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Drug SIGnatures DataBase Collection of Annoated Drug / Compound Gene Sets

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Gene Set: D4 : Boss - fulvestrant-supplied by selleck chemicals

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Collection	D4 : Boss
Chemical Name	fulvestrant-supplied by selleck chemicals ( From PubChem : FULVESTRANT )
FDA NPC WHO Indian Australia China Traditional Herbal Clinical Trail Approved Not Not Approved Not Not Not Not
Molecular Weight Hydrogen Bond Donor Count Hydrogen Bond Acceptor Count cLogP Lipinski Rule 606.771 g/mol 2 3 9.5483 False(2/4)
Structure
InChI	InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41-/m1/s1
InChIKey	VWUXBMIQPBEWFH-CIAKRVSBSA-N
Links
Gene (32 / 53) ⊖ Less	Source Type Unit Value Gene PMID Assay Other BOSS Text Mining ABCA1 BOSS Text Mining AKR1B1 BOSS Text Mining BCL2 BOSS Text Mining CDT1 BOSS Text Mining DDR2 BOSS Text Mining EGF BOSS Text Mining EGFR BOSS Text Mining EPHB2 BOSS Text Mining ERBB2 BOSS Text Mining ERBB2 BOSS Text Mining ERBB3 BOSS Text Mining EREG BOSS Text Mining ESR1 BOSS Text Mining ESR2 BOSS Text Mining IGFBP1 BOSS Text Mining MAPK3 BOSS Text Mining MERTK BOSS Text Mining MTOR BOSS Text Mining MYC BOSS Text Mining NR4A1 BOSS Text Mining PCNA BOSS Text Mining PGR BOSS Text Mining PRL BOSS Text Mining TP53 BOSS Text Mining TSC1 BOSS Text Mining VEGFA PubChem Ratio Potency (uM) uM 7.184 AR - GI(Protien) : PubChem Potency-Replicate_1 uM 0.015 CYP19A1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.060 CYP19A1 - GI(Protien) : PubChem None uM CYP19A1 - GI(Protien) : PubChem ER Potency (uM) uM 0.007 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.009 ESR1 - GI(Protien) : PubChem ER Potency (uM) uM 0.022 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 0.025 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.030 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 0.111 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 0.601 ESR1 - GI(Protien) : PubChem Potency-Replicate_1 uM 3.465 ESR1 - GI(Protien) : PubChem Ratio Potency (uM) uM 17.211 NFE2L2 - GI(Protien) : PubChem None uM NR1H4 - GI(Protien) : PubChem Potency-Replicate_1 uM 1.229 NR3C1 - GI(Protien) : PubChem None uM NR3C1 - GI(Protien) : ChEMBL Inhibition - EPHX2 - Target : CHEMBL2409 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR1 - Target : CHEMBL206 ChEMBL Activity - ESR2 - Target : CHEMBL242 ChEMBL Activity - ESRRA - Target : CHEMBL3429
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