6		C067311
CTD	increases(response to substance)			CYP3A4		C067311
CTD	increases(expression)			CYP3A4		C067311
CTD	affects(cotreatment)			DPYD		C067311
CTD	decreases(expression)			DPYD		C067311
CTD	decreases(reaction)			DPYD		C067311
CTD	increases(activity)			DPYD		C067311
CTD	decreases(activity)			DPYD		C067311
CTD	increases(expression)			DPYD		C067311
CTD	affects(cotreatment)			EGFR		C067311
CTD	increases(response to substance)			EGFR		C067311
CTD	increases(response to substance)			EGFR		C067311
CTD	affects(cotreatment)			ERBB2		C067311
CTD	affects(response to substance)			ERBB2		C067311
CTD	affects(cotreatment)			ERBB2		C067311
CTD	affects(response to substance)			ERBB2		C067311
CTD	increases(response to substance)			ERBB2		C067311
CTD	decreases(response to substance)			F2R		C067311
CTD	increases(expression)			FAS		C067311
CTD	increases(expression)			FAS		C067311
CTD	affects(cotreatment)			FGF2		C067311
CTD	decreases(expression)			FGF2		C067311
CTD	affects(response to substance)			FMO2		C067311
CTD	affects(response to substance)			FMO3		C067311
CTD	increases(expression)			GADD45A		C067311
CTD	increases(response to substance)			GADD45A		C067311
CTD	increases(response to substance)			GSTP1		C067311
CTD	decreases(reaction)			H2AFX		C067311
CTD	increases(expression)			H2AFX		C067311
CTD	increases(reaction)			H2AFX		C067311
CTD	increases(activity)			HRAS		C067311
CTD	increases(expression)			HRAS		C067311
CTD	increases(expression)			IL6		C067311
CTD	increases(phosphorylation)			JUN		C067311
CTD	increases(reaction)			JUN		C067311
CTD	decreases(response to substance)			KIF12		C067311
CTD	decreases(response to substance)			KIF5A		C067311
CTD	decreases(response to substance)			KIFC3		C067311
CTD	decreases(expression)			KLK3		C067311
CTD	decreases(secretion)			KLK3		C067311
CTD	increases(expression)			KRT18		C067311
CTD	increases(metabolic processing)			KRT18		C067311
CTD	affects(response to substance)			MAD2L1		C067311
CTD	increases(activity)			MAPK1		C067311
CTD	increases(phosphorylation)			MAPK1		C067311
CTD	increases(phosphorylation)			MAPK1		C067311
CTD	increases(activity)			MAPK3		C067311
CTD	increases(phosphorylation)			MAPK3		C067311
CTD	increases(phosphorylation)			MAPK3		C067311
CTD	decreases(response to substance)			MCAM		C067311
CTD	increases(expression)			MCL1		C067311
CTD	decreases(reaction)			MCL1		C067311
CTD	affects(cotreatment)			MCM2		C067311
CTD	decreases(expression)			MCM2		C067311
CTD	increases(expression)			MDM2		C067311
CTD	affects(cotreatment)			MMP9		C067311
CTD	decreases(expression)			MMP9		C067311
CTD	increases(expression)			NPPB		C067311
CTD	affects(binding)			NR1I2		C067311
CTD	increases(activity)			NR1I2		C067311
CTD	increases(activity)			NR1I2		C067311
CTD	increases(expression)			NR1I2		C067311
CTD	increases(reaction)			NR1I2		C067311
CTD	decreases(reaction)			PARP1		C067311
CTD	increases(cleavage)			PARP1		C067311
CTD	decreases(reaction)			PARP1		C067311
CTD	increases(cleavage)			PARP1		C067311
CTD	increases(cleavage)			PARP1		C067311
CTD	increases(expression)			PARP1		C067311
CTD	increases(reaction)			PARP1		C067311
CTD	increases(cleavage)			PARP1		C067311
CTD	increases(reaction)			PARP1		C067311
CTD	increases(cleavage)			PARP1		C067311
CTD	decreases(expression)			PGR		C067311
CTD	increases(response to substance)			POR		C067311
CTD	increases(cleavage)			PSIP1		C067311
CTD	increases(expression)			PTGS2		C067311
CTD	increases(cleavage)			PTK2		C067311
CTD	affects(cotreatment)			RAD50		C067311
CTD	decreases(expression)			RAD50		C067311
CTD	increases(expression)			RAF1		C067311
CTD	affects(cotreatment)			RB1		C067311
CTD	decreases(expression)			RB1		C067311
CTD	decreases(phosphorylation)			RB1		C067311
CTD	increases(response to substance)			RGS10		C067311
CTD	increases(response to substance)			RGS17		C067311
CTD	decreases(expression)			TNF		C067311
CTD	decreases(reaction)			TNFRSF10A		C067311
CTD	increases(expression)			TNFRSF10A		C067311
CTD	decreases(reaction)			TNFRSF10B		C067311
CTD	increases(expression)			TNFRSF10B		C067311
CTD	increases(cleavage)			TNFSF10		C067311
CTD	increases(reaction)			TNFSF10		C067311
CTD	affects(cotreatment)			TP53		C067311
CTD	increases(expression)			TP53		C067311
CTD	decreases(expression)			TP53		C067311
CTD	decreases(ubiquitination)			TP53		C067311
CTD	increases(expression)			TP53		C067311
CTD	decreases(expression)			TP53		C067311
CTD	increases(expression)			TP53		C067311
CTD	increases(expression)			TP53		C067311
CTD	increases(ubiquitination)			TP53		C067311
CTD	affects(cotreatment)			TP53		C067311
CTD	increases(expression)			TP53		C067311
CTD	decreases(response to substance)			TP53		C067311
CTD	affects(reaction)			TP53		C067311
CTD	decreases(reaction)			TP53		C067311
CTD	increases(expression)			TP53		C067311
CTD	increases(expression)			TUBB		C067311
CTD	decreases(reaction)			TUBB		C067311
CTD	increases(response to substance)			TUBB		C067311
CTD	decreases(response to substance)			TUBB		C067311
CTD	affects(cotreatment)			TYMP		C067311
CTD	increases(expression)			TYMP		C067311
CTD	decreases(reaction)			TYMS		C067311
CTD	increases(activity)			TYMS		C067311
CTD	increases(expression)			TYMS		C067311
CTD	decreases(expression)			TYMS		C067311
CTD	increases(reaction)			TYMS		C067311
CTD	affects(cotreatment)			TYMS		C067311
CTD	increases(response to substance)			TYMS		C067311
CTD	affects(cotreatment)			UMPS		C067311
CTD	increases(expression)			UMPS		C067311
CTD	increases(reaction)			UMPS		C067311
CTD	decreases(expression)			VEGFA		C067311
CTD	increases(reaction)			VEGFA		C067311
CTD	decreases(expression)			XIAP		C067311
CTD	decreases(response to substance)			XIAP		C067311
CTD	affects(cotreatment)			XRCC5		C067311
CTD	decreases(expression)			XRCC5		C067311
CTD	affects(cotreatment)			XRCC6		C067311
CTD	decreases(expression)			XRCC6		C067311
PubChem	Ratio Potency (uM)	uM	0.005	AR	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	0.060	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.060	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.682	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.001	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.001	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.003	TDP1	-	GI(Protien) :
PubChem	Potency	uM	0.003	TDP1	-	GI(Protien) :

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