Tan Lab | DSigDB

Gene Set: D4 : TTD - NUTLIN-3

Collection

D4 : TTD

Chemical Name

NUTLIN-3 ( From PubChem : NUTLIN-3 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
581.49 g/mol	1	8	5.526	False(2/4)

Structure

InChI

InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28-/m1/s1

InChIKey

BDUHCSBCVGXTJM-VSGBNLITSA-N

Links

Gene (4 / 17)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			MDM2		Research target
TTD	Inhibitor			TP53		Clinical trial target
PubChem	Potency	uM	50.119	VDR	-	GI(Protien) :
PubChem	Potency	uM	12.241	YES1		GI(Protien) :
ChEMBL	Inhibition	-		MDM2	-	Target : CHEMBL5023
ChEMBL	Inhibition	-		MDM2	-	Target : CHEMBL5023
ChEMBL	Inhibition	-		MDM2	-	Target : CHEMBL5023
ChEMBL	Inhibition	-		MDM2	-	Target : CHEMBL5023
ChEMBL	Inhibition	-		MDM2	-	Target : CHEMBL5023
ChEMBL	Inhibition	-		MDM2	-	Target : CHEMBL5023
ChEMBL	Inhibition	-		MDM2	-	Target : CHEMBL1907611
ChEMBL	Inhibition	-		MDM2	-	Target : CHEMBL5023
ChEMBL	Inhibition	-		MDM2	-	Target : CHEMBL1907611
ChEMBL	Activity	-		MDM2	-	Target : CHEMBL1907611
ChEMBL	Inhibition	-		TP53	-	Target : CHEMBL1907611
ChEMBL	Inhibition	-		TP53	-	Target : CHEMBL1907611
ChEMBL	Activity	-		TP53	-	Target : CHEMBL1907611

Download gene sets

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