Tan Lab | DSigDB

Gene Set: D4 : TTD - Noradrenaline

Collection

D4 : TTD

Chemical Name

Noradrenaline ( From PubChem : NOREPINEPHRINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Approved	Not	Approved	Approved	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
169.178 g/mol	4	4	0.7902	True

Structure

InChI

InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1

InChIKey

SFLSHLFXELFNJZ-QMMMGPOBSA-N

Links

Gene (19 / 47)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Agonist			ADRB1		Successful target
PubChem	Potency	uM	3.548	BLM	-	GI(Protien) :
PubChem	Potency	uM	0.291	DRD1	-	GI(Protien) :
PubChem	Potency	uM	1.995	DRD1	-	GI(Protien) :
PubChem	Potency	uM	2.239	DRD1	-	GI(Protien) :
PubChem	Potency	uM	3.981	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	9.466	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	10.000	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	2.119	FEN1	-	GI(Protien) :
PubChem	Potency	uM	2.119	FEN1	-	GI(Protien) :
PubChem	Potency	uM	33.808	FEN1	-	GI(Protien) :
PubChem	None	uM		GAPDH	-	GI(Protien) :
PubChem	Potency	uM	3.162	MAPT	-	GI(Protien) :
PubChem	Potency	uM	3.981	MAPT	-	GI(Protien) :
PubChem	Potency	uM	5.623	MAPT	-	GI(Protien) :
PubChem	Potency	uM	6.310	MAPT	-	GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	None	uM		MAPT	-	GI(Protien) :
PubChem	Potency	uM	6.506	MBNL1	-	GI(Protien) :
PubChem	Potency	uM	1.901	POLH	-	GI(Protien) :
PubChem	Potency	uM	1.500	POLI	-	GI(Protien) :
PubChem	Potency	uM	0.708	POLK	-	GI(Protien) :
PubChem	Potency	uM	8.912	POLK	-	GI(Protien) :
PubChem	None	uM		PTGER2	-	GI(Protien) :
PubChem	Potency	uM	19.953	VDR	-	GI(Protien) :
ChEMBL	Activity	-		ADRA2A	-	Target : CHEMBL1867
ChEMBL	Activity	-		ADRA2A	-	Target : CHEMBL1867
ChEMBL	Selectivity	-		ADRB1	-	Target : CHEMBL213
ChEMBL	Selectivity	-		ADRB2	-	Target : CHEMBL210
ChEMBL	Potency	nM	794.300	APEX1	-	Target : CHEMBL5619
ChEMBL	Potency	nM	3548.100	BLM	-	Target : CHEMBL1293237
ChEMBL	Potency	nM	2238.700	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	1995.300	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	9466.200	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	10000.000	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	3981.100	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	2119.200	FEN1	-	Target : CHEMBL5027
ChEMBL	Potency	nM	7943.300	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	5623.400	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	6309.600	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	3981.100	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	3162.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	6506.400	MBNL1	-	Target : CHEMBL1293317
ChEMBL	Potency	nM	25118.900	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	2238.700	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	3548.100	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	2238.700	TDP1	-	Target : CHEMBL1075138

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