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Gene Set: D4 : TTD - Nifedipine

Collection D4 : TTD
Chemical Name Nifedipine ( From PubChem : NIFEDIPINE )
FDA NPC WHO Indian Australia China Traditional
Herbal		 Clinical
Trail
ApprovedNotApprovedApprovedApprovedApprovedNotNot
Molecular
Weight		 Hydrogen Bond
Donor Count		 Hydrogen Bond
Acceptor Count		 cLogP Lipinski Rule
346.335 g/mol 1 5 3.0276 True
Structure
InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
InChIKey HYIMSNHJOBLJNT-UHFFFAOYSA-N
Links

Gene (46 / 162)


⊖ Less
Source Type Unit Value Gene PMID Assay Other
TTDDrug(s)CACNA2D1Successful target
TTDBlockerCACNA2D1Successful target
TTDDrug(s)CACNG1Successful target
TTDBlockerCACNG1Successful target
PubChem IC50uM7.133ABHD5-GI(Protien) :
PubChem IC50uM9.619ABHD5-GI(Protien) :
PubChem NoneuMABHD5-GI(Protien) :
PubChem NoneuMABHD5-GI(Protien) :
PubChem AhR Potency (uM)uM3.067AHR-GI(Protien) :
PubChem AhR Potency (uM)uM9.808AHR-GI(Protien) :
PubChem NoneuMAHR-GI(Protien) :
PubChem PotencyuM8.912ALDH1A1-GI(Protien) :
PubChem PotencyuM15.849ALDH1A1-GI(Protien) :
PubChem Potency-Replicate_1uM54.538AR-GI(Protien) :
PubChem Potency-Replicate_1uM55.028AR-GI(Protien) :
PubChem PotencyuM10.322ATAD5-GI(Protien) :
PubChem PotencyuM18.349ATAD5-GI(Protien) :
PubChem PotencyuM11.220ATXN2-GI(Protien) :
PubChem PotencyuM28.184ATXN2-GI(Protien) :
PubChem PotencyuM39.811BAZ2B-GI(Protien) :
PubChem IC50uM1.120CACNA1B-GI(Protien) :
PubChem IC50uM10.100CACNA1B-GI(Protien) :
PubChem PotencyuM35.481CBX1-GI(Protien) :
PubChem Potency-Replicate_1uM68.659CYP19A1-GI(Protien) :
PubChem NoneuMCYP19A1-GI(Protien) :
PubChem NoneuMCYP1A2-GI(Protien) :
PubChem NoneuMCYP1A2-GI(Protien) :
PubChem PotencyuM15.849CYP2C19-GI(Protien) :
PubChem PotencyuM10.000CYP3A4-GI(Protien) :
PubChem PotencyuM12.589CYP3A4-GI(Protien) :
PubChem NoneuMCYP3A4-GI(Protien) :
PubChem PotencyuM2.593DRD1-GI(Protien) :
PubChem NoneuMDRD3-GI(Protien) :
PubChem PotencyuM2.994EHMT2-GI(Protien) :
PubChem PotencyuM4.467EHMT2-GI(Protien) :
PubChem PotencyuM11.220EHMT2-GI(Protien) :
PubChem PotencyuM14.125EHMT2-GI(Protien) :
PubChem NoneuMGAPDH-GI(Protien) :
PubChem PotencyuM12.589GMNN-GI(Protien) :
PubChem PotencyuM0.501HIF1A-GI(Protien) :
PubChem PotencyuM1.000HIF1A-GI(Protien) :
PubChem PotencyuM11.220HPGD-GI(Protien) :
PubChem NoneuMKCNJ1-GI(Protien) :
PubChem PotencyuM25.119MAPK1-GI(Protien) :
PubChem PotencyuM3.548MAPT-GI(Protien) :
PubChem PotencyuM3.548MAPT-GI(Protien) :
PubChem PotencyuM3.981MAPT-GI(Protien) :
PubChem PotencyuM4.467MAPT-GI(Protien) :
PubChem PotencyuM7.943MAPT-GI(Protien) :
PubChem PotencyuM8.912MAPT-GI(Protien) :
PubChem PotencyuM12.589MAPT-GI(Protien) :
