Tan Lab | DSigDB

Gene Set: D4 : TTD - Mitotane

Collection

D4 : TTD

Chemical Name

Mitotane ( From PubChem : MITOTANE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
320.041 g/mol	0	0	5.929	False(3/4)

Structure

InChI

InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H/t13-/m1/s1

InChIKey

Links

Gene (9 / 21)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Drug(s)			ESR1		Successful target
PubChem	None	uM		ARNT	-	GI(Protien) :
PubChem	Potency	uM	28.184	ATM	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.001	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	7.555	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	7.696	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.413	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	13.804	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	48.972	ESR1	-	GI(Protien) :
PubChem	Potency	uM	5.623	KCNH2		GI(Protien) :
PubChem	Potency	uM	5.623	KCNH2		GI(Protien) :
PubChem	Potency	uM	31.623	KCNH2		GI(Protien) :
PubChem	Potency	uM	31.623	KCNH2		GI(Protien) :
PubChem	None	uM		KCNK3	-	GI(Protien) :
PubChem	Potency	uM	66.824	NFE2L2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	31.623	NR1I2	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.682	NR3C1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	27.539	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		TACC3	-	GI(Protien) :
ChEMBL	Potency	nM	28183.800	ATM	-	Target : CHEMBL3797

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