Tan Lab | DSigDB

Gene Set: D4 : TTD - Luteolin

Collection

D4 : TTD

Chemical Name

Luteolin ( From PubChem : LUTEOLIN )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Approved	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
286.236 g/mol	4	6	2.2824	True

Structure

InChI

InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

InChIKey

IQPNAANSBPBGFQ-UHFFFAOYSA-N

Links

Gene (44 / 84)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			TOP1		Successful target
PubChem	Potency	uM	8.912	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	19.953	ALDH1A1	-	GI(Protien) :
PubChem	Potency	uM	1.585	ALOX15	-	GI(Protien) :
PubChem	Potency	uM	2.512	ALOX15	-	GI(Protien) :
PubChem	None	uM		ALPI	-	GI(Protien) :
PubChem	Potency	uM	79.433	BAZ2B	-	GI(Protien) :
PubChem	Potency	uM	3.827	BLM	-	GI(Protien) :
PubChem	Potency	uM	35.481	BLM	-	GI(Protien) :
PubChem	None	uM		CBR3	-	GI(Protien) :
PubChem	AC50_uM	uM	29.270	CFTR	-	GI(Protien) :
PubChem	None	uM		CFTR	-	GI(Protien) :
PubChem	None	uM		CLK3	-	GI(Protien) :
PubChem	None	uM		CSNK1G2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	None	uM		CYP1A2	-	GI(Protien) :
PubChem	Potency	uM	15.849	CYP3A4	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	None	uM		DRD3	-	GI(Protien) :
PubChem	Potency	uM	10.000	EHMT2	-	GI(Protien) :
PubChem	Potency	uM	11.220	FEN1	-	GI(Protien) :
PubChem	Potency	uM	25.119	GAA	-	GI(Protien) :
PubChem	EC50_uM	uM	3.812	GSK3B	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	None	uM		GSTO1	-	GI(Protien) :
PubChem	Potency	uM	11.220	HPGD	-	GI(Protien) :
PubChem	None	uM		HPGD	-	GI(Protien) :
PubChem	Potency	uM	12.589	MAPT	-	GI(Protien) :
PubChem	None	uM		MCL1	-	GI(Protien) :
PubChem	None	uM		PAFAH1B2	-	GI(Protien) :
PubChem	None	uM		PAFAH1B3	-	GI(Protien) :
PubChem	None	uM		PIM2	-	GI(Protien) :
PubChem	Potency	uM	7.080	POLB	-	GI(Protien) :
PubChem	Potency	uM	3.162	POLH	-	GI(Protien) :
PubChem	Potency	uM	3.981	POLI	-	GI(Protien) :
PubChem	Potency	uM	0.267	POLK	-	GI(Protien) :
PubChem	Potency	uM	0.891	POLK	-	GI(Protien) :
PubChem	Potency	uM	1.500	POLK	-	GI(Protien) :
PubChem	Potency	uM	6.310	POLK	-	GI(Protien) :
PubChem	Potency	uM	14.125	POLK	-	GI(Protien) :
PubChem	IC50	uM	1.059	PSIP1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	None	uM		PSIP1	-	GI(Protien) :
PubChem	Potency	uM	8.912	SMN2	-	GI(Protien) :
PubChem	None	uM		STK16	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	None	uM		TRA	-	GI(Protien) :
PubChem	Potency	uM	3.040	WRN	-	GI(Protien) :
PubChem	Potency	uM	10.000	WRN	-	GI(Protien) :
ChEMBL	Potency	nM	8912.500	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	19952.600	ALDH1A1	-	Target : CHEMBL3577
ChEMBL	Potency	nM	2511.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	1584.900	ALOX15	-	Target : CHEMBL2903
ChEMBL	Potency	nM	15848.900	ALOX15B	-	Target : CHEMBL2457
ChEMBL	Inhibition	-		APP	-	Target : CHEMBL2487
ChEMBL	Potency	nM	79432.800	BAZ2B	-	Target : CHEMBL1741220
ChEMBL	Potency	nM	35481.300	BLM	-	Target : CHEMBL1293237
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	Inhibition	-		CYBB	-	Target : CHEMBL1287627
ChEMBL	AC50	nM	251.190	CYP1A2	-	Target : CHEMBL3356
ChEMBL	Potency	nM	15848.900	CYP3A4	-	Target : CHEMBL340
ChEMBL	Potency	nM	10000.000	EHMT2	-	Target : CHEMBL6032
ChEMBL	Potency	nM	25118.900	GAA	-	Target : CHEMBL2608
ChEMBL	Activity	-		GPR35	-	Target : CHEMBL1293267
ChEMBL	Activity	-		GPR35	-	Target : CHEMBL1293267
ChEMBL	Potency	nM	11220.200	HPGD	-	Target : CHEMBL1293255
ChEMBL	Potency	nM	15848.900	HSD17B10	-	Target : CHEMBL4159
ChEMBL	Potency	nM	44668.400	KDM4A	-	Target : CHEMBL5896
ChEMBL	Potency	nM	8912.500	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	12589.300	KDM4E	-	Target : CHEMBL1293226
ChEMBL	Potency	nM	12589.300	MAPT	-	Target : CHEMBL1293224
ChEMBL	Potency	nM	7079.500	POLB	-	Target : CHEMBL2392
ChEMBL	Potency	nM	7943.300	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	6309.600	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	12589.300	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	8912.500	RECQL	-	Target : CHEMBL1293236
ChEMBL	Potency	nM	8912.500	SMN1; SMN2	-	Target : CHEMBL1293232
ChEMBL	Activity	-		TNFRSF10B	-	Target : CHEMBL1075153
ChEMBL	ID50	-		TYR	-	Target : CHEMBL1973

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