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Gene Set: D4 : CTD - topiramate

Collection D4 : CTD
Chemical Name topiramate ( From PubChem : TOPIRAMATE )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
ApprovedNotNotApprovedApprovedNotNotNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
339.362 g/mol 1 9 1.3857 True
Structure
InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
InChIKey KJADKKWYZYXHBB-XBWDGYHZSA-N
Links

Gene (12 / 17)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
CTDaffects(binding)CA1
C052342
CTDdecreases(activity)CA1
C052342
CTDdecreases(activity)CA12
C052342
CTDaffects(binding)CA2
C052342
CTDdecreases(activity)CA2
C052342
CTDdecreases(activity)CA2
C052342
CTDaffects(binding)CA3
C052342
CTDdecreases(activity)CA3
C052342
CTDdecreases(activity)CYP17A1
C052342
CTDincreases(activity)CYP3A4
C052342
CTDincreases(expression)CYP3A4
C052342
CTDaffects(response to substance)GRIK1
C052342
CTDdecreases(activity)HSD3B2
C052342
CTDdecreases(activity)KCNH2
C052342
CTDincreases(activity)NR1I2
C052342
CTDaffects(response to substance)UGT2B7
C052342
ChEMBLActivity-AQP4
-Target : CHEMBL5964
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