Tan Lab | DSigDB

Gene Set: D4 : TTD - Liothyronine

Collection

D4 : TTD

Chemical Name

Liothyronine ( From PubChem : LIOTHYRONINE )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Approved	Not	Not	Not	Approved	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
650.974 g/mol	3	5	4.653	False(3/4)

Structure

InChI

InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

InChIKey

Links

Gene (21 / 34)

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Source	Type	Unit	Value	Gene	PMID	Other
TTD	Antagonist			THRA		Successful target
TTD	Drug(s)			THRA		Successful target
PubChem	AhR Potency (uM)	uM	3.349	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	5.308	AHR	-	GI(Protien) :
PubChem	AhR Potency (uM)	uM	10.468	AHR	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	9.511	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	9.511	ESR1	-	GI(Protien) :
PubChem	ER Potency (uM)	uM	22.384	ESR1	-	GI(Protien) :
PubChem	Ratio Potency (uM)	uM	23.915	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	23.915	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	26.603	ESR1	-	GI(Protien) :
PubChem	Potency-Replicate_1	uM	37.141	ESR1	-	GI(Protien) :
PubChem	None	uM		ESRRG	-	GI(Protien) :
PubChem	None	uM		HNF4A	-	GI(Protien) :
PubChem	None	uM		NPY1R	-	GI(Protien) :
PubChem	None	uM		NR3C1	-	GI(Protien) :
PubChem	None	uM		NR4A2	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A1	-	GI(Protien) :
PubChem	None	uM		NR5A2	-	GI(Protien) :
PubChem	None	uM		PPARG	-	GI(Protien) :
PubChem	None	uM		RARA	-	GI(Protien) :
PubChem	None	uM		RARA	-	GI(Protien) :
PubChem	None	uM		RARB	-	GI(Protien) :
PubChem	None	uM		RARB	-	GI(Protien) :
PubChem	None	uM		RORA	-	GI(Protien) :
PubChem	None	uM		RORC	-	GI(Protien) :
PubChem	None	uM		THRB	-	GI(Protien) :
ChEMBL	Inhibition	-		CYP1A2	-	Target : CHEMBL3356
ChEMBL	Inhibition	-		CYP2C19	-	Target : CHEMBL3622
ChEMBL	Inhibition	-		CYP2C9	-	Target : CHEMBL3397
ChEMBL	Inhibition	-		CYP2D6	-	Target : CHEMBL289
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340
ChEMBL	Inhibition	-		CYP3A4	-	Target : CHEMBL340

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