DSigDB Home
Search Gene
Collections
Browse Gene Sets
Download
Help

Gene Set: D4 : TTD - Nordihydroguaiaretic acid

Collection D4 : TTD
Chemical Name Nordihydroguaiaretic acid ( From PubChem : NORDIHYDROGUAIARETIC ACID )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
NotNotNotNotNotNotNotNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
302.365 g/mol 4 4 3.5664 True
Structure
InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3/t11-,12-/m1/s1
InChIKey HCZKYJDFEPMADG-VXGBXAGGSA-N
Links

Gene (42 / 84)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
TTDInhibitorACAT1Discontinued target
TTDInhibitorALOX5Successful target
PubChem PotencyuM10.000ALDH1A1-GI(Protien) :
PubChem PotencyuM28.184ALDH1A1-GI(Protien) :
PubChem Potency-Replicate_1uM38.895AR-GI(Protien) :
PubChem Ratio Potency (uM)uM40.417AR-GI(Protien) :
PubChem NoneuMBCL2L1-GI(Protien) :
PubChem PotencyuM12.589CYP3A4-GI(Protien) :
PubChem Potency-Replicate_1uM0.017ESR1-GI(Protien) :
PubChem IC50uM22.194ESR1-GI(Protien) :
PubChem Potency-Replicate_1uM54.941ESR1-GI(Protien) :
PubChem Ratio Potency (uM)uM54.954ESR1-GI(Protien) :
PubChem Ratio Potency (uM)uM57.090ESR1-GI(Protien) :
PubChem NoneuMESR1-GI(Protien) :
PubChem NoneuMESR2-GI(Protien) :
PubChem NoneuMGFER-GI(Protien) :
PubChem PotencyuM0.366GMNN-GI(Protien) :
PubChem NoneuMGSTO1-GI(Protien) :
PubChem PotencyuM12.589HPGD-GI(Protien) :
PubChem PotencyuM14.125HPGD-GI(Protien) :
PubChem IC50uM2.623HSP90AA1-GI(Protien) :
PubChem NoneuMHSP90AA1-GI(Protien) :
PubChem Ratio Potency (uM)uM32.726HSPB1-GI(Protien) :
PubChem NoneuMIL1B-GI(Protien) :
PubChem NoneuMPLA2G7-GI(Protien) :
PubChem NoneuMPLA2G7-GI(Protien) :
PubChem PotencyuM28.184POLH-GI(Protien) :
PubChem PotencyuM44.668POLI-GI(Protien) :
PubChem PotencyuM0.794POLK-GI(Protien) :
PubChem PotencyuM0.891POLK-GI(Protien) :
PubChem PotencyuM10.000POLK-GI(Protien) :
PubChem PotencyuM1.679TDP1-GI(Protien) :
PubChem PotencyuM2.986TDP1-GI(Protien) :
PubChem PotencyuM20.596TDP1-GI(Protien) :
PubChem PotencyuM17.783WRN-GI(Protien) :
PubChem NoneuMYWHAG-GI(Protien) :
ChEMBLPotencynM158.500ALDH1A1
-Target : CHEMBL3577
ChEMBLPotencynM2238.700ALDH1A1
-Target : CHEMBL3577
ChEMBLPotencynM28183.800ALDH1A1
-Target : CHEMBL3577
ChEMBLPotencynM10000.000ALDH1A1
-Target : CHEMBL3577
ChEMBLPotencynM1258.900ALOX15
-Target : CHEMBL2903
ChEMBLActivity-ALOX15
-Target : CHEMBL2903
ChEMBLPotencynM631.000ALOX15
-Target : CHEMBL2903
ChEMBLPotencynM3162.300ALOX15B
-Target : CHEMBL2457
ChEMBLPotencynM1584.900ALOX15B
-Target : CHEMBL2457
ChEMBLPotencynM1258.900ALOX15B
-Target : CHEMBL2457
ChEMBLActivity-AR
-Target : CHEMBL1871
ChEMBLPotencynM31622.800CBX1
-Target : CHEMBL1741193
ChEMBLPotencynM6309.600CYP2C19
-Target : CHEMBL3622
ChEMBLPotencynM1584.900CYP2C9
-Target : CHEMBL3397
ChEMBLAC50nM12589.200CYP2C9
-Target : CHEMBL3397
ChEMBLPotencynM12589.300CYP2C9
-Target : CHEMBL3397
ChEMBLPotencynM25118.900CYP2D6
-Target : CHEMBL289
ChEMBLPotencynM12589.300CYP3A4
-Target : CHEMBL340
ChEMBLPotencynM794.300EHMT2
-Target : CHEMBL6032
ChEMBLPotencynM3981.100EHMT2
-Target : CHEMBL6032
ChEMBLIC50nM22193.700ESR1
-Target : CHEMBL206
ChEMBLPotencynM751.900FEN1
-Target : CHEMBL5027
ChEMBLPotencynM11220.200GLA
-Target : CHEMBL2524
ChEMBLPotencynM14125.400HPGD
-Target : CHEMBL1293255
ChEMBLPotencynM12589.300HPGD
-Target : CHEMBL1293255
ChEMBLPotencynM3162.300HPGD
-Target : CHEMBL1293255
ChEMBLPotencynM7943.300HSD17B10
-Target : CHEMBL4159
ChEMBLPotencynM125.900HSD17B10
-Target : CHEMBL4159
ChEMBLPotencynM2511.900HSD17B10
-Target : CHEMBL4159
ChEMBLPotencynM1000.000HSD17B10
-Target : CHEMBL4159
ChEMBLIC50nM2623.200HSP90AA1
-Target : CHEMBL2095165
ChEMBLIC50nM2623.200HSP90AB1
-Target : CHEMBL2095165
ChEMBLPotencynM22387.200KDM4A
-Target : CHEMBL5896
ChEMBLPotencynM22387.200KDM4E
-Target : CHEMBL1293226
ChEMBLPotencynM14125.400KDM4E
-Target : CHEMBL1293226
ChEMBLPotencynM15848.900MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM11220.200MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM25118.900MPHOSPH8
-Target : CHEMBL1741210
ChEMBLPotencynM23778.100MPHOSPH8
-Target : CHEMBL1741210
ChEMBLPotencynM7943.300NFKB1
-Target : CHEMBL3251
ChEMBLPotencynM794.300POLB
-Target : CHEMBL2392
ChEMBLPotencynM2511.900RECQL
-Target : CHEMBL1293236
ChEMBLPotencynM2818.400RECQL
-Target : CHEMBL1293236
ChEMBLPotencynM11220.200RECQL
-Target : CHEMBL1293236
ChEMBLPotencynM44668.400RECQL
-Target : CHEMBL1293236
ChEMBLPotencynM2238.700RECQL
-Target : CHEMBL1293236
ChEMBLPotencynM5011.900THPO
-Target : CHEMBL1293256
ChEMBLPotencynM19952.600TP53
-Target : CHEMBL4096
Download gene sets gmt, text, Detailed text
Contact us
Tan Lab , Mail Stop 8117
12801 East 17th Avenue
Division of Medical Oncology , Department of Medicine
University of Colorado School of Medicine
Aurora, CO 80045, USA

* Best viewed in the latest version of Chrome (42+), Safari (8+), IE (11+) or Firefox (35+).