PubChem PotencyuM14.125MAPT-GI(Protien) :
PubChem PotencyuM15.849MAPT-GI(Protien) :
PubChem PotencyuM19.953MAPT-GI(Protien) :
PubChem PotencyuM19.953MAPT-GI(Protien) :
PubChem PotencyuM22.387MAPT-GI(Protien) :
PubChem NoneuMMDM2-GI(Protien) :
PubChem NoneuMMDM2-GI(Protien) :
PubChem NoneuMMDM4-GI(Protien) :
PubChem NoneuMMDM4-GI(Protien) :
PubChem PotencyuM39.811MPHOSPH8-GI(Protien) :
PubChem IC50uMMPI-GI(Protien) :
PubChem IC50uMMPI-GI(Protien) :
PubChem PotencyuM12.995NFE2L2-GI(Protien) :
PubChem PotencyuM11.220NFKB1-GI(Protien) :
PubChem NoneuMNR1H4-GI(Protien) :
PubChem NoneuMNR1I2-GI(Protien) :
PubChem Potency-Replicate_1uM10.682NR3C1-GI(Protien) :
PubChem Potency-Replicate_1uM27.579NR3C1-GI(Protien) :
PubChem PotencyuM31.623NR3C1-GI(Protien) :
PubChem NoneuMNR3C1-GI(Protien) :
PubChem PotencyuM23.109PARK2-GI(Protien) :
PubChem IC50uM9.619PLIN1-GI(Protien) :
PubChem NoneuMPLIN1-GI(Protien) :
PubChem IC50uM7.133PLIN5-GI(Protien) :
PubChem NoneuMPLIN5-GI(Protien) :
PubChem PotencyuM2.119RGS4-GI(Protien) :
PubChem NoneuMRGS4-GI(Protien) :
PubChem NoneuMSLC12A5-GI(Protien) :
PubChem PotencyuM2.593TDP1-GI(Protien) :
PubChem PotencyuM5.173TDP1-GI(Protien) :
PubChem PotencyuM7.080TDP1-GI(Protien) :
PubChem PotencyuM9.200TDP1-GI(Protien) :
PubChem PotencyuM9.441TDP1-GI(Protien) :
PubChem PotencyuM10.000TDP1-GI(Protien) :
PubChem PotencyuM11.582TDP1-GI(Protien) :
PubChem PotencyuM11.886TDP1-GI(Protien) :
PubChem PotencyuM12.995TDP1-GI(Protien) :
PubChem PotencyuM12.995TDP1-GI(Protien) :
PubChem PotencyuM23.715TDP1-GI(Protien) :
PubChem PotencyuM3.162VDR-GI(Protien) :
PubChem PotencyuM3.162VDR-GI(Protien) :
PubChem PotencyuM3.162VDR-GI(Protien) :
PubChem PotencyuM3.548VDR-GI(Protien) :
PubChem PotencyuM3.548VDR-GI(Protien) :
PubChem PotencyuM3.548VDR-GI(Protien) :
PubChem PotencyuM3.981VDR-GI(Protien) :
PubChem PotencyuM5.623VDR-GI(Protien) :
PubChem PotencyuM6.310VDR-GI(Protien) :
PubChem PotencyuM6.310VDR-GI(Protien) :
PubChem PotencyuM7.080VDR-GI(Protien) :
PubChem PotencyuM7.080VDR-GI(Protien) :
PubChem PotencyuM7.080VDR-GI(Protien) :
PubChem PotencyuM8.912VDR-GI(Protien) :
PubChem PotencyuM8.912VDR-GI(Protien) :
PubChem PotencyuM10.000VDR-GI(Protien) :
PubChem PotencyuM11.220VDR-GI(Protien) :
PubChem PotencyuM25.119VDR-GI(Protien) :
ChEMBLPotencynM15848.900ALDH1A1
-Target : CHEMBL3577
ChEMBLPotencynM8912.500ALDH1A1
-Target : CHEMBL3577
ChEMBLIC50nM10100.000APBA1
-Target : CHEMBL2097170
ChEMBLIC50nM1120.000APBA1
-Target : CHEMBL2097170
ChEMBLPotencynM18348.900ATAD5
-Target : CHEMBL1741209
ChEMBLPotencynM10322.500ATAD5
-Target : CHEMBL1741209
ChEMBLPotencynM39810.700BAZ2B
-Target : CHEMBL1741220
ChEMBLIC50nM10100.000CACNA1B
