Tan Lab | DSigDB

Gene Set: D4 : CTD - lamotrigine

Collection

D4 : CTD

Chemical Name

lamotrigine ( From PubChem : LAMOTRIGINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
256.091 g/mol	2	5	3.1722	True

Structure

InChI

InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

InChIKey

Links

Gene (23 / 35)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
CTD	decreases(activity)			ABCB1		C047781
CTD	decreases(activity)			CYP17A1		C047781
CTD	decreases(activity)			CYP19A1		C047781
CTD	decreases(reaction)			CYP2A6		C047781
CTD	increases(glutathionylation)			CYP2A6		C047781
CTD	increases(activity)			CYP2A6		C047781
CTD	increases(glutathionylation)			CYP2B6		C047781
CTD	increases(glutathionylation)			CYP2D6		C047781
CTD	increases(glutathionylation)			CYP2E1		C047781
CTD	decreases(reaction)			CYP2E1		C047781
CTD	increases(glutathionylation)			CYP3A4		C047781
CTD	increases(response to substance)			DBH		C047781
CTD	increases(response to substance)			DRD2		C047781
CTD	affects(response to substance)			HLA-B		C047781
CTD	increases(response to substance)			HRH1		C047781
CTD	decreases(activity)			HSD3B2		C047781
CTD	decreases(activity)			KCNH2		C047781
CTD	increases(response to substance)			MC2R		C047781
CTD	increases(response to substance)			NR3C1		C047781
CTD	decreases(activity)			SCN2A		C047781
CTD	increases(glucuronidation)			UGT1A3		C047781
CTD	increases(activity)			UGT1A4		C047781
CTD	increases(glucuronidation)			UGT1A4		C047781
CTD	increases(glucuronidation)			UGT1A4		C047781
PubChem	Potency	uM	6.310	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
ChEMBL	Activity	-		AQP4	-	Target : CHEMBL5964
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	6309.600	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	6309.570	CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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