Tan Lab | DSigDB

Gene Set: D4 : TTD - KN-62

Collection

D4 : TTD

Chemical Name

KN-62 ( From PubChem : KN-62 )

FDA	NPC	WHO	Indian	Australia	China	Traditional Herbal	Clinical Trail
Not	Not	Not	Not	Not	Not	Not	Not

Molecular Weight	Hydrogen Bond Donor Count	Hydrogen Bond Acceptor Count	cLogP	Lipinski Rule
721.844 g/mol	0	11	7.2958	False(1/4)

Structure

InChI

InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27,35H,21-25H2,1H3/t35-/m0/s1

InChIKey

RJVLFQBBRSMWHX-DHUJRADRSA-N

Links

Gene (18 / 21)

⊖ Less

Source	Type	Unit	Value	Gene	PMID	Other
TTD	Inhibitor			AKT1		Clinical trial target
TTD	Inhibitor			AKT2		Clinical trial target
TTD	Inhibitor			AKT3		Clinical trial target
TTD	Inhibitor			CHEK1		Clinical trial target
TTD	Inhibitor			LCK		Successful target
TTD	Inhibitor			MAPK1		Research target
TTD	Inhibitor			MAPK11		Research target
TTD	Inhibitor			MAPK12		Clinical trial target
TTD	Inhibitor			MAPK14		Clinical trial target
TTD	Inhibitor			MAPK8		Clinical trial target
TTD	Inhibitor			P2RX7		Discontinued target
TTD	Inhibitor			PRKCA		Clinical trial target
TTD	Inhibitor			ROCK1		Clinical trial target
TTD	Inhibitor			RPS6KB1		Discontinued target
TTD	Inhibitor			SGK1		Research target
PubChem	Potency	uM	9.200	ATAD5	-	GI(Protien) :
PubChem	None	uM		PPP1CA	-	GI(Protien) :
PubChem	None	uM		PPP1CA	-	GI(Protien) :
PubChem	Potency	uM	2.909	TDP1	-	GI(Protien) :
PubChem	Potency	uM	8.200	TDP1	-	GI(Protien) :
ChEMBL	Potency	nM	9200.000	ATAD5	-	Target : CHEMBL1741209

Download gene sets

gmt, text, Detailed text