-Target : CHEMBL2097170
ChEMBLIC50nM1120.000CACNA1B
-Target : CHEMBL2097170
ChEMBLPotencynM35481.300CBX1
-Target : CHEMBL1741193
ChEMBLInhibition-CYP1A2
-Target : CHEMBL3356
ChEMBLAC50nM50.120CYP1A2
-Target : CHEMBL3356
ChEMBLAC50nM39.810CYP1A2
-Target : CHEMBL3356
ChEMBLInhibition-CYP2C19
-Target : CHEMBL3622
ChEMBLPotencynM15848.900CYP2C19
-Target : CHEMBL3622
ChEMBLInhibition-CYP2C9
-Target : CHEMBL3397
ChEMBLInhibition-CYP2D6
-Target : CHEMBL289
ChEMBLInhibition-CYP3A4
-Target : CHEMBL340
ChEMBLInhibition-CYP3A4
-Target : CHEMBL340
ChEMBLPotencynM12589.300CYP3A4
-Target : CHEMBL340
ChEMBLAC50nM12589.200CYP3A4
-Target : CHEMBL340
ChEMBLPotencynM10000.000CYP3A4
-Target : CHEMBL340
ChEMBLAC50nM10000.000CYP3A4
-Target : CHEMBL340
ChEMBLPotencynM2592.800DRD1
-Target : CHEMBL2056
ChEMBLPotencynM11220.200EHMT2
-Target : CHEMBL6032
ChEMBLPotencynM2993.500EHMT2
-Target : CHEMBL6032
ChEMBLPotencynM4466.800EHMT2
-Target : CHEMBL6032
ChEMBLPotencynM14125.400EHMT2
-Target : CHEMBL6032
ChEMBLPotencynM12589.300GMNN
-Target : CHEMBL1293278
ChEMBLPotencynM1000.000HIF1A
-Target : CHEMBL4261
ChEMBLPotencynM501.200HIF1A
-Target : CHEMBL4261
ChEMBLPotencynM11220.200HPGD
-Target : CHEMBL1293255
ChEMBLPotencynM7943.300HSD17B10
-Target : CHEMBL4159
ChEMBLPotencynM10000.000HSD17B10
-Target : CHEMBL4159
ChEMBLPotencynM25118.900KDM4E
-Target : CHEMBL1293226
ChEMBLPotencynM22387.200KDM4E
-Target : CHEMBL1293226
ChEMBLPotencynM28183.800KDM4E
-Target : CHEMBL1293226
ChEMBLPotencynM14125.400KDM4E
-Target : CHEMBL1293226
ChEMBLPotencynM25118.900MAPK1
-Target : CHEMBL4040
ChEMBLPotencynM12589.300MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM3981.100MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM19952.600MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM14125.400MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM4466.800MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM19952.600MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM15848.900MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM7943.300MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM3548.100MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM3548.100MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM8912.500MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM22387.200MAPT
-Target : CHEMBL1293224
ChEMBLPotencynM39810.700MPHOSPH8
-Target : CHEMBL1741210
ChEMBLPotencynM12995.300NFE2L2
-Target : CHEMBL1075094
ChEMBLPotencynM11220.200NFKB1
-Target : CHEMBL3251
Download gene sets gmt, text, Detailed text
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Aurora, CO 80045, USA

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