Tan Lab | DSigDB

Gene Set: D4 : CTD - ellipticine

Collection

D4 : CTD

Chemical Name

ellipticine ( From PubChem : ELLIPTICINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
246.306 g/mol	1	1	4.4861	True

Structure

InChI

InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3

InChIKey

CTSPAMFJBXKSOY-UHFFFAOYSA-N

Links

Gene (92 / 184)

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Source	Type	Unit	Value	Gene	PMID	Other
CTD	increases(expression)			BAX		C034192
CTD	decreases(expression)			BCL2		C034192
CTD	decreases(expression)			BID		C034192
CTD	increases(cleavage)			BID		C034192
CTD	decreases(reaction)			CASP3		C034192
CTD	increases(activity)			CASP3		C034192
CTD	increases(cleavage)			CASP3		C034192
CTD	increases(activity)			CASP3		C034192
CTD	decreases(reaction)			CASP7		C034192
CTD	increases(activity)			CASP7		C034192
CTD	increases(cleavage)			CASP7		C034192
CTD	increases(activity)			CASP8		C034192
CTD	increases(cleavage)			CASP8		C034192
CTD	increases(activity)			CASP9		C034192
CTD	increases(activity)			CASP9		C034192
CTD	increases(cleavage)			CASP9		C034192
CTD	decreases(expression)			CCNB1		C034192
CTD	increases(expression)			CCNB1		C034192
CTD	decreases(expression)			CCND1		C034192
CTD	decreases(expression)			CDC25C		C034192
CTD	decreases(expression)			CDK1		C034192
CTD	increases(phosphorylation)			CDK1		C034192
CTD	decreases(expression)			CDKN1B		C034192
CTD	increases(metabolic processing)			CYP1A1		C034192
CTD	decreases(reaction)			CYP1A1		C034192
CTD	increases(activity)			CYP1A1		C034192
CTD	increases(metabolic processing)			CYP1A2		C034192
CTD	decreases(reaction)			CYP1A2		C034192
CTD	increases(activity)			CYP1A2		C034192
CTD	increases(metabolic processing)			CYP1B1		C034192
CTD	increases(metabolic processing)			CYP2C19		C034192
CTD	increases(metabolic processing)			CYP2C9		C034192
CTD	increases(metabolic processing)			CYP2D6		C034192
CTD	increases(metabolic processing)			CYP2E1		C034192
CTD	affects(cotreatment)			CYP3A4		C034192
CTD	increases(oxidation)			CYP3A4		C034192
CTD	increases(metabolic processing)			CYP3A4		C034192
CTD	decreases(reaction)			MAPK1		C034192
CTD	increases(phosphorylation)			MAPK1		C034192
CTD	decreases(reaction)			MAPK3		C034192
CTD	increases(phosphorylation)			MAPK3		C034192
CTD	decreases(response to substance)			MDM2		C034192
CTD	increases(cleavage)			PARP1		C034192
CTD	affects(cotreatment)			POR		C034192
CTD	increases(oxidation)			POR		C034192
CTD	decreases(response to substance)			TOP2B		C034192
CTD	increases(response to substance)			TOP2B		C034192
CTD	decreases(expression)			XIAP		C034192
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	None	uM		AHR	-	GI(Protien) :
PubChem	None	uM		APAF1	-	GI(Protien) :
PubChem	Potency	uM	10.000	APOBEC3F	-	GI(Protien) :
PubChem	Potency	uM	14.581	APOBEC3G	-	GI(Protien) :
PubChem	None	uM		APP	-	GI(Protien) :
PubChem	Potency	uM	16.354	ATAD5	-	GI(Protien) :
PubChem	Potency	uM	56.234	BAZ2B	-	GI(Protien) :
PubChem	None	uM		BCL2L1	-	GI(Protien) :
PubChem	EC50_1	uM	3.990	CACNA1H	-	GI(Protien) :
PubChem	None	uM		CACNA1H	-	GI(Protien) :
PubChem	None	uM		CACNA1H	-	GI(Protien) :
PubChem	Potency	uM	50.119	CBX1	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CLK3	-	GI(Protien) :
PubChem	None	uM		CRHBP	-	GI(Protien) :
PubChem	None	uM		CRHR2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	3.162	CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2C19	-	GI(Protien) :
PubChem	None	uM		CYP2C19	-	GI(Protien) :
PubChem	Potency	uM	6.310	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	31.623	CYP2D6	-	GI(Protien) :
PubChem	None	uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	0.159	CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	0.398	CYP3A4	-	GI(Protien) :
PubChem	None	uM		CYP3A4	-	GI(Protien) :
PubChem	Potency	uM	10.000	DRD1	-	GI(Protien) :
PubChem	None	uM		DRD1	-	GI(Protien) :
PubChem	Potency	uM	21.192	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	10.621	FEN1	-	GI(Protien) :
PubChem	Potency	uM	11.917	FEN1	-	GI(Protien) :
PubChem	Potency	uM	35.481	GAA	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	Potency	uM	5.805	GMNN	-	GI(Protien) :
PubChem	Potency	uM	7.080	GMNN	-	GI(Protien) :
PubChem	Potency	uM	7.308	GMNN	-	GI(Protien) :
PubChem	None	uM		GNAO1	-	GI(Protien) :
PubChem	None	uM		GNAO1	-	GI(Protien) :
PubChem	IC50	uM		GPR35	-	GI(Protien) :
PubChem	Potency	uM	12.589	HBB	-	GI(Protien) :
PubChem	Potency	uM	31.623	HBB	-	GI(Protien) :
