Tan Lab | DSigDB

Gene Set: D4 : TTD - Mifepristone

Collection

D4 : TTD

Chemical Name

Mifepristone ( From PubChem : MIFEPRISTONE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Approved	Approved	Not	Approved	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
429.594 g/mol	1	3	5.4065	False(3/4)

Structure

InChI

InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1

InChIKey

VKHAHZOOUSRJNA-GCNJZUOMSA-N

Links

Gene (22 / 58)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Antagonist			PGR		Successful target
TTD	Drug(s)			PGR		Successful target
PubChem	None	uM		ABCB1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.002	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.015	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.190	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.268	AR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	0.347	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	3.758	AR	-	GI(Protien) :
PubChem	AR Potency (uM)	uM	7.696	AR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	8.635	AR	-	GI(Protien) :
PubChem	Potency	uM	12.589	BAZ2B	-	GI(Protien) :
PubChem	Potency	uM	25.119	CBX1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	11.883	CYP19A1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	30.638	CYP19A1	-	GI(Protien) :
PubChem	Potency	uM	2.311	DRD1	-	GI(Protien) :
PubChem	Potency	uM	9.466	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	12.589	EHMT2	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	3.510	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	6.007	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	10.152	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	10.962	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	16.785	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	17.442	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	68.590	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	68.590	ESR1	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		MLLT3	-	GI(Protien) :
PubChem	Potency	uM	11.917	MPHOSPH8	-	GI(Protien) :
PubChem	Potency	uM	11.668	MTOR	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	7.696	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	21.690	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	23.109	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	23.109	NFE2L2	-	GI(Protien) :
PubChem	Potency	uM	12.589	NPSR1	-	GI(Protien) :
PubChem	None	uM		NR1H4	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	0.008	NR3C1	-	GI(Protien) :
PubChem	Potency	uM	0.025	NR3C1	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		PPARD	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		PREPL	-	GI(Protien) :
PubChem	None	uM		PREPL	-	GI(Protien) :
PubChem	Potency	uM	23.109	TDP1	-	GI(Protien) :
PubChem	Potency	uM	23.109	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	12589.300	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	25118.900	CBX1	-	Target : CHEMBL1741193
ChEMBL	Potency	nM	2310.800	DRD1	-	Target : CHEMBL2056
ChEMBL	Potency	nM	12589.300	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	9466.200	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	2818.400	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	15848.900	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	11917.300	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	15848.900	MPHOSPH8	-	Target : CHEMBL1741210
ChEMBL	Potency	nM	11668.100	MTOR	-	Target : CHEMBL2842
ChEMBL	Potency	nM	23109.300	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	23109.300	NFE2L2	-	Target : CHEMBL1075094
ChEMBL	Potency	nM	12589.300	NPSR1	-	Target : CHEMBL5162

Download gene sets

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