Tan Lab | DSigDB

Gene Set: D1 - Approved - MITOTANE

Collection

D1 : Approved

Chemical Name

MITOTANE

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
320.041 g/mol	0	0	5.929	False(3/4)

Structure

InChI

InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H/t13-/m1/s1

InChIKey

Links

Gene (20 / 35)

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Source	Type	Unit	Value	Gene	PMID	Other
PubChem	IC50	uM	7.445	ADORA3	-	GI(Protien) :
PubChem	IC50	uM	7.347	ADRA2A	-	GI(Protien) :
PubChem		uM		ARNT	-	GI(Protien) :
PubChem	Potency	uM	28.184	ATM	-	GI(Protien) :
PubChem		uM		CYP11A1		GI(Protien) :
PubChem		uM		CYP11B1		GI(Protien) :
PubChem	Potency	uM	6.001	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	7.555	ESR1	-	GI(Protien) :
PubChem	Potency	uM	7.696	ESR1	-	GI(Protien) :
PubChem	Potency	uM	8.413	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	13.804	ESR1	-	GI(Protien) :
PubChem	Potency	uM	48.972	ESR1	-	GI(Protien) :
PubChem	IC50	uM	4.832	HTR2B	-	GI(Protien) :
PubChem	IC50	uM	1.402	HTR6	-	GI(Protien) :
PubChem	Potency	uM	5.623	KCNH2		GI(Protien) :
PubChem	Potency	uM	5.623	KCNH2		GI(Protien) :
PubChem	Potency	uM	31.623	KCNH2		GI(Protien) :
PubChem	Potency	uM	31.623	KCNH2		GI(Protien) :
PubChem		uM		KCNK3	-	GI(Protien) :
PubChem	Potency	uM	66.824	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	31.623	NR1I2	-	GI(Protien) :
PubChem	Potency	uM	10.682	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	27.539	NR3C1	-	GI(Protien) :
PubChem		uM		NR3C1	-	GI(Protien) :
PubChem	Potency	uM	33.492	RORC	-	GI(Protien) :
PubChem	IC50	uM	0.819	SLC6A2	-	GI(Protien) :
PubChem	IC50	uM	1.001	SLC6A3	-	GI(Protien) :
PubChem	IC50	uM	3.015	SLC6A4	-	GI(Protien) :
PubChem		uM		TACC3	-	GI(Protien) :
PubChem	Potency	uM	68.590	TP53	-	GI(Protien) :
ChEMBL	Potency	nM	28183.800	ATM	-	Target : CHEMBL3797
ChEMBL	Potency	nM	31622.800	KCNH2	-	Target : CHEMBL240
ChEMBL	Potency	nM	5623.400	KCNH2	-	Target : CHEMBL240
ChEMBL	Potency	nM	66824.200	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	33491.500	RORC	-	Target : CHEMBL1741186

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