PubChem	Potency	uM	5.012	HIF1A	-	GI(Protien) :
PubChem	Potency	uM	10.322	IDH1	-	GI(Protien) :
PubChem	None	uM		IL1B	-	GI(Protien) :
PubChem	None	uM		INS	-	GI(Protien) :
PubChem	None	uM		JAK2	-	GI(Protien) :
PubChem	Potency	uM	19.953	KCNH2		GI(Protien) :
PubChem	Potency	uM	19.953	KCNH2		GI(Protien) :
PubChem	None	uM		MAP1LC3A	-	GI(Protien) :
PubChem	None	uM		MAP3K3	-	GI(Protien) :
PubChem	None	uM		MAP3K5	-	GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	None	uM		MAP4K2	-	GI(Protien) :
PubChem	Potency	uM	10.000	MAPT	-	GI(Protien) :
PubChem	Potency	uM	11.220	MAPT	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM2	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MDM4	-	GI(Protien) :
PubChem	None	uM		MITF	-	GI(Protien) :
PubChem	None	uM		NCF1	-	GI(Protien) :
PubChem	None	uM		NCOA1	-	GI(Protien) :
PubChem	None	uM		NCOA1	-	GI(Protien) :
PubChem	Potency	uM	7.308	NFE2L2	-	GI(Protien) :
PubChem	None	uM		NLRP1	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NLRP3	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		PIM1	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	Potency	uM	3.981	POLB	-	GI(Protien) :
PubChem	Potency	uM	15.849	POLB	-	GI(Protien) :
PubChem	Potency	uM	14.125	POLI	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		PPP1CA	-	GI(Protien) :
PubChem	None	uM		PRKACA	-	GI(Protien) :
PubChem	None	uM		PRKACA	-	GI(Protien) :
PubChem	None	uM		PRKD1	-	GI(Protien) :
PubChem	Potency	uM	31.623	PTBP1	-	GI(Protien) :
PubChem	None	uM		PTBP1	-	GI(Protien) :
PubChem	None	uM		RAD54L	-	GI(Protien) :
PubChem	None	uM		RGS4	-	GI(Protien) :
PubChem	None	uM		ROCK2	-	GI(Protien) :
PubChem	None	uM		ROCK2	-	GI(Protien) :
PubChem	Potency	uM	15.849	STAT6	-	GI(Protien) :
PubChem	None	uM		STK33	-	GI(Protien) :
PubChem	Potency	uM	1.458	TDP1	-	GI(Protien) :
PubChem	Potency	uM	2.311	TDP1	-	GI(Protien) :
PubChem	Potency	uM	10.000	THPO	-	GI(Protien) :
PubChem	Potency	uM	10.000	TP53	-	GI(Protien) :
PubChem	Potency	uM	12.589	TP53	-	GI(Protien) :
PubChem	Potency	uM	12.589	TP53	-	GI(Protien) :
ChEMBL	Potency	nM	3162.300	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	16353.500	ATAD5	-	Target : CHEMBL1741209
ChEMBL	Potency	nM	56234.100	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	EC50	nM	3990.000	CACNA1H	-	Target : CHEMBL1859
ChEMBL	Potency	nM	50118.700	CBX1	-	Target : CHEMBL1741193
ChEMBL	AC50	nM	19.950	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	3162.300	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	3162.280	CYP2C19	-	Target : CHEMBL3622
ChEMBL	Potency	nM	6309.600	CYP2C19	-	Target : CHEMBL3622
ChEMBL	AC50	nM	6309.570	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	31622.800	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	6309.600	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	158.490	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	158.500	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	398.100	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	10000.000	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	21192.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	10621.300	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	35481.300	GAA	-	Target : CHEMBL2608
ChEMBL	Potency	nM	7079.500	GMNN	-	Target : CHEMBL1293278
ChEMBL	Potency	nM	12589.300	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	31622.800	HBB	-	Target : CHEMBL4331
ChEMBL	Potency	nM	5011.900	HIF1A	-	Target : CHEMBL4261
ChEMBL	Potency	nM	12589.300	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	10000.000	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	11220.200	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	7307.800	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	15848.900	POLB	-	Target : CHEMBL2392
ChEMBL	Potency	nM	3981.100	POLB	-	Target : CHEMBL2392
ChEMBL	Potency	nM	31622.800	PTBP1	-	Target : CHEMBL1293230
ChEMBL	Potency	nM	10000.000	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	4466.800	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	15848.900	STAT6	-	Target : CHEMBL5401
ChEMBL	Potency	nM	50118.700	TDP1	-	Target : CHEMBL1075138
ChEMBL	Potency	nM	10000.000	THPO	-	Target : CHEMBL1293256
ChEMBL	Inhibition	-		TOP2A	-	Target : CHEMBL1806
ChEMBL	Activity	-		TOP2A	-	Target : CHEMBL1806
ChEMBL	Potency	nM	10000.000	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	12589.300	TP53	-	Target : CHEMBL4096
ChEMBL	Potency	nM	12589.300	TP53	-	Target : CHEMBL4096

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