Tan Lab | DSigDB

Gene Set: D1 - Approved - OXYMETAZOLINE

Collection

D1 : Approved

Chemical Name

OXYMETAZOLINE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
260.375 g/mol	2	3	2.6151	True

Structure

InChI

InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)

InChIKey

Links

Gene (16 / 33)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	IC50	uM	2.844	ADRA1D	-	GI(Protien) :
PubChem	Ki	uM	0.002	ADRA2A		GI(Protien) :
PubChem	IC50	uM	0.023	ADRA2A	-	GI(Protien) :
PubChem	IC50	uM	1.273	ADRA2B	-	GI(Protien) :
PubChem	Ki	uM	0.005	ADRA2C		GI(Protien) :
PubChem	IC50	uM	2.633	ADRA2C	-	GI(Protien) :
PubChem	IC50	uM	3.261	CHRM4	-	GI(Protien) :
PubChem	IC50	uM	1.332	CHRM5	-	GI(Protien) :
PubChem	Potency	uM	0.040	CYP2D6	-	GI(Protien) :
PubChem	IC50	uM	0.200	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	3.981	CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	12.589	CYP2D6	-	GI(Protien) :
PubChem		uM		CYP2D6	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem		uM		CYP3A4	-	GI(Protien) :
PubChem		uM		HTR1B		GI(Protien) :
PubChem		uM		HTR1D		GI(Protien) :
PubChem	IC50	uM	1.285	HTR2A	-	GI(Protien) :
PubChem	IC50	uM	3.056	HTR2B	-	GI(Protien) :
PubChem	IC50	uM	0.578	HTR2C	-	GI(Protien) :
PubChem		uM		HTR2C		GI(Protien) :
PubChem	IC50	uM	1.670	HTR6	-	GI(Protien) :
PubChem	Ki	uM	0.006	NISCH		GI(Protien) :
PubChem	Potency	uM	10.593	TDP1	-	GI(Protien) :
ChEMBL	Activity	-		ADRA2A	-	Target : CHEMBL1867
ChEMBL	Potency	nM	39.800	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	12589.300	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	39.810	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	3981.070	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	3981.100	CYP2D6	-	Target : CHEMBL289
ChEMBL	AC50	nM	12589.200	CYP2D6	-	Target : CHEMBL289
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	AC50	nM	15848.900	CYP3A4	-	Target : CHEMBL340

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